FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147377106> ?p ?o ?g. }

• W2147377106 endingPage "1174.e4" @default.
• W2147377106 startingPage "1167" @default.
• W2147377106 abstract "ObjectiveTo study the expression of insulin signaling–related genes and oxidative stress markers in the visceral adipose tissue obtained from polycystic ovary syndrome (PCOS) patients and healthy control subjects and to investigate the relationships among abdominal obesity, insulin resistance, and oxidative stress at the tissue level.DesignCase-control study.SettingUniversity teaching hospital.Patient(s)In total, 30 PCOS patients and 30 healthy control subjects, who underwent laparoscopic surgery, were included in the study.Intervention(s)Abdominal obesity was defined based on waist circumference (WC). The homeostasis model index was used to assess insulin resistance (HOMA-IR).Main Outcome Measure(s)Gene expression of glucose transporter 4 (GLUT4) and insulin receptor substrate 1 (IRS1) in visceral adipose tissue (VAT) and the parameters of oxidative stress, such as superoxide dismutase, enzyme glutathione reductase, and dimethylarginine, were measured, and the expression of protein oxidative damage product 3-nitro-tyrosine residues (nitrotyrosine) in VAT was identified with the use of immunohistochemistry.Result(s)PCOS was associated with lower expression of GLUT4 and IRS1 and a higher level of oxidative stress in VAT, which was strongly correlated with WC and HOMA-IR. Presence of abdominal obesity further intensified the correlations observed in our measurements. The nitrotyrosine expression in VAT was stronger in PCOS patients.Conclusion(s)The strong correlation of insulin resistance with oxidative stress at the VAT level suggests that local oxidative stress and abnormalities of insulin signaling in adipose tissue play critical roles in the pathogenesis of PCOS. To study the expression of insulin signaling–related genes and oxidative stress markers in the visceral adipose tissue obtained from polycystic ovary syndrome (PCOS) patients and healthy control subjects and to investigate the relationships among abdominal obesity, insulin resistance, and oxidative stress at the tissue level. Case-control study. University teaching hospital. In total, 30 PCOS patients and 30 healthy control subjects, who underwent laparoscopic surgery, were included in the study. Abdominal obesity was defined based on waist circumference (WC). The homeostasis model index was used to assess insulin resistance (HOMA-IR). Gene expression of glucose transporter 4 (GLUT4) and insulin receptor substrate 1 (IRS1) in visceral adipose tissue (VAT) and the parameters of oxidative stress, such as superoxide dismutase, enzyme glutathione reductase, and dimethylarginine, were measured, and the expression of protein oxidative damage product 3-nitro-tyrosine residues (nitrotyrosine) in VAT was identified with the use of immunohistochemistry. PCOS was associated with lower expression of GLUT4 and IRS1 and a higher level of oxidative stress in VAT, which was strongly correlated with WC and HOMA-IR. Presence of abdominal obesity further intensified the correlations observed in our measurements. The nitrotyrosine expression in VAT was stronger in PCOS patients. The strong correlation of insulin resistance with oxidative stress at the VAT level suggests that local oxidative stress and abnormalities of insulin signaling in adipose tissue play critical roles in the pathogenesis of PCOS." @default.
• W2147377106 created "2016-06-24" @default.
• W2147377106 creator A5002859742 @default.
• W2147377106 creator A5034021177 @default.
• W2147377106 creator A5037989560 @default.
• W2147377106 date "2014-10-01" @default.
• W2147377106 modified "2023-10-01" @default.
• W2147377106 title "Association of abdominal obesity, insulin resistance, and oxidative stress in adipose tissue in women with polycystic ovary syndrome" @default.
• W2147377106 cites W1511064210 @default.
• W2147377106 cites W1580117062 @default.
• W2147377106 cites W1967263394 @default.
• W2147377106 cites W1981381501 @default.
• W2147377106 cites W1981665764 @default.
• W2147377106 cites W1986962958 @default.
• W2147377106 cites W1996318348 @default.
• W2147377106 cites W2010589477 @default.
• W2147377106 cites W2015252890 @default.
• W2147377106 cites W2026071202 @default.
• W2147377106 cites W2031466390 @default.
• W2147377106 cites W2036189179 @default.
• W2147377106 cites W2039228281 @default.
• W2147377106 cites W2047242389 @default.
• W2147377106 cites W2061832335 @default.
