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- W2147557017 abstract "18 women (6 healthy women with regular menstrual cycles and 12 women with anovulatory infertility or amenorrhea being treated with clomiphene citrate) were initially studied to evaluate a new method for the determination of SHBG (sex-hormone-binding globulin-binding capacity. The anovulatory group had been suffering from amenorrhea for 1 to 3 years, but none of the women were hirsute or hypothroid. Blood samples were collected on days 7, 14, and 21, of spontaneous cycles; for amenorrheic women, blood samples were collected at the start of the clomiphene treatment and 1 and 2 weeks later. Plasma-SHBG, estradiol, and, plasma progesterone were measured. A significant increase in SHBG from day 7 to day 21 was observed among the spontaneous ovulatory cycles; patients who ovulated in response to clomiphene also exhibited a significant rise (59+ or -7.9) at day 21, while those who did not ovulate in response to clomiphene and in whom there was no increase in plasma-estradiol did not exhibit any change in SHBG. These findings show a significant increase in SHBG during spontaneous and induced ovulatory cycles but not in anovulatory cycles. This binding protein can be used to assess ovulatory function in infertile women, particularly those on clomiphene therapy." @default.
- W2147557017 created "2016-06-24" @default.
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- W2147557017 date "1979-05-01" @default.
- W2147557017 modified "2023-09-27" @default.
- W2147557017 title "SEX-HORMONE-BINDING GLOBULIN: AN ADDITIONAL TEST FOR OVULATORY FUNCTION" @default.
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- W2147557017 doi "https://doi.org/10.1016/s0140-6736(79)91770-7" @default.
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