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• W2147483797 startingPage "825" @default.
• W2147483797 abstract "Abstract Purpose To compare the MRI features between estrogen receptor (ER) positive and negative breast cancers. Materials and Methods Breast MRI of 90 consecutive patients confirmed with invasive ductal carcinoma (IDC), 51 ER positive and 39 ER negative, were analyzed. The tumor morphology and dynamic contrast‐enhanced (DCE) kinetics were evaluated based on the American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI‐RADS) MRI lexicon and compared. Enlarged axillary lymph nodes on MRI and choline (Cho) detection using MR spectroscopy (MRS) were also analyzed and compared. For patients receiving axillary node dissection the pathological nodal status was also compared. Results ER negative breast cancer had bigger tumors compared to ER positive cancer (3.6 ± 2.0 cm vs. 1.8 ± 1.3 cm, P < 0.00005). ER negative cancer was more likely to exhibit nonmass type enhancements compared to ER positive cancer ( P < 0.005). Enlarged axillary lymph nodes were more frequently identified on MRI in ER negative compared to ER positive patients ( P < 0.05). After excluding patients undergoing neoadjuvant chemotherapy, axiliary lymph node status did not show significant difference between ER positive and ER negative cancer on MRI and pathology. ER negative cancer was more likely to show the malignant type enhancement kinetics ( P = 0.15), rim enhancement ( P = 0.15), and Cho detection on MRS ( P = 0.23) compared to ER positive cancer, but it did not reach a level of statistical significance. Conclusion ER negative breast cancer was more aggressive, with larger tumor size, more non‐mass‐type enhancement lesions, and a higher percentage showing enlarged axillary nodes on MRI. These features might be related to its poorer cellular differentiation and/or a higher angiogenesis. J. Magn. Reson. Imaging 2008;27:825–833. © 2008 Wiley‐Liss, Inc." @default.
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• W2147483797 date "2008-03-27" @default.
• W2147483797 modified "2023-10-16" @default.
• W2147483797 title "Estrogen receptor and breast MR imaging features: A correlation study" @default.
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• W2147483797 doi "https://doi.org/10.1002/jmri.21330" @default.
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