Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147549649> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2147549649 endingPage "821" @default.
- W2147549649 startingPage "816" @default.
- W2147549649 abstract "Pneumocystis jirovecii pneumonia (PCP) remains a concern after organ transplantation. In 2005, the University of Kentucky (UK) Transplant Center implemented a novel dosing regimen of weekly dapsone as an alternative for patients with contraindications or intolerability to trimethoprim-sulfamethoxazole (TMP-SMZ), which remains the drug of choice. The purpose of this study was to compare the efficacy of weekly dapsone with TMP-SMZ in preventing PCP post transplantation.A single-center, cohort, retrospective review of kidney and liver transplant patients from January 2005 to December 2012 was conducted. Patients who were identified as dapsone cases were matched in a 1:1 ratio with TMP-SMZ controls based on type of transplant, age, primary diagnosis, and gender. The primary endpoint assessed was the diagnosis of PCP at 6 and 12 months post transplant.A total of 158 patients were included in the study. No documented cases of PCP occurred in either study group at 6 or 12 months (P = 1.0). In dapsone patients 35 (44%) cases of breakthrough infection occurred, compared to 24 (30%) in the TMP-SMZ group (P = 0.07) within 12 months post transplant. In the dapsone group, 52 (65%) patients were hospitalized within 6 months post transplant compared to 36 (46%) patients in the TMP-SMZ group (P = 0.01). Similar results were seen in patients hospitalized within 12 months post transplant; 49% of patients were switched from TMP-SMZ to dapsone owing to renal dysfunction.No documented cases of PCP occurred in either study group. Future studies are warranted to show the efficacy of weekly dapsone dosing compared to other PCP prophylaxis regimens." @default.
- W2147549649 created "2016-06-24" @default.
- W2147549649 creator A5021527601 @default.
- W2147549649 creator A5022339590 @default.
- W2147549649 creator A5061636052 @default.
- W2147549649 creator A5086058684 @default.
- W2147549649 creator A5091331859 @default.
- W2147549649 date "2015-11-25" @default.
- W2147549649 modified "2023-10-16" @default.
- W2147549649 title "Efficacy of once-weekly dapsone dosing for<i>Pneumocystis jirovecii</i>pneumonia prophylaxis post transplantation" @default.
- W2147549649 cites W1495954281 @default.
- W2147549649 cites W1994355974 @default.
- W2147549649 cites W1994946938 @default.
- W2147549649 cites W2091955273 @default.
- W2147549649 cites W2107746427 @default.
- W2147549649 cites W2108437703 @default.
- W2147549649 cites W2122478002 @default.
- W2147549649 doi "https://doi.org/10.1111/tid.12457" @default.
- W2147549649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26369753" @default.
- W2147549649 hasPublicationYear "2015" @default.
- W2147549649 type Work @default.
- W2147549649 sameAs 2147549649 @default.
- W2147549649 citedByCount "12" @default.
- W2147549649 countsByYear W21475496492016 @default.
- W2147549649 countsByYear W21475496492017 @default.
- W2147549649 countsByYear W21475496492018 @default.
- W2147549649 countsByYear W21475496492019 @default.
- W2147549649 countsByYear W21475496492020 @default.
- W2147549649 countsByYear W21475496492021 @default.
- W2147549649 countsByYear W21475496492022 @default.
- W2147549649 crossrefType "journal-article" @default.
- W2147549649 hasAuthorship W2147549649A5021527601 @default.
- W2147549649 hasAuthorship W2147549649A5022339590 @default.
- W2147549649 hasAuthorship W2147549649A5061636052 @default.
- W2147549649 hasAuthorship W2147549649A5086058684 @default.
- W2147549649 hasAuthorship W2147549649A5091331859 @default.
- W2147549649 hasConcept C126322002 @default.
- W2147549649 hasConcept C141071460 @default.
- W2147549649 hasConcept C16005928 @default.
- W2147549649 hasConcept C167135981 @default.
- W2147549649 hasConcept C168563851 @default.
- W2147549649 hasConcept C203092338 @default.
- W2147549649 hasConcept C2777160144 @default.
- W2147549649 hasConcept C2777288759 @default.
- W2147549649 hasConcept C2777559004 @default.
- W2147549649 hasConcept C2777640609 @default.
- W2147549649 hasConcept C2777914695 @default.
- W2147549649 hasConcept C2780728791 @default.
- W2147549649 hasConcept C2781413609 @default.
- W2147549649 hasConcept C2911091166 @default.
- W2147549649 hasConcept C501593827 @default.
- W2147549649 hasConcept C71924100 @default.
- W2147549649 hasConcept C86803240 @default.
- W2147549649 hasConcept C89423630 @default.
- W2147549649 hasConceptScore W2147549649C126322002 @default.
- W2147549649 hasConceptScore W2147549649C141071460 @default.
- W2147549649 hasConceptScore W2147549649C16005928 @default.
- W2147549649 hasConceptScore W2147549649C167135981 @default.
- W2147549649 hasConceptScore W2147549649C168563851 @default.
- W2147549649 hasConceptScore W2147549649C203092338 @default.
- W2147549649 hasConceptScore W2147549649C2777160144 @default.
- W2147549649 hasConceptScore W2147549649C2777288759 @default.
- W2147549649 hasConceptScore W2147549649C2777559004 @default.
- W2147549649 hasConceptScore W2147549649C2777640609 @default.
- W2147549649 hasConceptScore W2147549649C2777914695 @default.
- W2147549649 hasConceptScore W2147549649C2780728791 @default.
- W2147549649 hasConceptScore W2147549649C2781413609 @default.
- W2147549649 hasConceptScore W2147549649C2911091166 @default.
- W2147549649 hasConceptScore W2147549649C501593827 @default.
- W2147549649 hasConceptScore W2147549649C71924100 @default.
- W2147549649 hasConceptScore W2147549649C86803240 @default.
- W2147549649 hasConceptScore W2147549649C89423630 @default.
- W2147549649 hasIssue "6" @default.
- W2147549649 hasLocation W21475496491 @default.
- W2147549649 hasLocation W21475496492 @default.
- W2147549649 hasOpenAccess W2147549649 @default.
- W2147549649 hasPrimaryLocation W21475496491 @default.
- W2147549649 hasRelatedWork W2009965521 @default.
- W2147549649 hasRelatedWork W2065896857 @default.
- W2147549649 hasRelatedWork W2136812515 @default.
- W2147549649 hasRelatedWork W2267805210 @default.
- W2147549649 hasRelatedWork W2338386173 @default.
- W2147549649 hasRelatedWork W2342351290 @default.
- W2147549649 hasRelatedWork W2940125879 @default.
- W2147549649 hasRelatedWork W3092728669 @default.
- W2147549649 hasRelatedWork W4235977873 @default.
- W2147549649 hasRelatedWork W4240074224 @default.
- W2147549649 hasVolume "17" @default.
- W2147549649 isParatext "false" @default.
- W2147549649 isRetracted "false" @default.
- W2147549649 magId "2147549649" @default.
- W2147549649 workType "article" @default.