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- W2147379979 abstract "Neurogenesis in the hippocampus is characterized by the birth of thousand of cells that generate neurons throughout life. The fate of these adult newborn neurons depends on life experiences. In particular, spatial learning promotes the survival and death of new neurons. Whether learning influences the development of the dendritic tree of the surviving neurons (a key parameter for synaptic integration and signal processing) is unknown. Here we show that learning accelerates the maturation of their dendritic trees and their integration into the hippocampal network. We demonstrate that these learning effects on dendritic arbors are homeostatically regulated, persist for several months, and are specific to neurons born during adulthood. Finally, we show that this dendritic shaping depends on the cognitive demand and relies on the activation of NMDA receptors. In the search for the structural changes underlying long-term memory, these findings lead to the conclusion that shaping neo-networks is important in forming spatial memories." @default.
- W2147379979 created "2016-06-24" @default.
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- W2147379979 date "2010-04-07" @default.
- W2147379979 modified "2023-10-08" @default.
- W2147379979 title "Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons" @default.
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- W2147379979 doi "https://doi.org/10.1073/pnas.0914613107" @default.
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