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- W2147666797 abstract "Ingestion of placenta or amniotic fluid produces a dramatic enhancement of centrally mediated opioid antinociception in the rat. The present experiments investigated the role of each opioid receptor type (μ, δ, κ) in the antinociception-modulating effects of Placental Opioid-Enhancing Factor (POEF—presumably the active substance). Antinociception was measured on a 52 °C hotplate in adult, female rats after they ingested placenta or control substance (1.0 g) and after they received an intracerebroventricular injection of a δ-specific ([d-Pen2,d-Pen5]enkephalin (DPDPE); 0, 30, 50, 62, or 70 nmol), μ-specific ([d-Ala2,N-MePhe4,Gly5-ol]enkephalin (DAMGO); 0, 0.21, 0.29, or 0.39 nmol), or κ-specific (U-62066; spiradoline; 0, 100, 150, or 200 nmol) opioid receptor agonist. The results showed that ingestion of placenta potentiated δ- and κ-opioid antinociception, but attenuated μ-opioid antinociception. This finding of POEF action as both opioid receptor-specific and complex provides an important basis for understanding the intrinsic pain-suppression mechanisms that are activated during parturition and modified by placentophagia, and important information for the possible use of POEF as an adjunct to opioids in pain management." @default.
- W2147666797 created "2016-06-24" @default.
- W2147666797 creator A5005316139 @default.
- W2147666797 creator A5081168778 @default.
- W2147666797 date "2004-07-01" @default.
- W2147666797 modified "2023-09-23" @default.
- W2147666797 title "Placenta ingestion by rats enhances δ- and κ-opioid antinociception, but suppresses μ-opioid antinociception" @default.
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- W2147666797 doi "https://doi.org/10.1016/j.brainres.2004.04.006" @default.
- W2147666797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15212988" @default.
- W2147666797 hasPublicationYear "2004" @default.
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