FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147702009> ?p ?o ?g. }

• W2147702009 endingPage "461" @default.
• W2147702009 startingPage "451" @default.
• W2147702009 abstract "This study examines B-cell immunoglobulin (Ig) class-switching events in the context of parasite antigen-specific Th-cell responses in experimental African trypanosomiasis. Inbred mice were infected with Trypanosoma brucei rhodesiense, and the coordinate stimulation of Th-cell cytokine responses and B-cell responses to the trypanosome variant surface glycoprotein (VSG) was measured. The cytokines produced by T cells in response to VSG, at both the transcript and protein levels, were gamma interferon and interleukin-2 (IL-2) but not IL-4 or IL-5. Isotype profiles of antibodies specific for VSG showed that IgG1, IgG2a, and IgG3 switch responses predominated; no VSG-specific IgE responses were detected. To determine whether cryptic IL-4 responses played a role in promoting the unexpected IgG1 switch response, IL-4 knockout mice were infected; the cytokine responses and Ig isotype profiles of IL-4 knockout mice were identical to those of the wild-type control mice except for dramatically reduced IgG1 levels in response to VSG. Thus, these results revealed an IL-4-dependent component of the VSG-driven B-cell Cmu-to-Cgamma1 switch. We speculate that an IL-4 response is mediated primarily by cells other than T lymphocytes since IL-4-secreting but parasite antigen-unresponsive, background cells were detected in all infected mice and since infected nude mice also displayed a detectable IgG1 switch response. Overall, our results suggest that B-cell clonal stimulation, maturation, and Ig class switching in African trypanosomiasis may be partially regulated by unusual mechanisms that do not include antigen-specific Th1 or Th2 cells." @default.
• W2147702009 created "2016-06-24" @default.
• W2147702009 creator A5040986423 @default.
• W2147702009 creator A5053062539 @default.
• W2147702009 creator A5069297060 @default.
• W2147702009 creator A5070193623 @default.
• W2147702009 date "1998-02-01" @default.
• W2147702009 modified "2023-10-14" @default.
• W2147702009 title "Interleukin-4-Dependent Immunoglobulin G1 Isotype Switch in the Presence of a Polarized Antigen-Specific Th1-Cell Response to the Trypanosome Variant Surface Glycoprotein" @default.
• W2147702009 cites W1481611082 @default.
• W2147702009 cites W1487831618 @default.
• W2147702009 cites W1503226380 @default.
• W2147702009 cites W1505891908 @default.
• W2147702009 cites W1506897962 @default.
• W2147702009 cites W1526379640 @default.
• W2147702009 cites W1539460627 @default.
• W2147702009 cites W1539498191 @default.
• W2147702009 cites W1543892782 @default.
• W2147702009 cites W1572644668 @default.
• W2147702009 cites W1579405851 @default.
• W2147702009 cites W1588182412 @default.
• W2147702009 cites W1596243988 @default.
• W2147702009 cites W1606369440 @default.
• W2147702009 cites W176718053 @default.
• W2147702009 cites W1769351001 @default.
• W2147702009 cites W1800664456 @default.
• W2147702009 cites W1830561633 @default.
• W2147702009 cites W1835411232 @default.
• W2147702009 cites W1901963735 @default.
• W2147702009 cites W1903914623 @default.
• W2147702009 cites W1920248919 @default.
• W2147702009 cites W1941860760 @default.
• W2147702009 cites W1958940526 @default.
• W2147702009 cites W1974016096 @default.
• W2147702009 cites W1978321728 @default.
• W2147702009 cites W1988422289 @default.
• W2147702009 cites W1991805383 @default.
• W2147702009 cites W1992760440 @default.
• W2147702009 cites W1994211974 @default.
• W2147702009 cites W2007569317 @default.
• W2147702009 cites W2012428595 @default.
• W2147702009 cites W2012648344 @default.
• W2147702009 cites W2018802806 @default.
• W2147702009 cites W2022818789 @default.
• W2147702009 cites W2024158949 @default.
• W2147702009 cites W2025706771 @default.
• W2147702009 cites W2031006065 @default.
• W2147702009 cites W2041647537 @default.
• W2147702009 cites W2047816245 @default.
• W2147702009 cites W2056616704 @default.
• W2147702009 cites W2058305440 @default.
• W2147702009 cites W2061325467 @default.
• W2147702009 cites W2063950143 @default.
• W2147702009 cites W2068616722 @default.
• W2147702009 cites W2069412263 @default.
• W2147702009 cites W2073023385 @default.
• W2147702009 cites W2073158216 @default.
• W2147702009 cites W2083549635 @default.
• W2147702009 cites W2091215627 @default.
• W2147702009 cites W2094040175 @default.
• W2147702009 cites W2097439203 @default.
• W2147702009 cites W2107008702 @default.
• W2147702009 cites W2111344966 @default.
• W2147702009 cites W2125633725 @default.
• W2147702009 cites W2127081185 @default.
• W2147702009 cites W2134443084 @default.
• W2147702009 cites W2138068883 @default.
• W2147702009 cites W2143381397 @default.
• W2147702009 cites W2144664976 @default.
• W2147702009 cites W2151820278 @default.
• W2147702009 cites W2160926928 @default.
• W2147702009 cites W2164412635 @default.
• W2147702009 cites W2176085886 @default.
• W2147702009 cites W2177385981 @default.
• W2147702009 cites W2268687328 @default.
• W2147702009 cites W4238030897 @default.
• W2147702009 cites W4313313429 @default.
• W2147702009 cites W63754614 @default.
• W2147702009 cites W67995918 @default.
• W2147702009 doi "https://doi.org/10.1128/iai.66.2.451-461.1998" @default.
• W2147702009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/107927" @default.
• W2147702009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9453595" @default.
• W2147702009 hasPublicationYear "1998" @default.
• W2147702009 type Work @default.
• W2147702009 sameAs 2147702009 @default.
• W2147702009 citedByCount "59" @default.
• W2147702009 countsByYear W21477020092012 @default.
• W2147702009 countsByYear W21477020092013 @default.
• W2147702009 countsByYear W21477020092014 @default.
• W2147702009 countsByYear W21477020092015 @default.
• W2147702009 countsByYear W21477020092016 @default.
• W2147702009 countsByYear W21477020092017 @default.
• W2147702009 countsByYear W21477020092018 @default.
• W2147702009 countsByYear W21477020092019 @default.
• W2147702009 countsByYear W21477020092020 @default.
• W2147702009 countsByYear W21477020092021 @default.
• W2147702009 countsByYear W21477020092023 @default.
• W2147702009 crossrefType "journal-article" @default.

• next