FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147825834> ?p ?o ?g. }

• W2147825834 endingPage "42" @default.
• W2147825834 startingPage "29" @default.
• W2147825834 abstract ": To quantify through systematic review the pharmacokinetic profiles of the oral delayed release and sustained release mesalazine (5-aminosalicylate, 5ASA) formulations (Asacol, Salofalk, Mesasal, Claversal, Pentasa) and pro-drugs (sulfasalazine, olsalazine, balsalazide) used in the management of ulcerative colitis.: Selected articles had: (1) adult healthy volunteers or patients with ulcerative colitis and (2) quantification of pharmacokinetic data to include, at a minimum, urinary excretion of total 5ASA [5ASA plus N-Acetyl-5ASA (N-Ac-5ASA)].: Pharmacokinetic data (Tmax, Cmax, AUC, urinary excretion, faecal excretion) of 5ASA, its major metabolite N-Acetyl-5ASA, total 5ASA, and the parent pro-drug compounds was extracted.: The summary results for urinary excretion of total 5ASA over 24-96 h in all subjects (either mean or median) were: sulfasalazine mean 11-33% or median 22%; olsalazine mean 14-31% or median 16-27%; balsalazide mean 12-35% or median 20%; Asacol mean 10-35% or median 18-40%; Pentasa mean 15-53% or median 23-34%; Salofalk, Mesasal and Claversal mean 27-56% or median 31-44%. The summary results for faecal excretion of total 5ASA over 24-96 h in all subjects (either mean or median) were: sulfasalazine mean 23-75% or median 38%; olsalazine mean 47-50% or median 17-36%; balsalazide mean 46% or median 22%; Asacol mean 40-64% or median 20-56%; Pentasa mean 12-51% or median 39-59%; Salofalk, Mesasal and Claversal mean 37-44% or median 23-35%.: The systemic exposure to 5ASA, as measured by urinary excretion of total 5ASA, and the faecal excretion of total 5ASA is comparable for all oral mesalazine formulations and pro-drugs. Thus, selection of a mesalazine therapy for the treatment of ulcerative colitis should be based on other factors such as efficacy, dose-response, toxicity of the parent compound and its metabolites, compliance issues related to dose forms and dosing schedules, and costs." @default.
• W2147825834 created "2016-06-24" @default.
• W2147825834 creator A5011739304 @default.
• W2147825834 creator A5032150391 @default.
• W2147825834 date "2002-12-19" @default.
• W2147825834 modified "2023-10-16" @default.
• W2147825834 title "The pharmacokinetic profiles of oral mesalazine formulations and mesalazine pro-drugs used in the management of ulcerative colitis" @default.
• W2147825834 cites W1497372115 @default.
• W2147825834 cites W1566382259 @default.
• W2147825834 cites W1770909803 @default.
• W2147825834 cites W1964233609 @default.
• W2147825834 cites W1967855063 @default.
• W2147825834 cites W1968585966 @default.
• W2147825834 cites W1972025604 @default.
• W2147825834 cites W1973960461 @default.
• W2147825834 cites W1975062518 @default.
• W2147825834 cites W1979915837 @default.
• W2147825834 cites W1981461721 @default.
• W2147825834 cites W1981655586 @default.
• W2147825834 cites W1989296532 @default.
• W2147825834 cites W1989737284 @default.
• W2147825834 cites W1989738331 @default.
• W2147825834 cites W1989740133 @default.
• W2147825834 cites W1992011494 @default.
• W2147825834 cites W1995524658 @default.
• W2147825834 cites W1995574368 @default.
• W2147825834 cites W1997310223 @default.
• W2147825834 cites W1998652812 @default.
• W2147825834 cites W2001257866 @default.
• W2147825834 cites W2002334833 @default.
• W2147825834 cites W2007418676 @default.
• W2147825834 cites W2008160869 @default.
• W2147825834 cites W2010759737 @default.
• W2147825834 cites W2010946554 @default.
• W2147825834 cites W2013523908 @default.
• W2147825834 cites W2014823088 @default.
• W2147825834 cites W2015247015 @default.
• W2147825834 cites W2016177114 @default.
• W2147825834 cites W2017167069 @default.
• W2147825834 cites W2021942122 @default.
• W2147825834 cites W2024513902 @default.
• W2147825834 cites W2028790092 @default.
• W2147825834 cites W2032467642 @default.
• W2147825834 cites W2038686392 @default.
• W2147825834 cites W2040547481 @default.
• W2147825834 cites W2040989977 @default.
• W2147825834 cites W2043530745 @default.
• W2147825834 cites W2043849011 @default.
• W2147825834 cites W2044507601 @default.
• W2147825834 cites W2047890250 @default.
• W2147825834 cites W2051214135 @default.
• W2147825834 cites W2053585254 @default.
• W2147825834 cites W2055703654 @default.
• W2147825834 cites W2056817635 @default.
• W2147825834 cites W2064884790 @default.
• W2147825834 cites W2065780155 @default.
• W2147825834 cites W2067447558 @default.
• W2147825834 cites W2068208094 @default.
• W2147825834 cites W2068787312 @default.
• W2147825834 cites W2072029446 @default.
• W2147825834 cites W2073759704 @default.
• W2147825834 cites W2075833014 @default.
• W2147825834 cites W2081067304 @default.
• W2147825834 cites W2081817010 @default.
• W2147825834 cites W2082034492 @default.
• W2147825834 cites W2090568923 @default.
• W2147825834 cites W2090862846 @default.
• W2147825834 cites W2093597086 @default.
• W2147825834 cites W2096326818 @default.
• W2147825834 cites W2097224532 @default.
• W2147825834 cites W2101144507 @default.
• W2147825834 cites W2106863712 @default.
• W2147825834 cites W2114959701 @default.
• W2147825834 cites W2115191750 @default.
• W2147825834 cites W2118585077 @default.
• W2147825834 cites W2122172476 @default.
• W2147825834 cites W2125850304 @default.
• W2147825834 cites W2129810742 @default.
• W2147825834 cites W2135287750 @default.
• W2147825834 cites W2142189674 @default.
• W2147825834 cites W2161667176 @default.
• W2147825834 cites W2165763417 @default.
• W2147825834 cites W2179681930 @default.
• W2147825834 cites W2327240012 @default.
• W2147825834 cites W2330671277 @default.
• W2147825834 cites W2402295257 @default.
• W2147825834 cites W2414745158 @default.
• W2147825834 cites W2415775034 @default.
• W2147825834 cites W2435135945 @default.
• W2147825834 cites W26437379 @default.
• W2147825834 cites W267429781 @default.
• W2147825834 cites W4236303975 @default.
• W2147825834 cites W4247882274 @default.
• W2147825834 cites W47417504 @default.
• W2147825834 doi "https://doi.org/10.1046/j.1365-2036.2003.01408.x" @default.
• W2147825834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12492730" @default.
• W2147825834 hasPublicationYear "2002" @default.
• W2147825834 type Work @default.

• next