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• W2147914702 abstract "Selective and effective antimicrobial activities against Gram-positive bacteria (B. subtilis and/or S. aureus) were found in 2-coordinate gold(I)–PPh3 complexes with AuSP and AuNP cores, i.e. [Au(L)(PPh3)] (HL=2-H2mna [H2mna=mercaptonicotinic acid] 3, d-H2pen [H2pen=penicillamine] 4, d,l-H2pen 5, 4-H2mba [H2mba=mercaptobenzoic acid] 8, Hpz [Hpz=pyrazole] 9, Him [Him=imidazole] 10, 1,2,3-Htriz [Htriz=triazole] 11, 1,2,4-Htriz 12, Htetz [Htetz=tetrazole] 13), whereas no activity was observed in 2-coordinate AuSP core complexes [Au(2-Hmba)(PPh3)] 6 and [Au(3-Hmba)(PPh3)] 7. The two novel AuSP core complexes, [Au(2-Hmpa)(PPh3)] [H2mpa=mercaptopropionic acid] 1 and [Au(6-Hmna)(PPh3)] 2, were prepared and characterized by elemental analysis, FT-IR, TG/DTA, and (31P, 1H and 13C) NMR spectroscopy. The crystal structures of 1 and 2 were determined as a supramolecular arrangement of the 2-coordinate AuSP core. Both 1 and 2 significantly showed antibacterial activities. As a model reaction of phosphinegold (I) complexes with the cysteine residue in the biological ligands, we examined if the ligand exchange reactions of the aromatic anions L1− in [Au(L1)(PPh3)] (HL1=6-H2mna 2, 2-H2mna 3, 2-H2mba 6, Hpz 9, Him 10, 1,2,3-Htriz 11, 1,2,4-Htriz 12) with aliphatic thiols HL2 (HL2=2-H2mpa, d-H2pen) occurred under the mild conditions and, also, if the ‘reverse’ reactions, namely, the ligand exchange reactions of the thiolate anions in [Au(2-Hmpa)(PPh3)] 1, [Au(d-Hpen)(PPh3)] 4 and [Au(2-Hmba)(PPh3)] 6 with the free ligands HL1 took place under similar conditions. In this work, a relationship of the ligand-exchangeability among 2-coordinate gold(I) complexes (1–4, 6, 9–12) was revealed. Complex 6 was substitution-inert, whereas complexes 1–4 and 9–12 were substitution-labile. The ligand-exchangeability of Au–S and Au–N bonds in the 2-coordinate phosphinegold(I) complexes with AuSP and AuNP cores to form new AuSP cores, with retention of the Au–P bond, was closely related to the observed activities against Gram-positive bacteria, and the ease of the ligand-exchange reaction was strongly related to the intensity of the activities." @default.
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• W2147914702 date "2003-06-01" @default.
• W2147914702 modified "2023-10-18" @default.
• W2147914702 title "Ligand-exchangeability of 2-coordinate phosphinegold(I) complexes with AuSP and AuNP cores showing selective antimicrobial activities against Gram-positive bacteria. Crystal structures of [Au(2-Hmpa)(PPh3)] and [Au(6-Hmna)(PPh3)] (2-H2mpa=2-mercaptopropionic acid, 6-H2mna=6-mercaptonicotinic acid)" @default.
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• W2147914702 doi "https://doi.org/10.1016/s0162-0134(03)00125-9" @default.
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