FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147506377> ?p ?o ?g. }

• W2147506377 endingPage "2621" @default.
• W2147506377 startingPage "2613" @default.
• W2147506377 abstract "Background. Successful xenograft transplantation faces several obstacles including the presence of xenoantibodies, natural killer cell- and macrophage-mediated rejection, and T lymphocyte activation. Methods. A mouse-to-rat cardiac xenograft model was used to examine the synergistic effect of anti-T cell receptor (TCR) monoclonal antibodies (mAb) and 15-deoxyspergualin (DSG) on graft survival. Results. Pretransplantation injections (days −5, −3, and −1) of anti-TCR mAb (500 μg/kg/day) combined with continuous i.p. infusion of DSG (5 mg/kg/day) from day −7 to 28 significantly prolonged graft survival compared to untreated controls (3.3±0.5 vs. 44.2±5.6 days, P <0.001). Postoperative splenectomy combined with discontinuation of all other treatment on day 28 enhanced graft survival in rats treated with anti-TCR mAb and DSG to 71.0±2.5 days. Histological examination of grafts showed characteristic signs of vascular rejection: interstitial edema and hemorrhage, and polymorphonuclear cell infiltration. Anti-mouse antibody titers in recipients were increased upon rejection in each group that received a xenograft. Flow cytometry analysis showed a markedly decreased T cell population and a relatively increased mature B cell population (IgMbright/IgDdull) in spleens of rats treated with anti-TCR mAb and DSG on day 28. Conclusions. The mechanism of prolonged xenograft survival in this model may include inhibition of antibody production by arrest of B-cell maturation during development from IgMdull/IgDbright mature B cells to antibody producing cells, and inhibition of T cell activation. The rejection seen in our model may be caused by xenoreactive antibodies and may be associated with T cells, natural killer cells, and macrophages." @default.
• W2147506377 created "2016-06-24" @default.
• W2147506377 creator A5008910767 @default.
• W2147506377 creator A5023708308 @default.
• W2147506377 creator A5023887835 @default.
• W2147506377 creator A5030996780 @default.
• W2147506377 creator A5031769786 @default.
• W2147506377 creator A5033614902 @default.
• W2147506377 creator A5088097313 @default.
• W2147506377 creator A5089628194 @default.
• W2147506377 creator A5089924378 @default.
• W2147506377 date "2000-06-01" @default.
• W2147506377 modified "2023-09-24" @default.
• W2147506377 title "SYNERGISTIC EFFECT OF ANTI-T CELL RECEPTOR MONOCLONAL ANTIBODY AND 15-DEOXYSPERGUALIN ON CARDIAC XENOGRAFT SURVIVAL IN A MOUSE-TO-RAT MODEL1" @default.
• W2147506377 cites W1965130060 @default.
• W2147506377 cites W1969535537 @default.
• W2147506377 cites W1970652129 @default.
• W2147506377 cites W1999247918 @default.
• W2147506377 cites W2007516625 @default.
• W2147506377 cites W2015516487 @default.
• W2147506377 cites W2018204952 @default.
• W2147506377 cites W2020903680 @default.
• W2147506377 cites W2022143079 @default.
• W2147506377 cites W2022809446 @default.
• W2147506377 cites W2028146382 @default.
• W2147506377 cites W2028537846 @default.
• W2147506377 cites W2028988139 @default.
• W2147506377 cites W2030410237 @default.
• W2147506377 cites W2030906052 @default.
• W2147506377 cites W2033421066 @default.
• W2147506377 cites W2046644549 @default.
• W2147506377 cites W2052938585 @default.
• W2147506377 cites W2057454749 @default.
• W2147506377 cites W2060109555 @default.
• W2147506377 cites W2061284405 @default.
• W2147506377 cites W2064822730 @default.
• W2147506377 cites W2064835686 @default.
• W2147506377 cites W2067013431 @default.
• W2147506377 cites W2069359055 @default.
• W2147506377 cites W2073842018 @default.
• W2147506377 cites W2075809176 @default.
• W2147506377 cites W2075938493 @default.
• W2147506377 cites W2079717284 @default.
• W2147506377 cites W2088143812 @default.
• W2147506377 cites W2088964434 @default.
• W2147506377 cites W2124895467 @default.
• W2147506377 cites W2137844313 @default.
• W2147506377 cites W2146821092 @default.
• W2147506377 cites W2151567849 @default.
• W2147506377 cites W2314738454 @default.
• W2147506377 cites W4241975579 @default.
• W2147506377 doi "https://doi.org/10.1097/00007890-200006270-00023" @default.
• W2147506377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10910285" @default.
• W2147506377 hasPublicationYear "2000" @default.
• W2147506377 type Work @default.
• W2147506377 sameAs 2147506377 @default.
• W2147506377 citedByCount "10" @default.
• W2147506377 countsByYear W21475063772020 @default.
• W2147506377 crossrefType "journal-article" @default.
• W2147506377 hasAuthorship W2147506377A5008910767 @default.
• W2147506377 hasAuthorship W2147506377A5023708308 @default.
• W2147506377 hasAuthorship W2147506377A5023887835 @default.
• W2147506377 hasAuthorship W2147506377A5030996780 @default.
• W2147506377 hasAuthorship W2147506377A5031769786 @default.
• W2147506377 hasAuthorship W2147506377A5033614902 @default.
• W2147506377 hasAuthorship W2147506377A5088097313 @default.
• W2147506377 hasAuthorship W2147506377A5089628194 @default.
• W2147506377 hasAuthorship W2147506377A5089924378 @default.
• W2147506377 hasBestOaLocation W21475063771 @default.
• W2147506377 hasConcept C126322002 @default.
• W2147506377 hasConcept C159654299 @default.
• W2147506377 hasConcept C16685009 @default.
• W2147506377 hasConcept C19317047 @default.
• W2147506377 hasConcept C203014093 @default.
• W2147506377 hasConcept C2776090121 @default.
• W2147506377 hasConcept C2908647359 @default.
• W2147506377 hasConcept C2911091166 @default.
• W2147506377 hasConcept C542903549 @default.
• W2147506377 hasConcept C553184892 @default.
• W2147506377 hasConcept C71924100 @default.
• W2147506377 hasConcept C8891405 @default.
• W2147506377 hasConcept C98274493 @default.
• W2147506377 hasConcept C99454951 @default.
• W2147506377 hasConceptScore W2147506377C126322002 @default.
• W2147506377 hasConceptScore W2147506377C159654299 @default.
• W2147506377 hasConceptScore W2147506377C16685009 @default.
• W2147506377 hasConceptScore W2147506377C19317047 @default.
• W2147506377 hasConceptScore W2147506377C203014093 @default.
• W2147506377 hasConceptScore W2147506377C2776090121 @default.
• W2147506377 hasConceptScore W2147506377C2908647359 @default.
• W2147506377 hasConceptScore W2147506377C2911091166 @default.
• W2147506377 hasConceptScore W2147506377C542903549 @default.
• W2147506377 hasConceptScore W2147506377C553184892 @default.
• W2147506377 hasConceptScore W2147506377C71924100 @default.
• W2147506377 hasConceptScore W2147506377C8891405 @default.
• W2147506377 hasConceptScore W2147506377C98274493 @default.
• W2147506377 hasConceptScore W2147506377C99454951 @default.
• W2147506377 hasIssue "12" @default.

• next