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• W2147889964 abstract "Medir la efectividad y seguridad de imatinib en los tumores del estroma gastrointestinal (GIST). Estudio retrospectivo desde el año 1993 hasta junio de 2005 donde se identificaron todos los pacientes diagnosticados de GIST por anatomía patológica, y se revisaron historias clínicas de los tratados con imatinib. Se recogieron datos demográficos, relativos al diagnóstico, al tratamiento y a la evolución. Se identificaron 25 pacientes, 7 tratados con imatinib. La respuesta total fue de 4/7, 2/7 casos fueron respuestas completas y otros 2/7 respuestas parciales. La mediana actuarial de supervivencia libre de enfermedad alcanzada fue de 10 meses y la global 44 meses. Las reacciones adversas (RAM) recogidas fueron: 33% (5) gastrointestinales, 40% (6) dermatológicas y/o edema, 14% (2) toxicidad hematológica y 13% (2) astenia. El 2/7 pacientes no experimentaron ningún tipo de toxicidad relacionada con imatinib. En nuestra experiencia, imatinib constituye un tratamiento efectivo y de buena tolerancia para el GIST maligno [c-Kit (CD117) positivo] no resecable y/o metastásico. To measure the effectiveness and safety of imatinib for gstrointestinal stromal tumors (GISTs). A retrospective study from 1993 through June 2005 by identifying all patients diagnosed with GIST by the Pathology Department. The medical records of those treated with imatinib were reviewed. Demographic, diagnostic, therapeutic, and outcome-related data were collected. Twenty-five patients were identified, 7 of them treated with imatinib. Total responses were 4/7; 2/7 cases were complete responses, and 2/7 were partial responses. Mean actuarial disease-free survival was 10 months, and overall survival was 44 months. Adverse reactions (ARs) reported included: 33% (5) gastrointestinal events, 40% (6) dermatologic events and/or edema, 14% (2) blood toxicity, and 13% (2) asthenia. In all, 2/7 patients experienced no imatinib-related toxicity. In our experience, imatinib is an effective, well tolerated therapy for malignant [c-Kit (CD117)-positive], nonresectable and/or metastatic GIST." @default.
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• W2147889964 date "2006-01-01" @default.
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• W2147889964 title "Efectividad y seguridad de imatinib en siete casos de tumores del estroma gastrointestinal" @default.
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• W2147889964 doi "https://doi.org/10.1016/s1130-6343(06)73980-0" @default.
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