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- W2147515706 endingPage "e312" @default.
- W2147515706 startingPage "e312" @default.
- W2147515706 abstract "Although the molting cycle is a hallmark of insects and nematodes, neither the endocrine control of molting via size, stage, and nutritional inputs nor the enzymatic mechanism for synthesis and release of the exoskeleton is well understood. Here, we identify endocrine and enzymatic regulators of molting in C. elegans through a genome-wide RNA-interference screen. Products of the 159 genes discovered include annotated transcription factors, secreted peptides, transmembrane proteins, and extracellular matrix enzymes essential for molting. Fusions between several genes and green fluorescent protein show a pulse of expression before each molt in epithelial cells that synthesize the exoskeleton, indicating that the corresponding proteins are made in the correct time and place to regulate molting. We show further that inactivation of particular genes abrogates expression of the green fluorescent protein reporter genes, revealing regulatory networks that might couple the expression of genes essential for molting to endocrine cues. Many molting genes are conserved in parasitic nematodes responsible for human disease, and thus represent attractive targets for pesticide and pharmaceutical development." @default.
- W2147515706 created "2016-06-24" @default.
- W2147515706 creator A5040551760 @default.
- W2147515706 creator A5064984589 @default.
- W2147515706 creator A5066998461 @default.
- W2147515706 date "2005-08-30" @default.
- W2147515706 modified "2023-10-08" @default.
- W2147515706 title "Functional Genomic Analysis of C. elegans Molting" @default.
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- W2147515706 doi "https://doi.org/10.1371/journal.pbio.0030312" @default.
- W2147515706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1233573" @default.
- W2147515706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16122351" @default.
- W2147515706 hasPublicationYear "2005" @default.