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• W2147741085 abstract "The inhibitory neurotransmitter GABA plays a crucial role in anxiety and fear, but its relationship to brain activation during fear reactions is not clear. Previous studies suggest that GABA agonists lead to an attenuation of emotion-processing related BOLD signals in the insula. The aim of this study was to investigate the relationship between GABA concentration and fear-related BOLD responses in this region. In 44 female participants with different levels of fearfulness, GABA concentration in the left insula was measured using a GABA+ MRS acquisition during rest; additionally, BOLD signals were obtained during performance of a fear provocation paradigm. Fearfulness was not associated with GABA+ in the left insula, but could predict fear-related BOLD responses in a cluster in the left anterior insula. The BOLD signal change in this cluster did not correlate with GABA+ concentration. However, we found a significant positive correlation between GABA+ concentration and fear-related BOLD responses in a different cluster that included parts of the left insula, amygdala and putamen. Our findings indicate that low insular GABA concentration is not a predisposition for fearfulness, and that several factors influence whether a correlation between GABA and BOLD can be found." @default.
• W2147741085 created "2016-06-24" @default.
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• W2147741085 date "2015-03-26" @default.
• W2147741085 modified "2023-10-17" @default.
• W2147741085 title "The Relationship between Fearfulness, GABA+, and Fear-Related BOLD Responses in the Insula" @default.
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• W2147741085 doi "https://doi.org/10.1371/journal.pone.0120101" @default.
• W2147741085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4374765" @default.
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