Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147652807> ?p ?o ?g. }
- W2147652807 endingPage "870" @default.
- W2147652807 startingPage "864" @default.
- W2147652807 abstract "The distinction between bactericidal and bacteriostatic agents appears to be clear according to the in vitro definition, but this only applies under strict laboratory conditions and is inconsistent for a particular agent against all bacteria. The distinction is more arbitrary when agents are categorized in clinical situations. The supposed superiority of bactericidal agents over bacteriostatic agents is of little relevance when treating the vast majority of infections with gram-positive bacteria, particularly in patients with uncomplicated infections and noncompromised immune systems. Bacteriostatic agents (e.g., chloramphenicol, clindamycin, and linezolid) have been effectively used for treatment of endocarditis, meningitis, and osteomyelitis--indications that are often considered to require bactericidal activity. Although bacteriostatic/bactericidal data may provide valuable information on the potential action of antibacterial agents in vitro, it is necessary to combine this information with pharmacokinetic and pharmacodynamic data to provide more meaningful prediction of efficacy in vivo. The ultimate guide to treatment of any infection must be clinical outcome." @default.
- W2147652807 created "2016-06-24" @default.
- W2147652807 creator A5057870795 @default.
- W2147652807 creator A5058753721 @default.
- W2147652807 date "2004-03-15" @default.
- W2147652807 modified "2023-10-10" @default.
- W2147652807 title "Clinical Relevance of Bacteriostatic versus Bactericidal Mechanisms of Action in the Treatment of Gram‐Positive Bacterial Infections" @default.
- W2147652807 cites W11063304 @default.
- W2147652807 cites W1568339559 @default.
- W2147652807 cites W1583368956 @default.
- W2147652807 cites W1669792331 @default.
- W2147652807 cites W1855642336 @default.
- W2147652807 cites W1904634031 @default.
- W2147652807 cites W1964311102 @default.
- W2147652807 cites W1965733322 @default.
- W2147652807 cites W1966844148 @default.
- W2147652807 cites W1975334302 @default.
- W2147652807 cites W1979932265 @default.
- W2147652807 cites W1982259692 @default.
- W2147652807 cites W1985432986 @default.
- W2147652807 cites W1986348547 @default.
- W2147652807 cites W1991145376 @default.
- W2147652807 cites W1993299849 @default.
- W2147652807 cites W1995821982 @default.
- W2147652807 cites W2001679011 @default.
- W2147652807 cites W2001963672 @default.
- W2147652807 cites W2003635939 @default.
- W2147652807 cites W2004478686 @default.
- W2147652807 cites W2005683797 @default.
- W2147652807 cites W2006247930 @default.
- W2147652807 cites W2006832398 @default.
- W2147652807 cites W2016449182 @default.
- W2147652807 cites W2026176496 @default.
- W2147652807 cites W2026770760 @default.
- W2147652807 cites W2026814850 @default.
- W2147652807 cites W2032393049 @default.
- W2147652807 cites W2032893012 @default.
- W2147652807 cites W2035281728 @default.
- W2147652807 cites W2038590527 @default.
- W2147652807 cites W2039743226 @default.
- W2147652807 cites W2048993021 @default.
- W2147652807 cites W2049862118 @default.
- W2147652807 cites W2053115956 @default.
- W2147652807 cites W2055948862 @default.
- W2147652807 cites W2062274791 @default.
- W2147652807 cites W2062958813 @default.
- W2147652807 cites W2070567253 @default.
- W2147652807 cites W2074158188 @default.
- W2147652807 cites W2076387592 @default.
- W2147652807 cites W2076602642 @default.
- W2147652807 cites W2076828405 @default.
- W2147652807 cites W2078072577 @default.
- W2147652807 cites W2078883013 @default.
- W2147652807 cites W2081245636 @default.
- W2147652807 cites W2085293377 @default.
- W2147652807 cites W2085685488 @default.
- W2147652807 cites W2090635877 @default.
- W2147652807 cites W2094757636 @default.
- W2147652807 cites W2096465388 @default.
- W2147652807 cites W2103176803 @default.
- W2147652807 cites W2105872313 @default.
- W2147652807 cites W2106927934 @default.
- W2147652807 cites W2111654440 @default.
- W2147652807 cites W2116287639 @default.
- W2147652807 cites W2119843376 @default.
- W2147652807 cites W2120404655 @default.
- W2147652807 cites W2126874955 @default.
- W2147652807 cites W2130946094 @default.
- W2147652807 cites W2133619691 @default.
- W2147652807 cites W2136761329 @default.
- W2147652807 cites W2137275237 @default.
- W2147652807 cites W2140777443 @default.
- W2147652807 cites W2142845647 @default.
- W2147652807 cites W2151859311 @default.
- W2147652807 cites W2154148218 @default.
- W2147652807 cites W2155383806 @default.
- W2147652807 cites W2163120046 @default.
- W2147652807 cites W2169457750 @default.
- W2147652807 cites W2169745236 @default.
- W2147652807 cites W2171658721 @default.
- W2147652807 cites W2171680926 @default.
- W2147652807 cites W2171732900 @default.
- W2147652807 cites W2313974108 @default.
- W2147652807 cites W2315951794 @default.
- W2147652807 cites W2318717670 @default.
- W2147652807 cites W2415951183 @default.
- W2147652807 cites W2417563549 @default.
- W2147652807 cites W2498566111 @default.
- W2147652807 cites W2752539345 @default.
- W2147652807 cites W3022798003 @default.
- W2147652807 cites W4242345260 @default.
- W2147652807 cites W4252426038 @default.
- W2147652807 cites W4300247125 @default.
- W2147652807 cites W4302798313 @default.
- W2147652807 cites W4376096976 @default.
- W2147652807 cites W4384465895 @default.
- W2147652807 cites W8220752 @default.
- W2147652807 doi "https://doi.org/10.1086/381972" @default.