FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147647376> ?p ?o ?g. }

• W2147647376 endingPage "10778" @default.
• W2147647376 startingPage "10769" @default.
• W2147647376 abstract "Previous studies have found that children with multiple exposures to anesthesia at an early age are at increased risk of learning and memory impairment. Sevoflurane is the most commonly used inhalational anesthetic for general anesthesia in children. Multiple exposures to sevoflurane have been shown to induce neuroinflammation, inhibit neurogenesis, and cause subsequent learning and memory impairments in fetal mice. Histone-tail acetylation has been implicated in memory formation. In this study, we employed suberanilohydroxamic acid (SAHA), an inhibitor of histone deacetylases, to treat sevoflurane-induced learning and memory impairments. Six-day-old C57BL/6 mice were exposed to sevoflurane for 2 h daily for 3 days. Morris water maze test performed to evaluate learning and memory impairments and the expression of genes related in to synaptic remodeling/plasticity, or regulated by neuronal activity or the cell cycle were detected by real-time PCR. We found that SAHA attenuated sevoflurane-induced learning and memory impairments in fetal mice. Our findings suggest that SAHA may have potential as a therapeutic agent for preventing or treating the neurotoxicity associated with anesthesia." @default.
• W2147647376 created "2016-06-24" @default.
• W2147647376 creator A5027150132 @default.
• W2147647376 creator A5037160726 @default.
• W2147647376 creator A5042656399 @default.
• W2147647376 creator A5044256474 @default.
• W2147647376 creator A5047105514 @default.
• W2147647376 creator A5065533984 @default.
• W2147647376 creator A5079993740 @default.
• W2147647376 creator A5080282413 @default.
• W2147647376 creator A5084632731 @default.
• W2147647376 date "2014-01-01" @default.
• W2147647376 modified "2023-10-01" @default.
• W2147647376 title "SAHA attenuates sevoflurane-induced learning and memory impairments in fetal mice" @default.
• W2147647376 cites W1964139850 @default.
• W2147647376 cites W1964372470 @default.
• W2147647376 cites W1974400343 @default.
• W2147647376 cites W1989407684 @default.
• W2147647376 cites W2005928381 @default.
• W2147647376 cites W2008918150 @default.
• W2147647376 cites W2025349048 @default.
• W2147647376 cites W2042966900 @default.
• W2147647376 cites W2046244011 @default.
• W2147647376 cites W2046459630 @default.
• W2147647376 cites W2070059007 @default.
• W2147647376 cites W2084031162 @default.
• W2147647376 cites W2092578112 @default.
• W2147647376 cites W2116620228 @default.
• W2147647376 cites W2121845418 @default.
• W2147647376 cites W2130685024 @default.
• W2147647376 cites W2130907138 @default.
• W2147647376 cites W2140594985 @default.
• W2147647376 cites W2151368477 @default.
• W2147647376 cites W2409690306 @default.
• W2147647376 doi "https://doi.org/10.4238/2014.december.18.18" @default.
• W2147647376 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25526197" @default.
• W2147647376 hasPublicationYear "2014" @default.
• W2147647376 type Work @default.
• W2147647376 sameAs 2147647376 @default.
• W2147647376 citedByCount "9" @default.
• W2147647376 countsByYear W21476473762017 @default.
• W2147647376 countsByYear W21476473762019 @default.
• W2147647376 countsByYear W21476473762020 @default.
• W2147647376 countsByYear W21476473762021 @default.
• W2147647376 countsByYear W21476473762023 @default.
• W2147647376 crossrefType "journal-article" @default.
• W2147647376 hasAuthorship W2147647376A5027150132 @default.
• W2147647376 hasAuthorship W2147647376A5037160726 @default.
• W2147647376 hasAuthorship W2147647376A5042656399 @default.
• W2147647376 hasAuthorship W2147647376A5044256474 @default.
• W2147647376 hasAuthorship W2147647376A5047105514 @default.
• W2147647376 hasAuthorship W2147647376A5065533984 @default.
• W2147647376 hasAuthorship W2147647376A5079993740 @default.
• W2147647376 hasAuthorship W2147647376A5080282413 @default.
• W2147647376 hasAuthorship W2147647376A5084632731 @default.
• W2147647376 hasBestOaLocation W21476473761 @default.
• W2147647376 hasConcept C126322002 @default.
• W2147647376 hasConcept C134018914 @default.
• W2147647376 hasConcept C15744967 @default.
• W2147647376 hasConcept C169760540 @default.
• W2147647376 hasConcept C169900460 @default.
• W2147647376 hasConcept C170493617 @default.
• W2147647376 hasConcept C2776914184 @default.
• W2147647376 hasConcept C2778162923 @default.
• W2147647376 hasConcept C2779491297 @default.
• W2147647376 hasConcept C2781161787 @default.
• W2147647376 hasConcept C2781453256 @default.
• W2147647376 hasConcept C29730261 @default.
• W2147647376 hasConcept C3018842126 @default.
• W2147647376 hasConcept C42219234 @default.
• W2147647376 hasConcept C44752575 @default.
• W2147647376 hasConcept C4746552 @default.
• W2147647376 hasConcept C71924100 @default.
• W2147647376 hasConcept C87753298 @default.
• W2147647376 hasConcept C98229152 @default.
• W2147647376 hasConcept C98274493 @default.
• W2147647376 hasConceptScore W2147647376C126322002 @default.
• W2147647376 hasConceptScore W2147647376C134018914 @default.
• W2147647376 hasConceptScore W2147647376C15744967 @default.
• W2147647376 hasConceptScore W2147647376C169760540 @default.
• W2147647376 hasConceptScore W2147647376C169900460 @default.
• W2147647376 hasConceptScore W2147647376C170493617 @default.
• W2147647376 hasConceptScore W2147647376C2776914184 @default.
• W2147647376 hasConceptScore W2147647376C2778162923 @default.
• W2147647376 hasConceptScore W2147647376C2779491297 @default.
• W2147647376 hasConceptScore W2147647376C2781161787 @default.
• W2147647376 hasConceptScore W2147647376C2781453256 @default.
• W2147647376 hasConceptScore W2147647376C29730261 @default.
• W2147647376 hasConceptScore W2147647376C3018842126 @default.
• W2147647376 hasConceptScore W2147647376C42219234 @default.
• W2147647376 hasConceptScore W2147647376C44752575 @default.
• W2147647376 hasConceptScore W2147647376C4746552 @default.
• W2147647376 hasConceptScore W2147647376C71924100 @default.
• W2147647376 hasConceptScore W2147647376C87753298 @default.
• W2147647376 hasConceptScore W2147647376C98229152 @default.
• W2147647376 hasConceptScore W2147647376C98274493 @default.
• W2147647376 hasIssue "4" @default.
• W2147647376 hasLocation W21476473761 @default.

• next