Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147360897> ?p ?o ?g. }
- W2147360897 endingPage "61" @default.
- W2147360897 startingPage "53" @default.
- W2147360897 abstract "thioredoxin interacting protein (Txnip). In the present study, the relationship between diabetic nephropathy and Txnip was investigated using streptozotocin (STZ)-induced diabetic mice. Eight-week-old male C57BL/6 mice were treated with either STZ or citrate vehicle. After 24 weeks of treatment, diabetic nephropathy and oxidative stress were assessed by biochemical analyses of urine and histological analyses of the kidneys. In addition, the expression of Type IV collagen α1 chain (Col4A1), Transforming growth factor-β (TGF-β), and Txnip were evaluated by real-time polymerase chain reaction. Albuminuria, renal hypertrophy, and expansion of the mesangial area, which are the hallmarks of diabetic nephropathy, were confirmed in the diabetic mice. The mRNA expression of COL4A1 and TGF-β was dramatically increased in diabetic mice in comparison with the control mice. Moreover, associated with the increased renal expression of Txnip, diabetic conditions increased oxidative stress as determined by urinary excretion of 8-hydroxy-2'-deoxyguanosine and acrolein adduct, which are oxidative stress markers. Moreover, Txnip may be a therapeutic target in diabetic nephropathy." @default.
- W2147360897 created "2016-06-24" @default.
- W2147360897 creator A5081126904 @default.
- W2147360897 creator A5089711554 @default.
- W2147360897 date "2007-01-01" @default.
- W2147360897 modified "2023-09-26" @default.
- W2147360897 title "A Possible Role of Thioredoxin Interacting Protein in the Pathogenesis of Streptozotocin-induced Diabetic Nephropathy" @default.
- W2147360897 cites W1529592271 @default.
- W2147360897 cites W1551392207 @default.
- W2147360897 cites W1973515129 @default.
- W2147360897 cites W1982145118 @default.
- W2147360897 cites W1992808358 @default.
- W2147360897 cites W2001705690 @default.
- W2147360897 cites W2003847438 @default.
- W2147360897 cites W2044437167 @default.
- W2147360897 cites W2063016600 @default.
- W2147360897 cites W2070414513 @default.
- W2147360897 cites W2091321868 @default.
- W2147360897 cites W2105662115 @default.
- W2147360897 cites W2109168147 @default.
- W2147360897 cites W2120833123 @default.
- W2147360897 cites W2132403739 @default.
- W2147360897 cites W2138585662 @default.
- W2147360897 cites W2141802124 @default.
- W2147360897 cites W2145356697 @default.
- W2147360897 cites W2153876718 @default.
- W2147360897 cites W2155009865 @default.
- W2147360897 cites W2165325650 @default.
- W2147360897 cites W2169878907 @default.
- W2147360897 cites W2170492101 @default.
- W2147360897 cites W2184009989 @default.
- W2147360897 cites W2340025308 @default.
- W2147360897 cites W2418572439 @default.
- W2147360897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17582205" @default.
- W2147360897 hasPublicationYear "2007" @default.
- W2147360897 type Work @default.
- W2147360897 sameAs 2147360897 @default.
- W2147360897 citedByCount "7" @default.
- W2147360897 countsByYear W21473608972012 @default.
- W2147360897 countsByYear W21473608972015 @default.
- W2147360897 countsByYear W21473608972016 @default.
- W2147360897 countsByYear W21473608972017 @default.
- W2147360897 countsByYear W21473608972018 @default.
- W2147360897 crossrefType "journal-article" @default.
- W2147360897 hasAuthorship W2147360897A5081126904 @default.
- W2147360897 hasAuthorship W2147360897A5089711554 @default.
- W2147360897 hasConcept C126322002 @default.
- W2147360897 hasConcept C134018914 @default.
- W2147360897 hasConcept C2776151105 @default.
- W2147360897 hasConcept C2776174234 @default.
- W2147360897 hasConcept C2779076967 @default.
- W2147360897 hasConcept C2779280383 @default.
- W2147360897 hasConcept C2779922275 @default.
- W2147360897 hasConcept C2780942790 @default.
- W2147360897 hasConcept C2781184683 @default.
- W2147360897 hasConcept C2909763481 @default.
- W2147360897 hasConcept C3623737 @default.
- W2147360897 hasConcept C555293320 @default.
- W2147360897 hasConcept C71924100 @default.
- W2147360897 hasConceptScore W2147360897C126322002 @default.
- W2147360897 hasConceptScore W2147360897C134018914 @default.
- W2147360897 hasConceptScore W2147360897C2776151105 @default.
- W2147360897 hasConceptScore W2147360897C2776174234 @default.
- W2147360897 hasConceptScore W2147360897C2779076967 @default.
- W2147360897 hasConceptScore W2147360897C2779280383 @default.
- W2147360897 hasConceptScore W2147360897C2779922275 @default.
- W2147360897 hasConceptScore W2147360897C2780942790 @default.
- W2147360897 hasConceptScore W2147360897C2781184683 @default.
- W2147360897 hasConceptScore W2147360897C2909763481 @default.
- W2147360897 hasConceptScore W2147360897C3623737 @default.
- W2147360897 hasConceptScore W2147360897C555293320 @default.
- W2147360897 hasConceptScore W2147360897C71924100 @default.
- W2147360897 hasIssue "2" @default.
- W2147360897 hasLocation W21473608971 @default.
- W2147360897 hasLocation W21473608972 @default.
- W2147360897 hasOpenAccess W2147360897 @default.
- W2147360897 hasPrimaryLocation W21473608971 @default.
- W2147360897 hasRelatedWork W129485647 @default.
- W2147360897 hasRelatedWork W1413571910 @default.
- W2147360897 hasRelatedWork W1505969961 @default.
- W2147360897 hasRelatedWork W1531916091 @default.
- W2147360897 hasRelatedWork W1972566534 @default.
- W2147360897 hasRelatedWork W2012022623 @default.
- W2147360897 hasRelatedWork W2012519498 @default.
- W2147360897 hasRelatedWork W2018607502 @default.
- W2147360897 hasRelatedWork W2043010760 @default.
- W2147360897 hasRelatedWork W2047446648 @default.
- W2147360897 hasRelatedWork W2053736563 @default.
- W2147360897 hasRelatedWork W2054902503 @default.
- W2147360897 hasRelatedWork W2100465511 @default.
- W2147360897 hasRelatedWork W2121621013 @default.
- W2147360897 hasRelatedWork W2132403739 @default.
- W2147360897 hasRelatedWork W2154997486 @default.
- W2147360897 hasRelatedWork W2157271398 @default.
- W2147360897 hasRelatedWork W2169529937 @default.
- W2147360897 hasRelatedWork W2747929652 @default.
- W2147360897 hasRelatedWork W3010724028 @default.
- W2147360897 hasVolume "53" @default.