• W2147377106 cites W2062441598 @default.
• W2147377106 cites W2083990676 @default.
• W2147377106 cites W2084033509 @default.
• W2147377106 cites W2086102771 @default.
• W2147377106 cites W2091641501 @default.
• W2147377106 cites W2098219895 @default.
• W2147377106 cites W2100067039 @default.
• W2147377106 cites W2101316067 @default.
• W2147377106 cites W2104028637 @default.
• W2147377106 cites W2108067228 @default.
• W2147377106 cites W2115437409 @default.
• W2147377106 cites W2118106972 @default.
• W2147377106 cites W2118574229 @default.
• W2147377106 cites W2124861138 @default.
• W2147377106 cites W2125289626 @default.
• W2147377106 cites W2135136722 @default.
• W2147377106 cites W2136448843 @default.
• W2147377106 cites W2139471180 @default.
• W2147377106 cites W2146102404 @default.
• W2147377106 cites W2160234571 @default.
• W2147377106 cites W2324024668 @default.
• W2147377106 doi "https://doi.org/10.1016/j.fertnstert.2014.06.027" @default.
• W2147377106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25064406" @default.
• W2147377106 hasPublicationYear "2014" @default.
• W2147377106 type Work @default.
• W2147377106 sameAs 2147377106 @default.
• W2147377106 citedByCount "59" @default.
• W2147377106 countsByYear W21473771062014 @default.
• W2147377106 countsByYear W21473771062015 @default.
• W2147377106 countsByYear W21473771062016 @default.
• W2147377106 countsByYear W21473771062017 @default.
• W2147377106 countsByYear W21473771062018 @default.
• W2147377106 countsByYear W21473771062019 @default.
• W2147377106 countsByYear W21473771062020 @default.
• W2147377106 countsByYear W21473771062021 @default.
• W2147377106 countsByYear W21473771062022 @default.
• W2147377106 countsByYear W21473771062023 @default.
• W2147377106 crossrefType "journal-article" @default.
• W2147377106 hasAuthorship W2147377106A5002859742 @default.
• W2147377106 hasAuthorship W2147377106A5034021177 @default.
• W2147377106 hasAuthorship W2147377106A5037989560 @default.
• W2147377106 hasBestOaLocation W21473771061 @default.
• W2147377106 hasConcept C112446052 @default.
• W2147377106 hasConcept C126322002 @default.
• W2147377106 hasConcept C134018914 @default.
• W2147377106 hasConcept C171089720 @default.
• W2147377106 hasConcept C201624660 @default.
• W2147377106 hasConcept C2776151105 @default.
• W2147377106 hasConcept C2776188179 @default.
• W2147377106 hasConcept C2777391703 @default.
• W2147377106 hasConcept C2777622882 @default.
• W2147377106 hasConcept C2777693730 @default.
• W2147377106 hasConcept C2779306644 @default.
• W2147377106 hasConcept C2779385521 @default.
• W2147377106 hasConcept C2780578515 @default.
• W2147377106 hasConcept C3018442814 @default.
• W2147377106 hasConcept C519581460 @default.
• W2147377106 hasConcept C555293320 @default.
• W2147377106 hasConcept C71924100 @default.
• W2147377106 hasConcept C86803240 @default.
• W2147377106 hasConceptScore W2147377106C112446052 @default.
• W2147377106 hasConceptScore W2147377106C126322002 @default.
• W2147377106 hasConceptScore W2147377106C134018914 @default.
• W2147377106 hasConceptScore W2147377106C171089720 @default.
• W2147377106 hasConceptScore W2147377106C201624660 @default.
• W2147377106 hasConceptScore W2147377106C2776151105 @default.
• W2147377106 hasConceptScore W2147377106C2776188179 @default.
• W2147377106 hasConceptScore W2147377106C2777391703 @default.
• W2147377106 hasConceptScore W2147377106C2777622882 @default.
• W2147377106 hasConceptScore W2147377106C2777693730 @default.
• W2147377106 hasConceptScore W2147377106C2779306644 @default.
• W2147377106 hasConceptScore W2147377106C2779385521 @default.
• W2147377106 hasConceptScore W2147377106C2780578515 @default.
• W2147377106 hasConceptScore W2147377106C3018442814 @default.
• W2147377106 hasConceptScore W2147377106C519581460 @default.

• next