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• W2147491566 startingPage "49" @default.
• W2147491566 abstract "One of the fundamental issues in RNA splicing research is represented by understanding how the spliceosome can successfully define exons and introns in a huge variety of pre-mRNA molecules with nucleotide-precision. Since its first description, researchers in this field have identified and characterized many fundamental elements and players capable of affecting the splicing process, both in a negative and positive manner. Indeed, it can be argued that today we know a great deal about the forces that make an exon, an exon and an intron, an intron. As will be discussed in this review, these decisions are a result of a complex combinatorial control resulting from many different factors/influences. Most importantly, these influences act across several levels of complexity starting from the relatively simple interaction between two consensus 5' and 3' splice sites to much more complex factors: such as the interplay between silencer or enhancer sequences, transcriptional processivity, genomic milieu, nucleosome positioning, and histone modifications at the chromatin level. Depending on local contexts, all these factors will act either antagonistically or synergistically to decide the exon/intron fate of any given RNA sequence. At present, however, what we still lack is a precise understanding of how all these processes add up to help the spliceosome reach a decision. Therefore, it is expected that future challenges in splicing research will be the careful characterization of all these influences to improve our ability to predict splicing choices in different organisms or in specific contexts." @default.
• W2147491566 created "2016-06-24" @default.
• W2147491566 creator A5009167796 @default.
• W2147491566 creator A5032436476 @default.
• W2147491566 creator A5061086056 @default.
• W2147491566 date "2012-10-08" @default.
• W2147491566 modified "2023-10-10" @default.
• W2147491566 title "Exon and intron definition in pre-mRNA splicing" @default.
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• W2147491566 doi "https://doi.org/10.1002/wrna.1140" @default.
• W2147491566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23044818" @default.
• W2147491566 hasPublicationYear "2012" @default.
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