FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147753291> ?p ?o ?g. }

• W2147753291 endingPage "11" @default.
• W2147753291 startingPage "2006" @default.
• W2147753291 abstract "In recent years, a combination of two demographic phenomena, an increase in the number of older people in the population and an increase in the incidence of lung cancer with age, has made it mandatory to develop therapeutic modalities with less toxicity for the treatment of inoperable elderly patients with lung cancer. Our study shows that a cyclooxygenase (COX)-2 inhibitor, nimesulide, can inhibit proliferation of non-small cell lung cancer cell lines in vitro in a dose-dependent manner, in part by inducing apoptosis even at clinically achievable low concentrations. Our observations also suggest that the responsiveness of non-small cell lung cancer to COX-2 inhibitors does not require the presence of wild-type p53, but may be influenced by the degree of COX-2 expression. In addition, we found that nimesulide, when used in combination at clinically achievable concentrations, reduced the IC50 values of various anticancer agents by up to 77%, although the level of reduction varied considerably. Because our previous studies have indicated a significantly increased COX-2 expression in up to 70% of adenocarcinoma cases, the present findings are of great clinical interest. In conjunction with the recent development of next generation, highly selective COX-2 inhibitors, they can be expected to lead to even greater efficacy of their use as adjuncts to various anticancer agents for the treatment of high-risk patients without compromising their quality of life." @default.
• W2147753291 created "2016-06-24" @default.
• W2147753291 creator A5012798813 @default.
• W2147753291 creator A5025926501 @default.
• W2147753291 creator A5051273784 @default.
• W2147753291 creator A5059955082 @default.
• W2147753291 creator A5061491407 @default.
• W2147753291 creator A5077700276 @default.
• W2147753291 creator A5081110935 @default.
• W2147753291 creator A5086229141 @default.
• W2147753291 creator A5090236371 @default.
• W2147753291 date "2000-05-01" @default.
• W2147753291 modified "2023-09-26" @default.
• W2147753291 title "Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines." @default.
• W2147753291 cites W1506887248 @default.
• W2147753291 cites W1579641819 @default.
• W2147753291 cites W1879435060 @default.
• W2147753291 cites W1937967370 @default.
• W2147753291 cites W1978504806 @default.
• W2147753291 cites W1979892584 @default.
• W2147753291 cites W1985892376 @default.
• W2147753291 cites W2001160141 @default.
• W2147753291 cites W2017205892 @default.
• W2147753291 cites W2048152958 @default.
• W2147753291 cites W2057257609 @default.
• W2147753291 cites W2065447230 @default.
• W2147753291 cites W2079571554 @default.
• W2147753291 cites W2082896226 @default.
• W2147753291 cites W2089923844 @default.
• W2147753291 cites W2090106927 @default.
• W2147753291 cites W2096530472 @default.
• W2147753291 cites W2114733293 @default.
• W2147753291 cites W2117580825 @default.
• W2147753291 cites W2120850551 @default.
• W2147753291 cites W2125852497 @default.
• W2147753291 cites W2130947513 @default.
• W2147753291 cites W2134961964 @default.
• W2147753291 cites W2149987837 @default.
• W2147753291 cites W2165494849 @default.
• W2147753291 cites W2170720478 @default.
• W2147753291 cites W3142144633 @default.
• W2147753291 cites W3149002266 @default.
• W2147753291 cites W1959371471 @default.
• W2147753291 cites W2398586432 @default.
• W2147753291 cites W2411828876 @default.
• W2147753291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10815926" @default.
• W2147753291 hasPublicationYear "2000" @default.
• W2147753291 type Work @default.
• W2147753291 sameAs 2147753291 @default.
• W2147753291 citedByCount "123" @default.
• W2147753291 countsByYear W21477532912012 @default.
• W2147753291 countsByYear W21477532912013 @default.
• W2147753291 countsByYear W21477532912014 @default.
• W2147753291 countsByYear W21477532912015 @default.
• W2147753291 countsByYear W21477532912016 @default.
• W2147753291 countsByYear W21477532912017 @default.
• W2147753291 countsByYear W21477532912018 @default.
• W2147753291 countsByYear W21477532912019 @default.
• W2147753291 countsByYear W21477532912020 @default.
• W2147753291 countsByYear W21477532912023 @default.
• W2147753291 crossrefType "journal-article" @default.
• W2147753291 hasAuthorship W2147753291A5012798813 @default.
• W2147753291 hasAuthorship W2147753291A5025926501 @default.
• W2147753291 hasAuthorship W2147753291A5051273784 @default.
• W2147753291 hasAuthorship W2147753291A5059955082 @default.
• W2147753291 hasAuthorship W2147753291A5061491407 @default.
• W2147753291 hasAuthorship W2147753291A5077700276 @default.
• W2147753291 hasAuthorship W2147753291A5081110935 @default.
• W2147753291 hasAuthorship W2147753291A5086229141 @default.
• W2147753291 hasAuthorship W2147753291A5090236371 @default.
• W2147753291 hasConcept C109316439 @default.
• W2147753291 hasConcept C121608353 @default.
• W2147753291 hasConcept C126322002 @default.
• W2147753291 hasConcept C181199279 @default.
• W2147753291 hasConcept C190283241 @default.
• W2147753291 hasConcept C202751555 @default.
• W2147753291 hasConcept C2776256026 @default.
• W2147753291 hasConcept C2777570176 @default.
• W2147753291 hasConcept C2779689624 @default.
• W2147753291 hasConcept C2781182431 @default.
• W2147753291 hasConcept C2908647359 @default.
• W2147753291 hasConcept C29730261 @default.
• W2147753291 hasConcept C502942594 @default.
• W2147753291 hasConcept C55493867 @default.
• W2147753291 hasConcept C71924100 @default.
• W2147753291 hasConcept C86803240 @default.
• W2147753291 hasConcept C98274493 @default.
• W2147753291 hasConcept C99454951 @default.
• W2147753291 hasConceptScore W2147753291C109316439 @default.
• W2147753291 hasConceptScore W2147753291C121608353 @default.
• W2147753291 hasConceptScore W2147753291C126322002 @default.
• W2147753291 hasConceptScore W2147753291C181199279 @default.
• W2147753291 hasConceptScore W2147753291C190283241 @default.
• W2147753291 hasConceptScore W2147753291C202751555 @default.
• W2147753291 hasConceptScore W2147753291C2776256026 @default.
• W2147753291 hasConceptScore W2147753291C2777570176 @default.
• W2147753291 hasConceptScore W2147753291C2779689624 @default.
• W2147753291 hasConceptScore W2147753291C2781182431 @default.

• next