FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147651272> ?p ?o ?g. }

• W2147651272 endingPage "4111" @default.
• W2147651272 startingPage "4105" @default.
• W2147651272 abstract "We previously reported a 660-bp mouse mammary tumor virus (MMTV)-like env gene sequence in approximately 38% of human breast cancer DNA, but not in normal breasts or other tumors. This MMTV-like env gene sequence was expressed in 66% of the env gene-positive human breast cancers. An entire proviral structure was identified in human breast cancer DNA with high homology to MMTV and low homology to known human endogenous retrovirus. MMTV-like long terminal repeat (LTR) sequences were also detected in 41.5% of human breast cancers. They contain hormone-responsive elements, TEF-1 family elements, and the open reading frame for the superantigen (SAg). We have now amplified and sequenced MMTV-like sag sequences from 10 human breast cancers, and we found that they are highly homologous to those of MMTV. However, deletions and insertions at the COOH-terminal of sag were observed. The immune function of the human MMTV-like LTR SAg was also investigated. The sag gene was cloned and expressed in a human B-cell line (Ramos). T-cell proliferation and cytokine releasing assays were performed after cocultivation of T cells with irradiated Ramos SAg-expressing cells. The results indicate that expression of the human SAg stimulates T-cell activation in vitro, as the mouse SAg does. Because the T-cell responses in vitro are considered similar to those in vivo, these results suggest that the human LTR SAg might also play a role in human breast carcinogenesis." @default.
• W2147651272 created "2016-06-24" @default.
• W2147651272 creator A5020521518 @default.
• W2147651272 creator A5023903352 @default.
• W2147651272 creator A5030924064 @default.
• W2147651272 creator A5033632697 @default.
• W2147651272 creator A5038805449 @default.
• W2147651272 creator A5072965952 @default.
• W2147651272 creator A5078029006 @default.
• W2147651272 date "2004-06-15" @default.
• W2147651272 modified "2023-09-24" @default.
• W2147651272 title "A Mouse Mammary Tumor Virus-Like Long Terminal Repeat Superantigen in Human Breast Cancer" @default.
• W2147651272 cites W1501785654 @default.
• W2147651272 cites W1563976062 @default.
• W2147651272 cites W1972089488 @default.
• W2147651272 cites W1977656078 @default.
• W2147651272 cites W1984632638 @default.
• W2147651272 cites W1990283298 @default.
• W2147651272 cites W1995270566 @default.
• W2147651272 cites W2044119777 @default.
• W2147651272 cites W2047188033 @default.
• W2147651272 cites W2064143662 @default.
• W2147651272 cites W2071428576 @default.
• W2147651272 cites W2113163719 @default.
• W2147651272 cites W2334073931 @default.
• W2147651272 cites W4232797909 @default.
• W2147651272 doi "https://doi.org/10.1158/0008-5472.can-03-3880" @default.
• W2147651272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15205319" @default.
• W2147651272 hasPublicationYear "2004" @default.
• W2147651272 type Work @default.
• W2147651272 sameAs 2147651272 @default.
• W2147651272 citedByCount "58" @default.
• W2147651272 countsByYear W21476512722012 @default.
• W2147651272 countsByYear W21476512722013 @default.
• W2147651272 countsByYear W21476512722014 @default.
• W2147651272 countsByYear W21476512722015 @default.
• W2147651272 countsByYear W21476512722016 @default.
• W2147651272 countsByYear W21476512722018 @default.
• W2147651272 countsByYear W21476512722019 @default.
• W2147651272 countsByYear W21476512722020 @default.
• W2147651272 countsByYear W21476512722022 @default.
• W2147651272 countsByYear W21476512722023 @default.
• W2147651272 crossrefType "journal-article" @default.
• W2147651272 hasAuthorship W2147651272A5020521518 @default.
• W2147651272 hasAuthorship W2147651272A5023903352 @default.
• W2147651272 hasAuthorship W2147651272A5030924064 @default.
• W2147651272 hasAuthorship W2147651272A5033632697 @default.
• W2147651272 hasAuthorship W2147651272A5038805449 @default.
• W2147651272 hasAuthorship W2147651272A5072965952 @default.
• W2147651272 hasAuthorship W2147651272A5078029006 @default.
• W2147651272 hasConcept C104317684 @default.
• W2147651272 hasConcept C150194340 @default.
• W2147651272 hasConcept C153911025 @default.
• W2147651272 hasConcept C159047783 @default.
• W2147651272 hasConcept C199491388 @default.
• W2147651272 hasConcept C203014093 @default.
• W2147651272 hasConcept C2776090121 @default.
• W2147651272 hasConcept C2778431562 @default.
• W2147651272 hasConcept C2779777497 @default.
• W2147651272 hasConcept C36333154 @default.
• W2147651272 hasConcept C502942594 @default.
• W2147651272 hasConcept C54355233 @default.
• W2147651272 hasConcept C555283112 @default.
• W2147651272 hasConcept C86803240 @default.
• W2147651272 hasConcept C8891405 @default.
• W2147651272 hasConceptScore W2147651272C104317684 @default.
• W2147651272 hasConceptScore W2147651272C150194340 @default.
• W2147651272 hasConceptScore W2147651272C153911025 @default.
• W2147651272 hasConceptScore W2147651272C159047783 @default.
• W2147651272 hasConceptScore W2147651272C199491388 @default.
• W2147651272 hasConceptScore W2147651272C203014093 @default.
• W2147651272 hasConceptScore W2147651272C2776090121 @default.
• W2147651272 hasConceptScore W2147651272C2778431562 @default.
• W2147651272 hasConceptScore W2147651272C2779777497 @default.
• W2147651272 hasConceptScore W2147651272C36333154 @default.
• W2147651272 hasConceptScore W2147651272C502942594 @default.
• W2147651272 hasConceptScore W2147651272C54355233 @default.
• W2147651272 hasConceptScore W2147651272C555283112 @default.
• W2147651272 hasConceptScore W2147651272C86803240 @default.
• W2147651272 hasConceptScore W2147651272C8891405 @default.
• W2147651272 hasIssue "12" @default.
• W2147651272 hasLocation W21476512721 @default.
• W2147651272 hasLocation W21476512722 @default.
• W2147651272 hasOpenAccess W2147651272 @default.
• W2147651272 hasPrimaryLocation W21476512721 @default.
• W2147651272 hasRelatedWork W1960355296 @default.
• W2147651272 hasRelatedWork W1976481318 @default.
• W2147651272 hasRelatedWork W2022748435 @default.
• W2147651272 hasRelatedWork W2029871904 @default.
• W2147651272 hasRelatedWork W2099619063 @default.
• W2147651272 hasRelatedWork W2146148599 @default.
• W2147651272 hasRelatedWork W2147651272 @default.
• W2147651272 hasRelatedWork W2299493141 @default.
• W2147651272 hasRelatedWork W2443209292 @default.
• W2147651272 hasRelatedWork W3158030959 @default.
• W2147651272 hasVolume "64" @default.
• W2147651272 isParatext "false" @default.
• W2147651272 isRetracted "false" @default.

• next