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- W2147884196 abstract "Theophylline and three lipolytic agents, 2,5-bis(2- chloroethylsulfonyl)-pyrrole-3,4-dicarbonitrile (substituted pyr- role), 2,4-diamino-6-butoxy-s-triazine (substituted triazine), and 2,3-dihydro-5,6-dimethyl-3-oxo-4-pyridazinecarbonitrile (substituted pyridazine), stimulate basal lipolysis in adipose tissue in vitro. They also cause an increased release of free fatty acids, but not glycerol, from adipose tissue in which lipolysis is already maximally stimulated by epinephrine. The four compounds also inhibit cyclic AMP phosphodiesterase and the conversion of (1-14C)glucose to 14C02. Evidence is presented that free fatty acids accumulate as the result of in- hibited reesterification. The substituted pyridazine and tri- azine, but not the pyrrole, elevate plasma free fatty acids after oral or intraperitoneal administration in rats. Supplementary key words plasma free fatty acids . 2,3-dihy- dro-5,6-dimethyl-3-oxo-4-pyridazinecarbonitrile . 2,5-bis(2-chloro- ethylsulfonyl)-pyrrole-3,4-dicarbonitrile . 2,4-diamino-6-butoxy- s-triazine THAT THEOPHYLLINE stimulates lipolysis in adipose" @default.
- W2147884196 created "2016-06-24" @default.
- W2147884196 creator A5016819663 @default.
- W2147884196 date "1973-03-01" @default.
- W2147884196 modified "2023-09-26" @default.
- W2147884196 title "Lipolysis and reesterification: effects of some inhibitors of adenosine 3′,5′-cyclic monophosphate phosphodiesterase" @default.
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- W2147884196 doi "https://doi.org/10.1016/s0022-2275(20)36914-5" @default.
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