FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147788336> ?p ?o ?g. }

• W2147788336 endingPage "9056" @default.
• W2147788336 startingPage "9051" @default.
• W2147788336 abstract "The assembly of the polyketide backbone of rifamycin B on the type I rifamycin polyketide synthase (PKS), encoded by the rifA-rifE genes, is terminated by the product of the rifF gene, an amide synthase that releases the completed undecaketide as its macrocyclic lactam. Inactivation of rifF gives a rifamycin B nonproducing mutant that still accumulates a series of linear polyketides ranging from the tetra- to a decaketide, also detected in the wild type, demonstrating that the PKS operates in a processive manner. Disruptions of the rifD module 8 and rifE module 9 and module 10 genes also result in accumulation of such linear polyketides as a consequence of premature termination of polyketide assembly. Whereas the tetraketide carries an unmodified aromatic chromophore, the penta- through decaketides have undergone oxidative cyclization to the naphthoquinone, suggesting that this modification occurs during, not after, PKS assembly. The structure of one of the accumulated compounds together with (18)O experiments suggests that this oxidative cyclization produces an 8-hydroxy-7, 8-dihydronaphthoquinone structure that, after the stage of proansamycin X, is dehydrogenated to an 8-hydroxynaphthoquinone." @default.
• W2147788336 created "2016-06-24" @default.
• W2147788336 creator A5005728746 @default.
• W2147788336 creator A5019744998 @default.
• W2147788336 creator A5023510640 @default.
• W2147788336 creator A5027410094 @default.
• W2147788336 creator A5042160264 @default.
• W2147788336 creator A5049605634 @default.
• W2147788336 creator A5054515311 @default.
• W2147788336 creator A5065125027 @default.
• W2147788336 date "1999-08-03" @default.
• W2147788336 modified "2023-09-24" @default.
• W2147788336 title "Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively" @default.
• W2147788336 cites W1580220829 @default.
• W2147788336 cites W1940257192 @default.
• W2147788336 cites W1978128362 @default.
• W2147788336 cites W1978336624 @default.
• W2147788336 cites W1985233270 @default.
• W2147788336 cites W1993274596 @default.
• W2147788336 cites W1998591058 @default.
• W2147788336 cites W2005585005 @default.
• W2147788336 cites W2008733674 @default.
• W2147788336 cites W2014983811 @default.
• W2147788336 cites W2022988477 @default.
• W2147788336 cites W2024892153 @default.
• W2147788336 cites W2028622989 @default.
• W2147788336 cites W2030257519 @default.
• W2147788336 cites W2047504670 @default.
• W2147788336 cites W2064397676 @default.
• W2147788336 cites W2068904968 @default.
• W2147788336 cites W2078798579 @default.
• W2147788336 cites W2082734817 @default.
• W2147788336 cites W2084127435 @default.
• W2147788336 cites W2099677169 @default.
• W2147788336 cites W2121513555 @default.
• W2147788336 cites W2128045546 @default.
• W2147788336 cites W2214685187 @default.
• W2147788336 cites W2322870763 @default.
• W2147788336 cites W2463896119 @default.
• W2147788336 cites W2978090003 @default.
• W2147788336 cites W4240688319 @default.
• W2147788336 cites W4246822974 @default.
• W2147788336 doi "https://doi.org/10.1073/pnas.96.16.9051" @default.
• W2147788336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/17730" @default.
• W2147788336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10430893" @default.
• W2147788336 hasPublicationYear "1999" @default.
• W2147788336 type Work @default.
• W2147788336 sameAs 2147788336 @default.
• W2147788336 citedByCount "126" @default.
• W2147788336 countsByYear W21477883362012 @default.
• W2147788336 countsByYear W21477883362013 @default.
• W2147788336 countsByYear W21477883362014 @default.
• W2147788336 countsByYear W21477883362015 @default.
• W2147788336 countsByYear W21477883362016 @default.
• W2147788336 countsByYear W21477883362017 @default.
• W2147788336 countsByYear W21477883362018 @default.
• W2147788336 countsByYear W21477883362019 @default.
• W2147788336 countsByYear W21477883362020 @default.
• W2147788336 countsByYear W21477883362021 @default.
• W2147788336 countsByYear W21477883362022 @default.
• W2147788336 countsByYear W21477883362023 @default.
• W2147788336 crossrefType "journal-article" @default.
• W2147788336 hasAuthorship W2147788336A5005728746 @default.
• W2147788336 hasAuthorship W2147788336A5019744998 @default.
• W2147788336 hasAuthorship W2147788336A5023510640 @default.
• W2147788336 hasAuthorship W2147788336A5027410094 @default.
• W2147788336 hasAuthorship W2147788336A5042160264 @default.
• W2147788336 hasAuthorship W2147788336A5049605634 @default.
• W2147788336 hasAuthorship W2147788336A5054515311 @default.
• W2147788336 hasAuthorship W2147788336A5065125027 @default.
• W2147788336 hasBestOaLocation W21477883362 @default.
• W2147788336 hasConcept C104317684 @default.
• W2147788336 hasConcept C112243037 @default.
• W2147788336 hasConcept C143065580 @default.
• W2147788336 hasConcept C185592680 @default.
• W2147788336 hasConcept C2776306059 @default.
• W2147788336 hasConcept C2777763344 @default.
• W2147788336 hasConcept C2778635478 @default.
• W2147788336 hasConcept C501593827 @default.
• W2147788336 hasConcept C553450214 @default.
• W2147788336 hasConcept C55493867 @default.
• W2147788336 hasConcept C71240020 @default.
• W2147788336 hasConcept C86803240 @default.
• W2147788336 hasConceptScore W2147788336C104317684 @default.
• W2147788336 hasConceptScore W2147788336C112243037 @default.
• W2147788336 hasConceptScore W2147788336C143065580 @default.
• W2147788336 hasConceptScore W2147788336C185592680 @default.
• W2147788336 hasConceptScore W2147788336C2776306059 @default.
• W2147788336 hasConceptScore W2147788336C2777763344 @default.
• W2147788336 hasConceptScore W2147788336C2778635478 @default.
• W2147788336 hasConceptScore W2147788336C501593827 @default.
• W2147788336 hasConceptScore W2147788336C553450214 @default.
• W2147788336 hasConceptScore W2147788336C55493867 @default.
• W2147788336 hasConceptScore W2147788336C71240020 @default.
• W2147788336 hasConceptScore W2147788336C86803240 @default.
• W2147788336 hasIssue "16" @default.
• W2147788336 hasLocation W21477883361 @default.
• W2147788336 hasLocation W21477883362 @default.

• next