FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147357420> ?p ?o ?g. }

• W2147357420 endingPage "1349" @default.
• W2147357420 startingPage "1337" @default.
• W2147357420 abstract "Necrotic bone exposure in the oral cavity has recently been reported in patients treated with nitrogen-containing bisphosphonates as part of their therapeutic regimen for multiple myeloma or metastatic cancers to bone. It has been postulated that systemic conditions associated with cancer patients combined with tooth extraction may increase the risk of osteonecrosis of the jaw (ONJ). The objective of this study was to establish an animal model of bisphosphonate-related ONJ by testing the combination of these risk factors. The generation of ONJ lesions in rats resembling human disease was achieved under the confluence of intravenous injection of zoledronate (ZOL; 35 µg/kg every 2 weeks), maxillary molar extraction, and vitamin D deficiency [VitD(−)]. The prevalence of ONJ in the VitD(−)/ZOL group was 66.7%, which was significantly higher (p < .05, Fisher exact test) than the control (0%), VitD(−) (0%), and ZOL alone (14.3%) groups. Similar to human patients, rat ONJ lesions prolonged the oral exposure of necrotic bone sequestra and were uniquely associated with pseudoepitheliomatous hyperplasia. The number of terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate–biotin nick-end label–positive (TUNEL+) osteoclasts significantly increased on the surface of post–tooth extraction alveolar bone of the VitD(−)/ZOL group, where sustained inflammation was depicted by [18F]fluorodeoxyglucose micro-positron emission tomography (µPET). ONJ lesions were found to be associated with dense accumulation of mixed inflammatory/immune cells. These cells, composed of neutrophils and lymphocytes, appeared to juxtapose apoptotic osteoclasts. It is suggested that the pathophysiologic mechanism(s) underpinning ONJ may involve the interaction between bisphosphonates and compromised vitamin D functions in the realm of skeletal homeostasis and innate immunity. © 2010 American Society for Bone and Mineral Research" @default.
• W2147357420 created "2016-06-24" @default.
• W2147357420 creator A5003416716 @default.
• W2147357420 creator A5005022757 @default.
• W2147357420 creator A5018617065 @default.
• W2147357420 creator A5031985428 @default.
• W2147357420 creator A5037040516 @default.
• W2147357420 creator A5040780486 @default.
• W2147357420 creator A5059173570 @default.
• W2147357420 creator A5086824064 @default.
• W2147357420 creator A5090785184 @default.
• W2147357420 date "2010-01-14" @default.
• W2147357420 modified "2023-10-10" @default.
• W2147357420 title "Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats" @default.
• W2147357420 cites W1531471821 @default.
• W2147357420 cites W1545187328 @default.
• W2147357420 cites W1756758942 @default.
• W2147357420 cites W1916702328 @default.
• W2147357420 cites W1948868238 @default.
• W2147357420 cites W1967341644 @default.
• W2147357420 cites W1972181361 @default.
• W2147357420 cites W1980180313 @default.
• W2147357420 cites W1988968838 @default.
• W2147357420 cites W1989961008 @default.
• W2147357420 cites W1990119475 @default.
• W2147357420 cites W1991009866 @default.
• W2147357420 cites W1995435702 @default.
• W2147357420 cites W1997579601 @default.
• W2147357420 cites W1998473468 @default.
• W2147357420 cites W2003692790 @default.
• W2147357420 cites W2020145536 @default.
• W2147357420 cites W2023471926 @default.
• W2147357420 cites W2029620076 @default.
• W2147357420 cites W2031650256 @default.
• W2147357420 cites W2040436190 @default.
• W2147357420 cites W2044675846 @default.
• W2147357420 cites W2053067885 @default.
• W2147357420 cites W2056910995 @default.
• W2147357420 cites W2057133975 @default.
• W2147357420 cites W2058450560 @default.
• W2147357420 cites W2059383171 @default.
• W2147357420 cites W2065266997 @default.
• W2147357420 cites W2067614596 @default.
• W2147357420 cites W2068602966 @default.
• W2147357420 cites W2072396430 @default.
• W2147357420 cites W2080076458 @default.
• W2147357420 cites W2087575862 @default.
• W2147357420 cites W2093282432 @default.
• W2147357420 cites W2094398444 @default.
• W2147357420 cites W2094899368 @default.
• W2147357420 cites W2102473755 @default.
• W2147357420 cites W2107208293 @default.
• W2147357420 cites W2111405627 @default.
• W2147357420 cites W2121798607 @default.
• W2147357420 cites W2122473686 @default.
• W2147357420 cites W2124580054 @default.
• W2147357420 cites W2133506402 @default.
• W2147357420 cites W2137302084 @default.
• W2147357420 cites W2138220544 @default.
• W2147357420 cites W2144247138 @default.
• W2147357420 cites W2150904792 @default.
• W2147357420 cites W2150929098 @default.
• W2147357420 cites W2152741211 @default.
• W2147357420 cites W2154102227 @default.
• W2147357420 cites W2163852287 @default.
• W2147357420 cites W2167130416 @default.
• W2147357420 cites W2169512870 @default.
• W2147357420 cites W282464114 @default.
• W2147357420 cites W4230073941 @default.
• W2147357420 cites W4239901602 @default.
• W2147357420 cites W4285719527 @default.
• W2147357420 cites W4362561698 @default.
• W2147357420 cites W4376595748 @default.
• W2147357420 doi "https://doi.org/10.1002/jbmr.23" @default.
• W2147357420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3153137" @default.
• W2147357420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20200938" @default.
• W2147357420 hasPublicationYear "2010" @default.
• W2147357420 type Work @default.
• W2147357420 sameAs 2147357420 @default.
• W2147357420 citedByCount "148" @default.
• W2147357420 countsByYear W21473574202012 @default.
• W2147357420 countsByYear W21473574202013 @default.
• W2147357420 countsByYear W21473574202014 @default.
• W2147357420 countsByYear W21473574202015 @default.
• W2147357420 countsByYear W21473574202016 @default.
• W2147357420 countsByYear W21473574202017 @default.
• W2147357420 countsByYear W21473574202018 @default.
• W2147357420 countsByYear W21473574202019 @default.
• W2147357420 countsByYear W21473574202020 @default.
• W2147357420 countsByYear W21473574202021 @default.
• W2147357420 countsByYear W21473574202022 @default.
• W2147357420 countsByYear W21473574202023 @default.
• W2147357420 crossrefType "journal-article" @default.
• W2147357420 hasAuthorship W2147357420A5003416716 @default.
• W2147357420 hasAuthorship W2147357420A5005022757 @default.
• W2147357420 hasAuthorship W2147357420A5018617065 @default.
• W2147357420 hasAuthorship W2147357420A5031985428 @default.
• W2147357420 hasAuthorship W2147357420A5037040516 @default.

• next