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- W2147702939 abstract "Mast cells can play detrimental roles in the pathophysiology and mortality observed in anaphylaxis and other Th2-dominated allergic diseases. In contrast, these cells contribute to protective host defense mechanisms against parasitic worm infections. After IgE/Ag activation, mast cells can produce multiple cytokines that may enhance allergic inflammations, while a similar panel of Th2-related cytokines may support immunological strategies against parasites. Here we report that in primary mouse bone marrow-derived mast cells activated by ionomycin or IgE/Ag, the proinflammatory mediator IL-1 (alpha or beta) up-regulated production of IL-3, IL-5, IL-6, and IL-9 as well as TNF, i.e., cytokines implicated in many inflammatory processes including those associated with allergies and helminthic infections. IL-1 did not induce significant cytokine release in the absence of ionomycin or IgE/Ag, suggesting that Ca-dependent signaling was required. IL-1-mediated enhancement of cytokine expression was confirmed at the mRNA level by Northern blot and/or RT-PCR analysis. Our study reveals a role for IL-1 in the up-regulation of multiple mast cell-derived cytokines. Moreover, we identify mast cells as a novel source of IL-9. These results are of particular importance in the light of recent reports that strongly support a central role of IL-9 in allergic lung inflammation and in host defense against worm infections." @default.
- W2147702939 created "2016-06-24" @default.
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- W2147702939 date "2000-06-01" @default.
- W2147702939 modified "2023-10-01" @default.
- W2147702939 title "In Activated Mast Cells, IL-1 Up-Regulates the Production of Several Th2-Related Cytokines Including IL-9" @default.
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- W2147702939 cites W1515994079 @default.
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- W2147702939 cites W1532660854 @default.
- W2147702939 cites W1553420527 @default.
- W2147702939 cites W1572105446 @default.
- W2147702939 cites W1582649025 @default.
- W2147702939 cites W1596750378 @default.
- W2147702939 cites W1655248452 @default.
- W2147702939 cites W1655974196 @default.
- W2147702939 cites W1657207959 @default.
- W2147702939 cites W1795089629 @default.
- W2147702939 cites W1838555675 @default.
- W2147702939 cites W1853022482 @default.
- W2147702939 cites W1870393463 @default.
- W2147702939 cites W1904430846 @default.
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- W2147702939 cites W1943450362 @default.
- W2147702939 cites W1949085245 @default.
- W2147702939 cites W1953798395 @default.
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- W2147702939 cites W1997257161 @default.
- W2147702939 cites W1998783767 @default.
- W2147702939 cites W2017014849 @default.
- W2147702939 cites W2028395097 @default.
- W2147702939 cites W2034609926 @default.
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- W2147702939 cites W2037899271 @default.
- W2147702939 cites W2046302976 @default.
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- W2147702939 cites W2061092989 @default.
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- W2147702939 cites W2069808501 @default.
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- W2147702939 cites W2124171263 @default.
- W2147702939 cites W2131012769 @default.
- W2147702939 cites W2133041797 @default.
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- W2147702939 doi "https://doi.org/10.4049/jimmunol.164.11.5556" @default.
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