Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147552610> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2147552610 abstract "Investigating the bioactivity of traditional medical remedies under the controlled conditions of a laboratory is an option to find additional applications, novel formulations or lead structures for the development of new drugs. The present work analysed the anti‑neoplastic activity of increasing polar extracts of the rainforest plant Critonia morifolia (Asteraceae) that has been successfully used as traditional remedy to treat various inflammatory conditions in the long-lasting medical tradition of the Central American Maya, which was here also confirmed in vitro. The apolar petroleum ether extract exhibited the most potent anti‑proliferative and pro‑apoptotic effects in HL‑60 cells and triggered down-regulation of Cdc25C and cyclin D1 within 30 min followed by the inhibition of c-Myc expression and the onset of caspase-3 activation within 2 h. Subsequent to these very rapid molecular responses Chk2 and H2AX became phosphorylated (γ‑H2AX) after 4 h. Analysis of the cell cycle distribution showed an accumulation of cells in the G2-M phase within 8 h and after 24 h in S-phase. This was temporally paralleled by the down-regulation of Cdc25A, Cdc25B, Wee1 and Akt. Therefore, the attenuation of cell cycle progression in the G2-M phase was consistent with the known role of Chk2 for G2-M arrest and with the role of Cdc25B in S-phase progression. These findings suggest the presence of two distinct active principles in the petroleum ether extract of C. moriflia. These facilitated the strong apoptotic response evidenced by the rapid activation of caspase-3 that was later enforced by the inhibition of the survival kinase Akt. Importantly, the efficient down-regulation of Akt, which is successfully tested in current clinical trials, is a unique property of C. morifolia." @default.
- W2147552610 created "2016-06-24" @default.
- W2147552610 creator A5000446617 @default.
- W2147552610 creator A5001077411 @default.
- W2147552610 creator A5005182579 @default.
- W2147552610 creator A5008696188 @default.
- W2147552610 creator A5011735686 @default.
- W2147552610 creator A5016487204 @default.
- W2147552610 creator A5024292426 @default.
- W2147552610 creator A5032803474 @default.
- W2147552610 creator A5033125669 @default.
- W2147552610 creator A5034572298 @default.
- W2147552610 creator A5041730682 @default.
- W2147552610 creator A5042057572 @default.
- W2147552610 creator A5050637640 @default.
- W2147552610 creator A5053576191 @default.
- W2147552610 creator A5064908718 @default.
- W2147552610 creator A5072121280 @default.
- W2147552610 creator A5085549140 @default.
- W2147552610 date "2012-03-23" @default.
- W2147552610 modified "2023-10-01" @default.
- W2147552610 title "An apolar extract of Critonia morifolia inhibits c-Myc, cyclin D1, Cdc25A, Cdc25B, Cdc25C and Akt and induces apoptosis" @default.
- W2147552610 doi "https://doi.org/10.3892/ijo.2012.1412" @default.
- W2147552610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22446629" @default.
- W2147552610 hasPublicationYear "2012" @default.
- W2147552610 type Work @default.
- W2147552610 sameAs 2147552610 @default.
- W2147552610 citedByCount "2" @default.
- W2147552610 countsByYear W21475526102017 @default.
- W2147552610 crossrefType "journal-article" @default.
- W2147552610 hasAuthorship W2147552610A5000446617 @default.
- W2147552610 hasAuthorship W2147552610A5001077411 @default.
- W2147552610 hasAuthorship W2147552610A5005182579 @default.
- W2147552610 hasAuthorship W2147552610A5008696188 @default.
- W2147552610 hasAuthorship W2147552610A5011735686 @default.
- W2147552610 hasAuthorship W2147552610A5016487204 @default.
- W2147552610 hasAuthorship W2147552610A5024292426 @default.
- W2147552610 hasAuthorship W2147552610A5032803474 @default.
- W2147552610 hasAuthorship W2147552610A5033125669 @default.
- W2147552610 hasAuthorship W2147552610A5034572298 @default.
- W2147552610 hasAuthorship W2147552610A5041730682 @default.
- W2147552610 hasAuthorship W2147552610A5042057572 @default.
- W2147552610 hasAuthorship W2147552610A5050637640 @default.
- W2147552610 hasAuthorship W2147552610A5053576191 @default.
- W2147552610 hasAuthorship W2147552610A5064908718 @default.
- W2147552610 hasAuthorship W2147552610A5072121280 @default.
- W2147552610 hasAuthorship W2147552610A5085549140 @default.
- W2147552610 hasBestOaLocation W21475526101 @default.
- W2147552610 hasConcept C105696609 @default.
- W2147552610 hasConcept C120504264 @default.
- W2147552610 hasConcept C190283241 @default.
- W2147552610 hasConcept C199835354 @default.
- W2147552610 hasConcept C2777228722 @default.
- W2147552610 hasConcept C2781252693 @default.
- W2147552610 hasConcept C29537977 @default.
- W2147552610 hasConcept C502942594 @default.
- W2147552610 hasConcept C55493867 @default.
- W2147552610 hasConcept C75217442 @default.
- W2147552610 hasConcept C86803240 @default.
- W2147552610 hasConceptScore W2147552610C105696609 @default.
- W2147552610 hasConceptScore W2147552610C120504264 @default.
- W2147552610 hasConceptScore W2147552610C190283241 @default.
- W2147552610 hasConceptScore W2147552610C199835354 @default.
- W2147552610 hasConceptScore W2147552610C2777228722 @default.
- W2147552610 hasConceptScore W2147552610C2781252693 @default.
- W2147552610 hasConceptScore W2147552610C29537977 @default.
- W2147552610 hasConceptScore W2147552610C502942594 @default.
- W2147552610 hasConceptScore W2147552610C55493867 @default.
- W2147552610 hasConceptScore W2147552610C75217442 @default.
- W2147552610 hasConceptScore W2147552610C86803240 @default.
- W2147552610 hasLocation W21475526101 @default.
- W2147552610 hasLocation W21475526102 @default.
- W2147552610 hasOpenAccess W2147552610 @default.
- W2147552610 hasPrimaryLocation W21475526101 @default.
- W2147552610 hasRelatedWork W2002858229 @default.
- W2147552610 hasRelatedWork W2008314452 @default.
- W2147552610 hasRelatedWork W2025951391 @default.
- W2147552610 hasRelatedWork W2058978042 @default.
- W2147552610 hasRelatedWork W2147552610 @default.
- W2147552610 hasRelatedWork W2359296231 @default.
- W2147552610 hasRelatedWork W2370759520 @default.
- W2147552610 hasRelatedWork W2380195576 @default.
- W2147552610 hasRelatedWork W2549574514 @default.
- W2147552610 hasRelatedWork W2912550910 @default.
- W2147552610 isParatext "false" @default.
- W2147552610 isRetracted "false" @default.
- W2147552610 magId "2147552610" @default.
- W2147552610 workType "article" @default.