FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147618577> ?p ?o ?g. }

• W2147618577 endingPage "217" @default.
• W2147618577 startingPage "210" @default.
• W2147618577 abstract "ABSTRACT The two lysis genes cph1 and cpl1 of the Streptococcus pneumoniae bacteriophage Cp-1 coding for holin and lysozyme, respectively, have been cloned and expressed in Escherichia coli . Synthesis of the Cph1 holin resulted in bacterial cell death but not lysis. The cph1 gene was able to complement a lambda S am mutation in the nonsuppressing E. coli HB101 strain to produce phage progeny, suggesting that the holins encoded by both phage genes have analogous functions and that the pneumococcal holin induces a nonspecific lesion in the cytoplasmic membrane. Concomitant expression of both holin and lysin of Cp-1 in E. coli resulted in cell lysis, apparently due to the ability of the Cpl1 lysozyme to hydrolyze the peptidoglycan layer of this bacterium. The functional analysis of the cph1 and cpl1 genes cloned in a pneumococcal mutant with a complete deletion of the lytA gene, which codes for the S. pneumoniae main autolysin, provided the first direct evidence that, in this gram-positive-bacterium system, the Cpl1 endolysin is released to its murein substrate through the activity of the Cph1 holin. Demonstration of holin function was achieved by proving the release of pneumolysin to the periplasmic fraction, which strongly suggested that the holin produces a lesion in the pneumococcal membrane." @default.
• W2147618577 created "2016-06-24" @default.
• W2147618577 creator A5016769904 @default.
• W2147618577 creator A5060687832 @default.
• W2147618577 creator A5079557997 @default.
• W2147618577 date "1998-01-15" @default.
• W2147618577 modified "2023-10-17" @default.
• W2147618577 title "Functional Analysis of the Two-Gene Lysis System of the Pneumococcal Phage Cp-1 in Homologous and Heterologous Host Cells" @default.
• W2147618577 cites W1481181027 @default.
• W2147618577 cites W1561336711 @default.
• W2147618577 cites W1572378007 @default.
• W2147618577 cites W1593746865 @default.
• W2147618577 cites W1665655905 @default.
• W2147618577 cites W1680641743 @default.
• W2147618577 cites W1824120126 @default.
• W2147618577 cites W1852844868 @default.
• W2147618577 cites W1869724171 @default.
• W2147618577 cites W1915845607 @default.
• W2147618577 cites W1949426623 @default.
• W2147618577 cites W1973604889 @default.
• W2147618577 cites W1980683486 @default.
• W2147618577 cites W1995448634 @default.
• W2147618577 cites W2004487933 @default.
• W2147618577 cites W2009066697 @default.
• W2147618577 cites W2014782925 @default.
• W2147618577 cites W2039125923 @default.
• W2147618577 cites W2040591804 @default.
• W2147618577 cites W2044655554 @default.
• W2147618577 cites W2062114477 @default.
• W2147618577 cites W2081753388 @default.
• W2147618577 cites W2090152223 @default.
• W2147618577 cites W2140166862 @default.
• W2147618577 cites W2141106787 @default.
• W2147618577 cites W2152464705 @default.
• W2147618577 cites W2157565587 @default.
• W2147618577 cites W2165751955 @default.
• W2147618577 cites W4231387355 @default.
• W2147618577 doi "https://doi.org/10.1128/jb.180.2.210-217.1998" @default.
• W2147618577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/106873" @default.
• W2147618577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9440507" @default.
• W2147618577 hasPublicationYear "1998" @default.
• W2147618577 type Work @default.
• W2147618577 sameAs 2147618577 @default.
• W2147618577 citedByCount "19" @default.
• W2147618577 countsByYear W21476185772012 @default.
• W2147618577 countsByYear W21476185772013 @default.
• W2147618577 countsByYear W21476185772014 @default.
• W2147618577 countsByYear W21476185772020 @default.
• W2147618577 countsByYear W21476185772021 @default.
• W2147618577 countsByYear W21476185772022 @default.
• W2147618577 crossrefType "journal-article" @default.
• W2147618577 hasAuthorship W2147618577A5016769904 @default.
• W2147618577 hasAuthorship W2147618577A5060687832 @default.
• W2147618577 hasAuthorship W2147618577A5079557997 @default.
• W2147618577 hasBestOaLocation W21476185771 @default.
• W2147618577 hasConcept C104317684 @default.
• W2147618577 hasConcept C153911025 @default.
• W2147618577 hasConcept C159047783 @default.
• W2147618577 hasConcept C182615771 @default.
• W2147618577 hasConcept C201663137 @default.
• W2147618577 hasConcept C22538091 @default.
• W2147618577 hasConcept C2522874641 @default.
• W2147618577 hasConcept C2776088486 @default.
• W2147618577 hasConcept C2776441376 @default.
• W2147618577 hasConcept C2776634448 @default.
• W2147618577 hasConcept C2776809874 @default.
• W2147618577 hasConcept C2781253189 @default.
• W2147618577 hasConcept C501593827 @default.
• W2147618577 hasConcept C54355233 @default.
• W2147618577 hasConcept C547475151 @default.
• W2147618577 hasConcept C62361671 @default.
• W2147618577 hasConcept C86803240 @default.
• W2147618577 hasConcept C89423630 @default.
• W2147618577 hasConceptScore W2147618577C104317684 @default.
• W2147618577 hasConceptScore W2147618577C153911025 @default.
• W2147618577 hasConceptScore W2147618577C159047783 @default.
• W2147618577 hasConceptScore W2147618577C182615771 @default.
• W2147618577 hasConceptScore W2147618577C201663137 @default.
• W2147618577 hasConceptScore W2147618577C22538091 @default.
• W2147618577 hasConceptScore W2147618577C2522874641 @default.
• W2147618577 hasConceptScore W2147618577C2776088486 @default.
• W2147618577 hasConceptScore W2147618577C2776441376 @default.
• W2147618577 hasConceptScore W2147618577C2776634448 @default.
• W2147618577 hasConceptScore W2147618577C2776809874 @default.
• W2147618577 hasConceptScore W2147618577C2781253189 @default.
• W2147618577 hasConceptScore W2147618577C501593827 @default.
• W2147618577 hasConceptScore W2147618577C54355233 @default.
• W2147618577 hasConceptScore W2147618577C547475151 @default.
• W2147618577 hasConceptScore W2147618577C62361671 @default.
• W2147618577 hasConceptScore W2147618577C86803240 @default.
• W2147618577 hasConceptScore W2147618577C89423630 @default.
• W2147618577 hasIssue "2" @default.
• W2147618577 hasLocation W21476185771 @default.
• W2147618577 hasLocation W21476185772 @default.
• W2147618577 hasLocation W21476185773 @default.
• W2147618577 hasLocation W21476185774 @default.
• W2147618577 hasOpenAccess W2147618577 @default.
• W2147618577 hasPrimaryLocation W21476185771 @default.

• next