FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147521434> ?p ?o ?g. }

• W2147521434 endingPage "643" @default.
• W2147521434 startingPage "636" @default.
• W2147521434 abstract "There is conflicting evidence regarding appropriate glycaemic targets for patients with type 2 diabetes. Here, we investigate the relationship between HbA(1c) and the risks of vascular complications and death in such patients.Eleven thousand one hundred and forty patients were randomised to intensive or standard glucose control in the Action in Diabetes and Vascular disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial. Glycaemic exposure was assessed as the mean of HbA(1c) measurements during follow-up and prior to the first event. Adjusted risks for each HbA(1c) decile were estimated using Cox models. Possible differences in the association between HbA(1c) and risks at different levels of HbA(1c) were explored using linear spline models.There was a non-linear relationship between mean HbA(1c) during follow-up and the risks of macrovascular events, microvascular events and death. Within the range of HbA(1c) studied (5.5-10.5%), there was evidence of 'thresholds', such that below HbA(1c) levels of 7.0% for macrovascular events and death, and 6.5% for microvascular events, there was no significant change in risks (all p > 0.8). Above these thresholds, the risks increased significantly: every 1% higher HbA(1c) level was associated with a 38% higher risk of a macrovascular event, a 40% higher risk of a microvascular event and a 38% higher risk of death (all p < 0.0001).In patients with type 2 diabetes, HbA(1c) levels were associated with lower risks of macrovascular events and death down to a threshold of 7.0% and microvascular events down to a threshold of 6.5%. There was no evidence of lower risks below these levels but neither was there clear evidence of harm." @default.
• W2147521434 created "2016-06-24" @default.
• W2147521434 creator A5000309355 @default.
• W2147521434 creator A5022273017 @default.
• W2147521434 creator A5025572908 @default.
• W2147521434 creator A5026262569 @default.
• W2147521434 creator A5037890696 @default.
• W2147521434 creator A5039186899 @default.
• W2147521434 creator A5048460362 @default.
• W2147521434 creator A5052297925 @default.
• W2147521434 creator A5052889466 @default.
• W2147521434 creator A5054084985 @default.
• W2147521434 creator A5055394217 @default.
• W2147521434 creator A5065175958 @default.
• W2147521434 creator A5069771802 @default.
• W2147521434 creator A5072011562 @default.
• W2147521434 creator A5075162144 @default.
• W2147521434 creator A5080414613 @default.
• W2147521434 creator A5085682074 @default.
• W2147521434 creator A5087067945 @default.
• W2147521434 date "2011-12-21" @default.
• W2147521434 modified "2023-10-14" @default.
• W2147521434 title "Association of HbA1c levels with vascular complications and death in patients with type 2 diabetes: evidence of glycaemic thresholds" @default.
• W2147521434 cites W1526927233 @default.
• W2147521434 cites W172609984 @default.
• W2147521434 cites W179126878 @default.
• W2147521434 cites W1983269691 @default.
• W2147521434 cites W2022119612 @default.
• W2147521434 cites W2023907325 @default.
• W2147521434 cites W2035016472 @default.
• W2147521434 cites W2050532566 @default.
• W2147521434 cites W2090824142 @default.
• W2147521434 cites W2096466744 @default.
• W2147521434 cites W2103965307 @default.
• W2147521434 cites W2110418106 @default.
• W2147521434 cites W2110664743 @default.
• W2147521434 cites W2123946565 @default.
• W2147521434 cites W2147663252 @default.
• W2147521434 cites W2158666727 @default.
• W2147521434 cites W2162715993 @default.
• W2147521434 cites W4253016408 @default.
• W2147521434 doi "https://doi.org/10.1007/s00125-011-2404-1" @default.
• W2147521434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22186981" @default.
• W2147521434 hasPublicationYear "2011" @default.
• W2147521434 type Work @default.
• W2147521434 sameAs 2147521434 @default.
• W2147521434 citedByCount "256" @default.
• W2147521434 countsByYear W21475214342012 @default.
• W2147521434 countsByYear W21475214342013 @default.
• W2147521434 countsByYear W21475214342014 @default.
• W2147521434 countsByYear W21475214342015 @default.
• W2147521434 countsByYear W21475214342016 @default.
• W2147521434 countsByYear W21475214342017 @default.
• W2147521434 countsByYear W21475214342018 @default.
• W2147521434 countsByYear W21475214342019 @default.
• W2147521434 countsByYear W21475214342020 @default.
• W2147521434 countsByYear W21475214342021 @default.
• W2147521434 countsByYear W21475214342022 @default.
• W2147521434 countsByYear W21475214342023 @default.
• W2147521434 crossrefType "journal-article" @default.
• W2147521434 hasAuthorship W2147521434A5000309355 @default.
• W2147521434 hasAuthorship W2147521434A5022273017 @default.
• W2147521434 hasAuthorship W2147521434A5025572908 @default.
• W2147521434 hasAuthorship W2147521434A5026262569 @default.
• W2147521434 hasAuthorship W2147521434A5037890696 @default.
• W2147521434 hasAuthorship W2147521434A5039186899 @default.
• W2147521434 hasAuthorship W2147521434A5048460362 @default.
• W2147521434 hasAuthorship W2147521434A5052297925 @default.
• W2147521434 hasAuthorship W2147521434A5052889466 @default.
• W2147521434 hasAuthorship W2147521434A5054084985 @default.
• W2147521434 hasAuthorship W2147521434A5055394217 @default.
• W2147521434 hasAuthorship W2147521434A5065175958 @default.
• W2147521434 hasAuthorship W2147521434A5069771802 @default.
• W2147521434 hasAuthorship W2147521434A5072011562 @default.
• W2147521434 hasAuthorship W2147521434A5075162144 @default.
• W2147521434 hasAuthorship W2147521434A5080414613 @default.
• W2147521434 hasAuthorship W2147521434A5085682074 @default.
• W2147521434 hasAuthorship W2147521434A5087067945 @default.
• W2147521434 hasBestOaLocation W21475214341 @default.
• W2147521434 hasConcept C126322002 @default.
• W2147521434 hasConcept C127413603 @default.
• W2147521434 hasConcept C134018914 @default.
• W2147521434 hasConcept C164705383 @default.
• W2147521434 hasConcept C2775887513 @default.
• W2147521434 hasConcept C2777180221 @default.
• W2147521434 hasConcept C2777466421 @default.
• W2147521434 hasConcept C2778848681 @default.
• W2147521434 hasConcept C2779134260 @default.
• W2147521434 hasConcept C2780645631 @default.
• W2147521434 hasConcept C29374701 @default.
• W2147521434 hasConcept C50382708 @default.
• W2147521434 hasConcept C555293320 @default.
• W2147521434 hasConcept C71924100 @default.
• W2147521434 hasConcept C78519656 @default.
• W2147521434 hasConceptScore W2147521434C126322002 @default.
• W2147521434 hasConceptScore W2147521434C127413603 @default.
• W2147521434 hasConceptScore W2147521434C134018914 @default.
• W2147521434 hasConceptScore W2147521434C164705383 @default.

• next