Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147407306> ?p ?o ?g. }
- W2147407306 abstract "Temporal lobe epilepsy (TLE) is a chronic neurodegenerative disease with a high prevalence of psychiatric disorders. Temporal neocortex contributes to either seizure propagation or generation in TLE, a situation that has been associated with alterations of the γ-aminobutyric acid (GABA) system. On the other hand, an impaired neurotransmission mediated by GABA in temporal neocortex has also been involved with the pathophysiology of psychiatric disorders. In spite of these situations, the role of the necortical GABA system in the comorbidity of TLE and mood disorders has not been investigated. The present study was designed to identify alterations in the GABA system such as: binding to GABAA and GABAB receptors and benzodiazepine site, the tissue content of GABA and the expression of the mRNA encoding the α1-6, β1-3 and γ GABAA subunits, in the temporal neocortex of surgically treated patients with TLE with and without anxiety and/or depression. Neocortex of patients with TLE and comorbid anxiety and/or depression showed increased expression of the mRNA encoding the γ2-subunit, reduced GABAB-induced G protein activation in spite of elevated GABAB binding, and lower tissue content of GABA when compared to autopsy controls. Some of these changes significantly correlated with seizure frequency and duration of epilepsy. The results obtained suggest a dysfunction of the GABAergic neurotransmission in temporal neocortex of patients with TLE and comorbid anxiety and/or depression that could be also influenced by clinical factors such as seizure frequency and duration of illness." @default.
- W2147407306 created "2016-06-24" @default.
- W2147407306 creator A5009723089 @default.
- W2147407306 creator A5015581746 @default.
- W2147407306 creator A5018185234 @default.
- W2147407306 creator A5018926002 @default.
- W2147407306 creator A5021451368 @default.
- W2147407306 creator A5024373687 @default.
- W2147407306 creator A5036524437 @default.
- W2147407306 creator A5043071972 @default.
- W2147407306 creator A5074323215 @default.
- W2147407306 creator A5086240611 @default.
- W2147407306 date "2015-01-05" @default.
- W2147407306 modified "2023-09-28" @default.
- W2147407306 title "GABAergic Alterations in Neocortex of Patients with Pharmacoresistant Temporal Lobe Epilepsy Can Explain the Comorbidity of Anxiety and Depression: The Potential Impact of Clinical Factors" @default.
- W2147407306 cites W1498751696 @default.
- W2147407306 cites W1775749144 @default.
- W2147407306 cites W1860455432 @default.
- W2147407306 cites W1900558362 @default.
- W2147407306 cites W1944684909 @default.
- W2147407306 cites W1964635765 @default.
- W2147407306 cites W1965736251 @default.
- W2147407306 cites W1972286673 @default.
- W2147407306 cites W1989615119 @default.
- W2147407306 cites W1994775090 @default.
- W2147407306 cites W1998229125 @default.
- W2147407306 cites W2011118886 @default.
- W2147407306 cites W2017854164 @default.
- W2147407306 cites W2018765333 @default.
- W2147407306 cites W2020388103 @default.
- W2147407306 cites W2024862524 @default.
- W2147407306 cites W2025495248 @default.
- W2147407306 cites W2026031190 @default.
- W2147407306 cites W2027950087 @default.
- W2147407306 cites W2030301599 @default.
- W2147407306 cites W2041424059 @default.
- W2147407306 cites W2045936429 @default.
- W2147407306 cites W2051267844 @default.
- W2147407306 cites W2052105077 @default.
- W2147407306 cites W2052381603 @default.
- W2147407306 cites W2052731679 @default.
- W2147407306 cites W2053225896 @default.
- W2147407306 cites W2056945518 @default.
- W2147407306 cites W2058732516 @default.
- W2147407306 cites W2060890501 @default.
- W2147407306 cites W2064536606 @default.
- W2147407306 cites W2077168473 @default.
- W2147407306 cites W2077441040 @default.
- W2147407306 cites W2077778101 @default.
- W2147407306 cites W2081735681 @default.
- W2147407306 cites W2084334584 @default.
- W2147407306 cites W2085316335 @default.
- W2147407306 cites W2088935772 @default.
- W2147407306 cites W2093202825 @default.
- W2147407306 cites W2095060637 @default.
- W2147407306 cites W2108543063 @default.
- W2147407306 cites W2116394679 @default.
- W2147407306 cites W2125675050 @default.
- W2147407306 cites W2126017934 @default.
- W2147407306 cites W2129028793 @default.
- W2147407306 cites W2133371501 @default.
- W2147407306 cites W2137110871 @default.
- W2147407306 cites W2137319519 @default.
- W2147407306 cites W2137545323 @default.
- W2147407306 cites W2147324517 @default.
- W2147407306 cites W2153246714 @default.
- W2147407306 cites W2158327608 @default.
- W2147407306 cites W2159750050 @default.
- W2147407306 cites W2160408625 @default.
- W2147407306 cites W2166306916 @default.
- W2147407306 cites W2169259200 @default.
- W2147407306 cites W2169937206 @default.
- W2147407306 cites W2170867393 @default.
- W2147407306 cites W2314521814 @default.
- W2147407306 cites W2443549370 @default.
- W2147407306 doi "https://doi.org/10.3389/fncel.2014.00442" @default.
- W2147407306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4283637" @default.
- W2147407306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25601827" @default.
- W2147407306 hasPublicationYear "2015" @default.
- W2147407306 type Work @default.
- W2147407306 sameAs 2147407306 @default.
- W2147407306 citedByCount "28" @default.
- W2147407306 countsByYear W21474073062016 @default.
- W2147407306 countsByYear W21474073062017 @default.
- W2147407306 countsByYear W21474073062018 @default.
- W2147407306 countsByYear W21474073062019 @default.
- W2147407306 countsByYear W21474073062020 @default.
- W2147407306 countsByYear W21474073062021 @default.
- W2147407306 countsByYear W21474073062022 @default.
- W2147407306 countsByYear W21474073062023 @default.
- W2147407306 crossrefType "journal-article" @default.
- W2147407306 hasAuthorship W2147407306A5009723089 @default.
- W2147407306 hasAuthorship W2147407306A5015581746 @default.
- W2147407306 hasAuthorship W2147407306A5018185234 @default.
- W2147407306 hasAuthorship W2147407306A5018926002 @default.
- W2147407306 hasAuthorship W2147407306A5021451368 @default.
- W2147407306 hasAuthorship W2147407306A5024373687 @default.
- W2147407306 hasAuthorship W2147407306A5036524437 @default.
- W2147407306 hasAuthorship W2147407306A5043071972 @default.
- W2147407306 hasAuthorship W2147407306A5074323215 @default.