FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147882005> ?p ?o ?g. }

• W2147882005 endingPage "54" @default.
• W2147882005 startingPage "147" @default.
• W2147882005 abstract "Carbamazepine (CBZ), one of the most commonly prescribed antiepileptic drug, is proposed to inhibit Na+ channel. In this study, we have investigated the effects of CBZ on Na+ current, evoked in cultured dorsal root ganglion (DRG) neurons from neonatal rats using whole cell patch clamp technique. In small DRG neurons (20-25 microm), Na+ current was obtained by blocking K+ and Ca2+ currents with appropriate ion replacement and channel blockers. Separation of the Na+ current components was achieved on the basis of response to the conditioning voltage. The CBZ depressed Na+ current in a dose-dependent manner. The maximal Na+ current was depressed at 300 microM of CBZ, where 94 +/- 5.1% of depression was observed. The depression of normalized current amplitude was found to be 72 +/- 13.2%, 84 +/- 10%, 85 +/- 7.1% and 95 +/- 5.2% at 10, 30, 100 and 300 microM of CBZ concentrations, respectively, at -20 mV test pulse, when compared with control. The depression of current amplitude was observed as 48 +/- 12.3%, 42 +/- 15.2%, 71 +/- 17.7% and 90 +/- 5.8% at 10, 30, 100 and 300 microM of CBZ concentration, respectively, at 0 mV voltage pulse. The depression of Na+ currents was found to be dose-dependant at -20 and -10 mV but not at 0 mV, It is concluded that the depression of Na+ currents by CBZ may be responsible for inhibiting the neurotransmitter release." @default.
• W2147882005 created "2016-06-24" @default.
• W2147882005 creator A5036437604 @default.
• W2147882005 creator A5039538410 @default.
• W2147882005 creator A5049334420 @default.
• W2147882005 creator A5056613177 @default.
• W2147882005 date "2010-02-02" @default.
• W2147882005 modified "2023-09-27" @default.
• W2147882005 title "Inhibition of sodium current by carbamazepine in dorsal root ganglion neurons in vitro." @default.
• W2147882005 cites W1561891673 @default.
• W2147882005 cites W1936127814 @default.
• W2147882005 cites W1943887740 @default.
• W2147882005 cites W1966818330 @default.
• W2147882005 cites W1989005471 @default.
• W2147882005 cites W2024451662 @default.
• W2147882005 cites W2030635010 @default.
• W2147882005 cites W2034148756 @default.
• W2147882005 cites W2040844744 @default.
• W2147882005 cites W2059179170 @default.
• W2147882005 cites W2065798366 @default.
• W2147882005 cites W2075124113 @default.
• W2147882005 cites W2097051377 @default.
• W2147882005 cites W2117531417 @default.
• W2147882005 cites W2125034247 @default.
• W2147882005 cites W2137702351 @default.
• W2147882005 cites W2305369714 @default.
• W2147882005 cites W2412469287 @default.
• W2147882005 cites W2416337138 @default.
• W2147882005 cites W299137714 @default.
• W2147882005 cites W2339488300 @default.
• W2147882005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20112818" @default.
• W2147882005 hasPublicationYear "2010" @default.
• W2147882005 type Work @default.
• W2147882005 sameAs 2147882005 @default.
• W2147882005 citedByCount "2" @default.
• W2147882005 countsByYear W21478820052015 @default.
• W2147882005 countsByYear W21478820052018 @default.
• W2147882005 crossrefType "journal-article" @default.
• W2147882005 hasAuthorship W2147882005A5036437604 @default.
• W2147882005 hasAuthorship W2147882005A5039538410 @default.
• W2147882005 hasAuthorship W2147882005A5049334420 @default.
• W2147882005 hasAuthorship W2147882005A5056613177 @default.
• W2147882005 hasConcept C105702510 @default.
• W2147882005 hasConcept C12554922 @default.
• W2147882005 hasConcept C126322002 @default.
• W2147882005 hasConcept C140530291 @default.
• W2147882005 hasConcept C147944092 @default.
• W2147882005 hasConcept C153461711 @default.
• W2147882005 hasConcept C169760540 @default.
• W2147882005 hasConcept C178790620 @default.
• W2147882005 hasConcept C185263204 @default.
• W2147882005 hasConcept C185592680 @default.
• W2147882005 hasConcept C2776281502 @default.
• W2147882005 hasConcept C2777151030 @default.
• W2147882005 hasConcept C2778186239 @default.
• W2147882005 hasConcept C2779253243 @default.
• W2147882005 hasConcept C42219234 @default.
• W2147882005 hasConcept C50952357 @default.
• W2147882005 hasConcept C519063684 @default.
• W2147882005 hasConcept C537181965 @default.
• W2147882005 hasConcept C71924100 @default.
• W2147882005 hasConcept C86803240 @default.
• W2147882005 hasConcept C98274493 @default.
• W2147882005 hasConceptScore W2147882005C105702510 @default.
• W2147882005 hasConceptScore W2147882005C12554922 @default.
• W2147882005 hasConceptScore W2147882005C126322002 @default.
• W2147882005 hasConceptScore W2147882005C140530291 @default.
• W2147882005 hasConceptScore W2147882005C147944092 @default.
• W2147882005 hasConceptScore W2147882005C153461711 @default.
• W2147882005 hasConceptScore W2147882005C169760540 @default.
• W2147882005 hasConceptScore W2147882005C178790620 @default.
• W2147882005 hasConceptScore W2147882005C185263204 @default.
• W2147882005 hasConceptScore W2147882005C185592680 @default.
• W2147882005 hasConceptScore W2147882005C2776281502 @default.
• W2147882005 hasConceptScore W2147882005C2777151030 @default.
• W2147882005 hasConceptScore W2147882005C2778186239 @default.
• W2147882005 hasConceptScore W2147882005C2779253243 @default.
• W2147882005 hasConceptScore W2147882005C42219234 @default.
• W2147882005 hasConceptScore W2147882005C50952357 @default.
• W2147882005 hasConceptScore W2147882005C519063684 @default.
• W2147882005 hasConceptScore W2147882005C537181965 @default.
• W2147882005 hasConceptScore W2147882005C71924100 @default.
• W2147882005 hasConceptScore W2147882005C86803240 @default.
• W2147882005 hasConceptScore W2147882005C98274493 @default.
• W2147882005 hasIssue "2" @default.
• W2147882005 hasLocation W21478820051 @default.
• W2147882005 hasOpenAccess W2147882005 @default.
• W2147882005 hasPrimaryLocation W21478820051 @default.
• W2147882005 hasRelatedWork W137096887 @default.
• W2147882005 hasRelatedWork W1976064956 @default.
• W2147882005 hasRelatedWork W1979456296 @default.
• W2147882005 hasRelatedWork W2004413159 @default.
• W2147882005 hasRelatedWork W2018192328 @default.
• W2147882005 hasRelatedWork W2018481858 @default.
• W2147882005 hasRelatedWork W2034361715 @default.
• W2147882005 hasRelatedWork W2035407885 @default.
• W2147882005 hasRelatedWork W2043930136 @default.
• W2147882005 hasRelatedWork W2066240691 @default.

• next