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- W2147810865 abstract "With the intent of contributing to a carbohydrate-based vaccine against the gastroduodenal pathogen, Helicobacter pylori, we report here the structure of cell-surface mannans obtained from a virulent strain. Unlike other wild-type strains, this strain was found to express in good quantities this polysaccharide in vitro. Structural analysis revealed a branched mannan formed by a backbone of α-(1→6)-linked mannopyranosyl residues with approximately 80% branching at the O-2 position. The branches were composed of O-2-linked Man residues in both α- and β-configurations: In addition, this strain also expressed cell-surface emblematic H. pylori lipopolysaccharides (LPS) containing partially fucosylated polyLacNAc O-chains. Affinity assays with polymyxin-B and concanavalin A revealed no association between the mannan and the LPS. The described mannans may be implicated in the mediation of host–microbial interactions and immunological modulation." @default.
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- W2147810865 date "2010-04-01" @default.
- W2147810865 modified "2023-10-07" @default.
- W2147810865 title "Identification of cell-surface mannans in a virulent Helicobacter pylori strain" @default.
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- W2147810865 doi "https://doi.org/10.1016/j.carres.2010.01.022" @default.
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