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• W2147491346 startingPage "684" @default.
• W2147491346 abstract "The energetic contributions of hydrogen bonding to protein folding are still unclear, despite more than 70 years of study. This is due partly to the difficulty of extracting thermodynamic information about specific interactions from protein mutagenesis data and partly to the context dependence of hydrogen bond strengths. Herein, we test the hypothesis that hydrogen bond strengths depend on the polarity of their microenvironment, with stronger hydrogen bonds forming in nonpolar surroundings. Double-mutant cycle analysis using a combination of amide-to-ester backbone mutagenesis and traditional side chain mutagenesis revealed that hydrogen bonds can be stronger by up to 1.2 kcal mol(-1) when they are sequestered in hydrophobic surroundings than when they are solvent exposed. Such large coupling energies between hydrogen bond strengths and local polarity suggest that the context dependence of hydrogen bond strengths must be accounted for in any comprehensive account of the forces responsible for protein folding." @default.
• W2147491346 created "2016-06-24" @default.
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• W2147491346 date "2009-06-14" @default.
• W2147491346 modified "2023-09-30" @default.
• W2147491346 title "Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins" @default.
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• W2147491346 doi "https://doi.org/10.1038/nsmb.1610" @default.
• W2147491346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2754385" @default.
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