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• W2147666645 abstract "Controlling the spread of morphogens is crucial for pattern formation during development. In the Drosophila wing disc, Wingless secreted at the dorsal-ventral compartment boundary forms a concentration gradient in receiving tissue, where it activates short- and long-range target genes. The glypican Dally-like promotes Wingless spreading by unknown mechanisms, while Dynamin-dependent endocytosis is thought to restrict Wingless spread. We have utilized short-term expression of dominant negative Rab proteins to examine the polarity of endocytic trafficking of Wingless and its receptors and to determine the relative contributions of endocytosis, degradation and recycling to the establishment of the Wingless gradient. Our results show that Wingless is internalized via two spatially distinct routes: one on the apical, and one on the basal, side of the disc. Both restrict the spread of Wingless, with little contribution from subsequent degradation or recycling. As previously shown for Frizzled receptors, depleting Arrow does not prevent Wingless from entering endosomes. We find that both Frizzled and Arrow are internalized mainly from the apical membrane. Thus, the basal Wingless internalization route must be independent of these proteins. We find that Dally-like is not required for Wingless spread when endocytosis is blocked, and propose that Dally-like promotes the spread of Wingless by directing it to lateral membranes, where its endocytosis is less efficient. Thus, subcellular localization of Wingless along the apical-basal axis of receiving cells may be instrumental in shaping the Wingless gradient." @default.
• W2147666645 created "2016-06-24" @default.
• W2147666645 creator A5013723586 @default.
• W2147666645 creator A5022938816 @default.
• W2147666645 creator A5026069642 @default.
• W2147666645 date "2006-01-15" @default.
• W2147666645 modified "2023-10-13" @default.
• W2147666645 title "The endocytic pathway and formation of the Wingless morphogen gradient" @default.
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• W2147666645 doi "https://doi.org/10.1242/dev.02197" @default.
• W2147666645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16354714" @default.
• W2147666645 hasPublicationYear "2006" @default.
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