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- W2147386687 abstract "Summary Investigations on the pathogenicity of Listeria strains by use of a continuous cell line as a replacement of animal experiment Culture filtrates of 38 strains of Listeria (L.) monocytogenes and of 4 strains of L. ivanovii were all cytotoxic for the vero cell line. Culture filtrates from 35 strains of L. innocua , 12 strains of L. seeligeri , 5 strains of L. welshimeri and 4 strains of L. grayi showed no cytotoxicity for the continuous cell line vero. The use of continuous cell lines permits to distinguish between pathogenic and non‐pathogenic Listeria strains and seems to be a suitable method to replace the mouse pathogenicity test or the fertilized hen's eggs test. Zusammenfassung Kulturfiltrate von 38 Listeria (L.) monocytogenes ‐Stämmen sowie von 4 L. ivanovii ‐Stämmen erwiesen sich als zytotoxisch für die Vero‐Zellkultur, nicht dagegen die Kulturfiltrate von 34 L. innocua‐ , 12 L. seeligeri ‐, 5 L. welshimeri‐ und 4 L. grayi ‐Stämmen. Die Verwendung von permanenten Zellinien, die eine Unterscheidung zwischen pathogenen und apathogenen Listerien‐Stämmen ermöglicht, scheint geeignet zu sein, den Mäusepathogenitätstest oder den Pathogenitätstest am bebrüteten Hühnerei zu ersetzen." @default.
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- W2147386687 date "1990-01-12" @default.
- W2147386687 modified "2023-10-11" @default.
- W2147386687 title "Zum Nachweis der Pathogenität von Listerien mittels permanenter Zellinie als Alternative für den Tierversuch" @default.
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- W2147386687 doi "https://doi.org/10.1111/j.1439-0450.1990.tb01118.x" @default.
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