FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147722966> ?p ?o ?g. }

• W2147722966 endingPage "1295" @default.
• W2147722966 startingPage "1281" @default.
• W2147722966 abstract "Abstract Thioesterases (TEs) are classified into EC 3.1.2.1 through EC 3.1.2.27 based on their activities on different substrates, with many remaining unclassified (EC 3.1.2.–). Analysis of primary and tertiary structures of known TEs casts a new light on this enzyme group. We used strong primary sequence conservation based on experimentally proved proteins as the main criterion, followed by verification with tertiary structure superpositions, mechanisms, and catalytic residue positions, to accurately define TE families. At present, TEs fall into 23 families almost completely unrelated to each other by primary structure. It is assumed that all members of the same family have essentially the same tertiary structure; however, TEs in different families can have markedly different folds and mechanisms. Conversely, the latter sometimes have very similar tertiary structures and catalytic mechanisms despite being only slightly or not at all related by primary structure, indicating that they have common distant ancestors and can be grouped into clans. At present, four clans encompass 12 TE families. The new constantly updated ThYme (Thioester‐active enzYmes) database contains TE primary and tertiary structures, classified into families and clans that are different from those currently found in the literature or in other databases. We review all types of TEs, including those cleaving CoA, ACP, glutathione, and other protein molecules, and we discuss their structures, functions, and mechanisms." @default.
• W2147722966 created "2016-06-24" @default.
• W2147722966 creator A5016172590 @default.
• W2147722966 creator A5048901542 @default.
• W2147722966 creator A5084273701 @default.
• W2147722966 date "2010-06-23" @default.
• W2147722966 modified "2023-10-17" @default.
• W2147722966 title "Thioesterases: A new perspective based on their primary and tertiary structures" @default.
• W2147722966 cites W1504840644 @default.
• W2147722966 cites W1505742720 @default.
• W2147722966 cites W1513416306 @default.
• W2147722966 cites W1546743612 @default.
• W2147722966 cites W1557863639 @default.
• W2147722966 cites W1577743463 @default.
• W2147722966 cites W1594165376 @default.
• W2147722966 cites W1803824009 @default.
• W2147722966 cites W1855537617 @default.
• W2147722966 cites W1935793071 @default.
• W2147722966 cites W1964161751 @default.
• W2147722966 cites W1969883879 @default.
• W2147722966 cites W1970047246 @default.
• W2147722966 cites W1985917132 @default.
• W2147722966 cites W1986103520 @default.
• W2147722966 cites W1987062044 @default.
• W2147722966 cites W1988585330 @default.
• W2147722966 cites W198863919 @default.
• W2147722966 cites W1995522994 @default.
• W2147722966 cites W1998485639 @default.
• W2147722966 cites W2006429667 @default.
• W2147722966 cites W2017520720 @default.
• W2147722966 cites W2020848561 @default.
• W2147722966 cites W2021655853 @default.
• W2147722966 cites W2021863715 @default.
• W2147722966 cites W2024201380 @default.
• W2147722966 cites W2025756195 @default.
• W2147722966 cites W2033738091 @default.
• W2147722966 cites W2034503456 @default.
• W2147722966 cites W2038057037 @default.
• W2147722966 cites W2046477260 @default.
• W2147722966 cites W2047316348 @default.
• W2147722966 cites W2047745952 @default.
• W2147722966 cites W2047899898 @default.
• W2147722966 cites W2049298424 @default.
• W2147722966 cites W2050590566 @default.
• W2147722966 cites W2050859221 @default.
• W2147722966 cites W2056959025 @default.
• W2147722966 cites W2059831744 @default.
• W2147722966 cites W2075872804 @default.
• W2147722966 cites W2076533036 @default.
• W2147722966 cites W2078712188 @default.
• W2147722966 cites W2085277871 @default.
• W2147722966 cites W2091008703 @default.
• W2147722966 cites W2103575786 @default.
• W2147722966 cites W2104291840 @default.
• W2147722966 cites W2108929776 @default.
• W2147722966 cites W2111137924 @default.
• W2147722966 cites W2111938621 @default.
• W2147722966 cites W2116302357 @default.
• W2147722966 cites W2116459264 @default.
• W2147722966 cites W2122550809 @default.
• W2147722966 cites W2129448726 @default.
• W2147722966 cites W2132169354 @default.
• W2147722966 cites W2139725471 @default.
• W2147722966 cites W2140752937 @default.
• W2147722966 cites W2144304328 @default.
• W2147722966 cites W2144794307 @default.
• W2147722966 cites W2150781124 @default.
• W2147722966 cites W2150925238 @default.
• W2147722966 cites W2153160348 @default.
• W2147722966 cites W2158714788 @default.
• W2147722966 cites W2162884305 @default.
• W2147722966 cites W2166118605 @default.
• W2147722966 cites W2255950054 @default.
• W2147722966 cites W2414307244 @default.
• W2147722966 cites W4210623056 @default.
• W2147722966 cites W4211054902 @default.
• W2147722966 cites W4212865600 @default.
• W2147722966 cites W4241224397 @default.
• W2147722966 cites W4251174927 @default.
• W2147722966 cites W6616626 @default.
• W2147722966 doi "https://doi.org/10.1002/pro.417" @default.
• W2147722966 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2974821" @default.
• W2147722966 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20506386" @default.
• W2147722966 hasPublicationYear "2010" @default.
• W2147722966 type Work @default.
• W2147722966 sameAs 2147722966 @default.
• W2147722966 citedByCount "120" @default.
• W2147722966 countsByYear W21477229662012 @default.
• W2147722966 countsByYear W21477229662013 @default.
• W2147722966 countsByYear W21477229662014 @default.
• W2147722966 countsByYear W21477229662015 @default.
• W2147722966 countsByYear W21477229662016 @default.
• W2147722966 countsByYear W21477229662017 @default.
• W2147722966 countsByYear W21477229662018 @default.
• W2147722966 countsByYear W21477229662019 @default.
• W2147722966 countsByYear W21477229662020 @default.
• W2147722966 countsByYear W21477229662021 @default.
• W2147722966 countsByYear W21477229662022 @default.

• next