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• W2147647029 endingPage "386" @default.
• W2147647029 startingPage "377" @default.
• W2147647029 abstract "Antimuscarinics are the drugs of choice for the treatment of detrusor overactivity (DO) and overactive bladder (OAB) syndrome. However, the mechanisms for their beneficial effects have not yet been definitely established.Literature available on the pathophysiologic aspects of storage symptoms and of antimuscarinic actions on the bladder was reviewed.Medline was searched for the period ending October 2010 and included studies on human and animal tissues and animal models. Clinical studies exploring mechanisms involved in the effects of antimuscarinics were included. Searches were limited to the English language.Evidence for release of acetylcholine (ACh) from non-neuronal as well as neuronal sources during bladder filling has been demonstrated in isolated animal bladders as well as the human bladder. Urothelially derived ACh, probably via release of adenosine triphosphate, may stimulate afferent activity (afferent noise) from the bladder contributing to OAB and DO. Afferent noise may also be generated by local ACh release within the detrusor muscle. This afferent activity can be inhibited by antimuscarinics at the low concentrations obtained with doses recommended for clinical use in OAB/DO. Within this therapeutic window, antimuscarinics may decrease OAB symptoms and DO without affecting the voiding contraction. Changes in muscarinic receptor functions have been demonstrated with aging and in different disorders associated with OAB/DO.ACh, derived from non-neuronal as well as neuronal sources and during bladder filling, directly or indirectly stimulates afferent activity from the bladder, contributing to OAB and DO. By inhibiting this effect, antimuscarinics may decrease OAB symptoms and DO without affecting the voiding contraction. Even if changes in muscarinic receptor functions may occur with aging and in different disorders associated with OAB/DO, such changes have not been shown convincingly to modify the beneficial effect of antimuscarinics in OAB/DO." @default.
• W2147647029 created "2016-06-24" @default.
• W2147647029 creator A5014135786 @default.
• W2147647029 date "2011-03-01" @default.
• W2147647029 modified "2023-10-18" @default.
• W2147647029 title "Antimuscarinic Mechanisms and the Overactive Detrusor: An Update" @default.
• W2147647029 cites W122380997 @default.
• W2147647029 cites W1555940045 @default.
• W2147647029 cites W1585489386 @default.
• W2147647029 cites W1685542390 @default.
• W2147647029 cites W1831556795 @default.
• W2147647029 cites W1965113248 @default.
• W2147647029 cites W1965313574 @default.
• W2147647029 cites W1969195277 @default.
• W2147647029 cites W1972623889 @default.
• W2147647029 cites W1973777095 @default.
• W2147647029 cites W1974772586 @default.
• W2147647029 cites W1974849697 @default.
• W2147647029 cites W1976074713 @default.
• W2147647029 cites W1977088848 @default.
• W2147647029 cites W1982475468 @default.
• W2147647029 cites W1982985810 @default.
• W2147647029 cites W1986144371 @default.
• W2147647029 cites W1987111921 @default.
• W2147647029 cites W1987355710 @default.
• W2147647029 cites W1988329889 @default.
• W2147647029 cites W1988774053 @default.
• W2147647029 cites W1989637542 @default.
• W2147647029 cites W1991658964 @default.
• W2147647029 cites W1994144996 @default.
• W2147647029 cites W1994231517 @default.
• W2147647029 cites W1997062996 @default.
• W2147647029 cites W1997317772 @default.
• W2147647029 cites W1998385674 @default.
• W2147647029 cites W1999606060 @default.
• W2147647029 cites W2002182591 @default.
• W2147647029 cites W2003196128 @default.
• W2147647029 cites W2007044397 @default.
• W2147647029 cites W2007668739 @default.
• W2147647029 cites W2011197885 @default.
• W2147647029 cites W2012618608 @default.
• W2147647029 cites W2012680765 @default.
• W2147647029 cites W2015656030 @default.
• W2147647029 cites W2015727883 @default.
• W2147647029 cites W2017353450 @default.
• W2147647029 cites W2020235268 @default.
• W2147647029 cites W2020320506 @default.
• W2147647029 cites W2021934052 @default.
• W2147647029 cites W2022805127 @default.
• W2147647029 cites W2024027542 @default.
• W2147647029 cites W2024532328 @default.
• W2147647029 cites W2024694812 @default.
• W2147647029 cites W2025675863 @default.
• W2147647029 cites W2029892337 @default.
• W2147647029 cites W2030700436 @default.
• W2147647029 cites W2031329023 @default.
• W2147647029 cites W2031611689 @default.
• W2147647029 cites W2034113473 @default.
• W2147647029 cites W2039658671 @default.
• W2147647029 cites W2040917440 @default.
• W2147647029 cites W2040987700 @default.
• W2147647029 cites W2041509592 @default.
• W2147647029 cites W2042745063 @default.
• W2147647029 cites W2044846185 @default.
• W2147647029 cites W2047648989 @default.
• W2147647029 cites W2050448556 @default.
• W2147647029 cites W2054936592 @default.
• W2147647029 cites W2062212949 @default.
• W2147647029 cites W2063154432 @default.
• W2147647029 cites W2072658132 @default.
• W2147647029 cites W2074046336 @default.
• W2147647029 cites W2074987260 @default.
• W2147647029 cites W2075219977 @default.
• W2147647029 cites W2078073074 @default.
• W2147647029 cites W2078531740 @default.
• W2147647029 cites W2079785628 @default.
• W2147647029 cites W2080303722 @default.
• W2147647029 cites W2081251120 @default.
• W2147647029 cites W2082446065 @default.
• W2147647029 cites W2083484726 @default.
• W2147647029 cites W2086862896 @default.
• W2147647029 cites W2087647828 @default.
• W2147647029 cites W2087702932 @default.
• W2147647029 cites W2089437227 @default.
• W2147647029 cites W2091743758 @default.
• W2147647029 cites W2101106490 @default.
• W2147647029 cites W2108836444 @default.
• W2147647029 cites W2109675166 @default.
• W2147647029 cites W2111752652 @default.
• W2147647029 cites W2112835658 @default.
• W2147647029 cites W2115644101 @default.
• W2147647029 cites W2127743572 @default.
• W2147647029 cites W2128613789 @default.
• W2147647029 cites W2129881135 @default.
• W2147647029 cites W2134121470 @default.
• W2147647029 cites W2138665941 @default.
• W2147647029 cites W2141728344 @default.
• W2147647029 cites W2143865645 @default.

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