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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147513048> ?p ?o ?g. }

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• W2147513048 abstract "Hypoxia-inducible factor-1alpha (HIF-1a) is widely considered to be one of the key regulators in cancer cells. Here, we investigated a microRNA regulating expression of HIF-1a and explored its functions in clear cell renal cell carcinoma (ccRCC) cells.Western blot and reporter assays were used to assess HIF-1a as a direct target of miR-138. The effects of miR-138 or si-HIF-1a on ccRCC 786-O cells were also estimated by apoptosis analysis and cell migration assay.The data showed HIF-1a to be one target of miR-138. Futhermore, inhibition of the expression of HIF-1a with specific siRNA or miR-138 could increase apoptosis and reduce the migration of 786-O cells.miR-138 could inhibit the expression of HIF-1a and regulate the apoptosis and migration of ccRCC cells." @default.
• W2147513048 created "2016-06-24" @default.
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• W2147513048 date "2011-01-01" @default.
• W2147513048 modified "2023-10-16" @default.
• W2147513048 title "MiR-138 suppresses expression of hypoxia-inducible factor 1α (HIF-1α) in clear cell renal cell carcinoma 786-O cells." @default.
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• W2147513048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21875287" @default.
• W2147513048 hasPublicationYear "2011" @default.
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