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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147736714> ?p ?o ?g. }

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• W2147736714 abstract "As part of our program on Tn-specific anti-tumor immunotherapy, our aim was to vary the nature of the aglyconic part of the tumor-associated Tn antigen (α-d-GalNAc-Ser/Thr). This report describes the synthesis of Fmoc-hSer-(α-d-GalNAc)-OH (4) in 19% overall yield from protected aspartic acid. The building block 4 was incorporated as trimeric clusters into a glycopeptide vaccine [MAG:Tn(hSer)3-PV], using solid-phase peptide synthesis. When injected in mice, the resulting MAG induces a strong antibody response, which recognizes native tumor-associated antigens (TAA) at the surface of human tumor cells. This approach may be extended to the use of other nonnatural TAA in order to improve half-life of synthetic anti-cancer vaccines." @default.
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• W2147736714 date "2004-07-01" @default.
• W2147736714 modified "2023-09-25" @default.
• W2147736714 title "Synthesis and immunological evaluation of an antitumor neoglycopeptide vaccine bearing a novel homoserine Tn antigen" @default.
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• W2147736714 doi "https://doi.org/10.1016/j.bmcl.2004.04.047" @default.
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