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- W2147627829 abstract "The plasma membrane of eukaryotic cells is the limit to interact with the environment. This position implies receiving stress signals that affects its components such as phospholipids. Inserted inside these components is coenzyme Q that is a redox compound acting as antioxidant. Coenzyme Q is reduced by diverse dehydrogenase enzymes mainly NADH-cytochrome b(5) reductase and NAD(P)H:quinone reductase 1. Reduced coenzyme Q can prevent lipid peroxidation chain reaction by itself or by reducing other antioxidants such as alpha-tocopherol and ascorbate. The group formed by antioxidants and the enzymes able to reduce coenzyme Q constitutes a plasma membrane redox system that is regulated by conditions that induce oxidative stress. Growth factor removal, ethidium bromide-induced rho degrees cells, and vitamin E deficiency are some of the conditions where both coenzyme Q and its reductases are increased in the plasma membrane. This antioxidant system in the plasma membrane has been observed to participate in the healthy aging induced by calorie restriction. Furthermore, coenzyme Q regulates the release of ceramide from sphingomyelin, which is concentrated in the plasma membrane. This results from the non-competitive inhibition of the neutral sphingomyelinase by coenzyme Q particularly by its reduced form. Coenzyme Q in the plasma membrane is then the center of a complex antioxidant system preventing the accumulation of oxidative damage and regulating the externally initiated ceramide signaling pathway." @default.
- W2147627829 created "2016-06-24" @default.
- W2147627829 creator A5014289292 @default.
- W2147627829 creator A5038923785 @default.
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- W2147627829 date "2007-06-01" @default.
- W2147627829 modified "2023-10-02" @default.
- W2147627829 title "The importance of plasma membrane coenzyme Q in aging and stress responses" @default.
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- W2147627829 cites W1495857073 @default.
- W2147627829 cites W1508304246 @default.
- W2147627829 cites W1511440139 @default.
- W2147627829 cites W1527288304 @default.
- W2147627829 cites W1548744261 @default.
- W2147627829 cites W1570534757 @default.
- W2147627829 cites W1604174475 @default.
- W2147627829 cites W1616682748 @default.
- W2147627829 cites W1725920997 @default.
- W2147627829 cites W172604253 @default.
- W2147627829 cites W1843387896 @default.
- W2147627829 cites W1963953060 @default.
- W2147627829 cites W1968419251 @default.
- W2147627829 cites W1970122049 @default.
- W2147627829 cites W1970156947 @default.
- W2147627829 cites W1970321565 @default.
- W2147627829 cites W1971714188 @default.
- W2147627829 cites W1974684319 @default.
- W2147627829 cites W1975221284 @default.
- W2147627829 cites W1977707442 @default.
- W2147627829 cites W1979328799 @default.
- W2147627829 cites W1983694428 @default.
- W2147627829 cites W1989727003 @default.
- W2147627829 cites W1993504110 @default.
- W2147627829 cites W1993617172 @default.
- W2147627829 cites W1995216829 @default.
- W2147627829 cites W2002922576 @default.
- W2147627829 cites W2003474943 @default.
- W2147627829 cites W2007349182 @default.
- W2147627829 cites W2008237373 @default.
- W2147627829 cites W2009865734 @default.
- W2147627829 cites W2017464721 @default.
- W2147627829 cites W2017729786 @default.
- W2147627829 cites W2020349697 @default.
- W2147627829 cites W2021428997 @default.
- W2147627829 cites W2022381285 @default.
- W2147627829 cites W2026093220 @default.
- W2147627829 cites W2027255959 @default.
- W2147627829 cites W2032421261 @default.
- W2147627829 cites W2036420941 @default.
- W2147627829 cites W2038278880 @default.
- W2147627829 cites W2044809529 @default.
- W2147627829 cites W2048611835 @default.
- W2147627829 cites W2048787555 @default.
- W2147627829 cites W2051963685 @default.
- W2147627829 cites W2052012292 @default.
- W2147627829 cites W2053204073 @default.
- W2147627829 cites W2053745854 @default.
- W2147627829 cites W2058887428 @default.
- W2147627829 cites W2062939746 @default.
- W2147627829 cites W2065436868 @default.
- W2147627829 cites W2074330066 @default.
- W2147627829 cites W2074740541 @default.
- W2147627829 cites W2075226068 @default.
- W2147627829 cites W2075465436 @default.
- W2147627829 cites W2076305935 @default.
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- W2147627829 cites W2089963003 @default.
- W2147627829 cites W2093005591 @default.
- W2147627829 cites W2097811288 @default.
- W2147627829 cites W2099354599 @default.
- W2147627829 cites W2099547258 @default.
- W2147627829 cites W2120458254 @default.
- W2147627829 cites W2125762027 @default.
- W2147627829 cites W2129639464 @default.
- W2147627829 cites W2133615399 @default.
- W2147627829 cites W2136829516 @default.
- W2147627829 cites W2143730031 @default.
- W2147627829 cites W2152390180 @default.
- W2147627829 cites W2165877705 @default.
- W2147627829 cites W2169706900 @default.
- W2147627829 cites W2173108077 @default.
- W2147627829 cites W2303142854 @default.
- W2147627829 cites W2330164218 @default.
- W2147627829 cites W4212775706 @default.
- W2147627829 doi "https://doi.org/10.1016/j.mito.2007.02.010" @default.
- W2147627829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17482527" @default.
- W2147627829 hasPublicationYear "2007" @default.
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