FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147697293> ?p ?o ?g. }

• W2147697293 endingPage "5841" @default.
• W2147697293 startingPage "5833" @default.
• W2147697293 abstract "Previous studies using feline immunodeficiency virus (FIV) molecular clones lacking the putative transactivator gene (ORF-A/2) failed to address the issue of thymus pathogenesis or investigate the levels of viral replication in separate lymphoid compartments (Y. Inoshima, et al., J. Virol. 70:8518-8526, 1996; E. E. Sparger, et al., Virology 205:546-553, 1994). Using a highly pathogenic molecular clone of FIV, JSY3, and an ORF-A/2-deficient mutant, JSY3DeltaORF-A/2, we compared viral replication and the extent of thymic dysfunction as measured by the formation of lymphoid follicles and alteration of the thymocyte subsets. Viral replication was reduced in JSY3DeltaORF-A/2-infected cats as measured by lymphocyte coculture, immunohistochemistry, and quantitative PCR. Cell-associated viral load measured by lymphocyte coculture varied in a tissue-dependent manner with replication highest in lymphocytes isolated from the thymus, lower in those from the peripheral blood, and lowest in those from lymph node. Thymic proviral load and the number of viral p24 Gag-positive cells within the thymus detected by immunohistochemistry were also reduced. In addition, the onset of a reduced peripheral blood CD4/CD8 ratio was delayed in JSY3DeltaORF-A/2-infected cats. The formation and extent of thymic lymphoid follicular hyperplasia were similar in JSY3 and JSY3DeltaORF-A/2-infected cats as measured by anticytokeratin immunohistochemistry and flow cytometry for percent pan T-negative, immunoglobulin G-positive cells within the thymus. In contrast, comparison of thymocyte subpopulations demonstrated a reduced expansion of single-positive CD4(-) CD8(+) thymocytes in JSY3DeltaORF-A/2-infected cats. Level of viral replication, therefore, may not correlate with the formation of thymic lymphoid follicles but may correlate with the expansion of the single-positive CD4(-) CD8(+) thymocyte subpopulation." @default.
• W2147697293 created "2016-06-24" @default.
• W2147697293 creator A5011514795 @default.
• W2147697293 creator A5040601031 @default.
• W2147697293 creator A5064633007 @default.
• W2147697293 creator A5072159277 @default.
• W2147697293 date "2001-07-01" @default.
• W2147697293 modified "2023-09-26" @default.
• W2147697293 title "Thymic Lesions in Cats Infected with a Pathogenic Molecular Clone or an ORF-A/2 -Deficient Molecular Clone of Feline Immunodeficiency Virus" @default.
• W2147697293 cites W116619909 @default.
• W2147697293 cites W1481555237 @default.
• W2147697293 cites W1491724808 @default.
• W2147697293 cites W1504041593 @default.
• W2147697293 cites W1513063835 @default.
• W2147697293 cites W1574327793 @default.
• W2147697293 cites W1612914901 @default.
• W2147697293 cites W1683411584 @default.
• W2147697293 cites W1938105249 @default.
• W2147697293 cites W1943757146 @default.
• W2147697293 cites W1967768323 @default.
• W2147697293 cites W1976757942 @default.
• W2147697293 cites W1993119950 @default.
• W2147697293 cites W2013902329 @default.
• W2147697293 cites W2017794292 @default.
• W2147697293 cites W2019885900 @default.
• W2147697293 cites W2023391907 @default.
• W2147697293 cites W2023865581 @default.
• W2147697293 cites W2025091872 @default.
• W2147697293 cites W2026338162 @default.
• W2147697293 cites W2032463650 @default.
• W2147697293 cites W2038797788 @default.
• W2147697293 cites W2042784056 @default.
• W2147697293 cites W2049049471 @default.
• W2147697293 cites W2052247149 @default.
• W2147697293 cites W2086459306 @default.
• W2147697293 cites W2096978914 @default.
• W2147697293 cites W2104608140 @default.
• W2147697293 cites W2108236735 @default.
• W2147697293 cites W2111498525 @default.
• W2147697293 cites W2113879190 @default.
• W2147697293 cites W2142837083 @default.
• W2147697293 cites W2144567740 @default.
• W2147697293 cites W2315236452 @default.
• W2147697293 cites W2315428660 @default.
• W2147697293 cites W2467424316 @default.
• W2147697293 cites W2412131378 @default.
• W2147697293 doi "https://doi.org/10.1128/jvi.75.13.5833-5841.2001" @default.
• W2147697293 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/114298" @default.
• W2147697293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11390584" @default.
• W2147697293 hasPublicationYear "2001" @default.
• W2147697293 type Work @default.
• W2147697293 sameAs 2147697293 @default.
• W2147697293 citedByCount "8" @default.
• W2147697293 crossrefType "journal-article" @default.
• W2147697293 hasAuthorship W2147697293A5011514795 @default.
• W2147697293 hasAuthorship W2147697293A5040601031 @default.
• W2147697293 hasAuthorship W2147697293A5064633007 @default.
• W2147697293 hasAuthorship W2147697293A5072159277 @default.
• W2147697293 hasBestOaLocation W21476972931 @default.
• W2147697293 hasConcept C104317684 @default.
• W2147697293 hasConcept C140704245 @default.
• W2147697293 hasConcept C142462285 @default.
• W2147697293 hasConcept C153911025 @default.
• W2147697293 hasConcept C159047783 @default.
• W2147697293 hasConcept C167672396 @default.
• W2147697293 hasConcept C181152851 @default.
• W2147697293 hasConcept C203014093 @default.
• W2147697293 hasConcept C2522874641 @default.
• W2147697293 hasConcept C2777841672 @default.
• W2147697293 hasConcept C2778954852 @default.
• W2147697293 hasConcept C2779690655 @default.
• W2147697293 hasConcept C2780727368 @default.
• W2147697293 hasConcept C55493867 @default.
• W2147697293 hasConcept C81089528 @default.
• W2147697293 hasConcept C86803240 @default.
• W2147697293 hasConcept C8891405 @default.
• W2147697293 hasConceptScore W2147697293C104317684 @default.
• W2147697293 hasConceptScore W2147697293C140704245 @default.
• W2147697293 hasConceptScore W2147697293C142462285 @default.
• W2147697293 hasConceptScore W2147697293C153911025 @default.
• W2147697293 hasConceptScore W2147697293C159047783 @default.
• W2147697293 hasConceptScore W2147697293C167672396 @default.
• W2147697293 hasConceptScore W2147697293C181152851 @default.
• W2147697293 hasConceptScore W2147697293C203014093 @default.
• W2147697293 hasConceptScore W2147697293C2522874641 @default.
• W2147697293 hasConceptScore W2147697293C2777841672 @default.
• W2147697293 hasConceptScore W2147697293C2778954852 @default.
• W2147697293 hasConceptScore W2147697293C2779690655 @default.
• W2147697293 hasConceptScore W2147697293C2780727368 @default.
• W2147697293 hasConceptScore W2147697293C55493867 @default.
• W2147697293 hasConceptScore W2147697293C81089528 @default.
• W2147697293 hasConceptScore W2147697293C86803240 @default.
• W2147697293 hasConceptScore W2147697293C8891405 @default.
• W2147697293 hasIssue "13" @default.
• W2147697293 hasLocation W21476972931 @default.
• W2147697293 hasLocation W21476972932 @default.
• W2147697293 hasLocation W21476972933 @default.
• W2147697293 hasLocation W21476972934 @default.

• next