Matches in SemOpenAlex for { <https://semopenalex.org/work/W2147918104> ?p ?o ?g. }
- W2147918104 endingPage "116" @default.
- W2147918104 startingPage "105" @default.
- W2147918104 abstract "Abstract Paraoxonase 1 (PON1) prevents oxidation of low‐density lipoproteins and inactivates toxic oxon derivatives of organophosphate pesticides (OPs). More than 250 SNPs have been previously identified in the PON1 gene, yet studies of PON1 genetic variation focus primarily on a few promoter SNPs (−108, −162) and coding SNPs (192, 55). We sequenced the PON1 gene in 30 subjects from a Mexican‐American birth cohort and identified 94 polymorphisms with minor allele frequencies >5%, including several novel variants (six SNPs, one insertion, and two deletions). Variants of the PON1 gene and three SNPs from PON2 and PON3 were genotyped in 700 children and mothers from the same cohort. PON1 phenotype was established using two substrate‐specific assays: arylesterase (AREase) and paraoxonase (POase). Twelve PON1 and two PON2 polymorphisms were significantly associated with AREase activity, and 37 polymorphisms with POase activity; however, only nine were not in strong linkage disequilibrium (LD) with either PON1 −108 or PON1 19 2 ( r 2 > 0.20), SNPs with known effects on PON1 quantity and substrate‐specific activity. Single tagSNPs PON1 55 and PON1 192 accounted for similar ranges of AREase variation compared to haplotypes comprised of multiple SNPs within their haplotype blocks. However, PON1 55 explained 11–16% of POase activity, while six SNPs in the same haplotype block explained threefold more variance (36–56%). Although LD structure in the PON cluster seems similar between Mexicans and Caucasians, allele frequencies for many polymorphisms differed strikingly. Functional effects of PON genetic variation related to susceptibility to OPs and oxidative stress also differed by age and should be considered in protecting vulnerable subpopulations. Environ. Mol. Mutagen. 52:105–116, 2011. © 2010 Wiley‐Liss, Inc." @default.
- W2147918104 created "2016-06-24" @default.
- W2147918104 creator A5001870814 @default.
- W2147918104 creator A5030022605 @default.
- W2147918104 creator A5032298497 @default.
- W2147918104 creator A5043023935 @default.
- W2147918104 creator A5059093059 @default.
- W2147918104 creator A5081625019 @default.
- W2147918104 date "2011-02-04" @default.
- W2147918104 modified "2023-10-11" @default.
- W2147918104 title "Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican-American mothers and children" @default.
- W2147918104 cites W1804086709 @default.
- W2147918104 cites W1967507582 @default.
- W2147918104 cites W1981302306 @default.
- W2147918104 cites W1989715435 @default.
- W2147918104 cites W1995527081 @default.
- W2147918104 cites W1997004368 @default.
- W2147918104 cites W2001085484 @default.
- W2147918104 cites W2008600234 @default.
- W2147918104 cites W2012709143 @default.
- W2147918104 cites W2016742004 @default.
- W2147918104 cites W2030028299 @default.
- W2147918104 cites W2030964561 @default.
- W2147918104 cites W2031527014 @default.
- W2147918104 cites W2044659011 @default.
- W2147918104 cites W2057348862 @default.
- W2147918104 cites W2058401000 @default.
- W2147918104 cites W2059228589 @default.
- W2147918104 cites W2064929307 @default.
- W2147918104 cites W2066412142 @default.
- W2147918104 cites W2068369777 @default.
- W2147918104 cites W2079354017 @default.
- W2147918104 cites W2085566853 @default.
- W2147918104 cites W2087736738 @default.
- W2147918104 cites W2099341739 @default.
- W2147918104 cites W2099620126 @default.
- W2147918104 cites W2101154649 @default.
- W2147918104 cites W2101714885 @default.
- W2147918104 cites W2107386843 @default.
- W2147918104 cites W2107950498 @default.
- W2147918104 cites W2110065044 @default.
- W2147918104 cites W2111029141 @default.
- W2147918104 cites W2113998330 @default.
- W2147918104 cites W2114409847 @default.
- W2147918104 cites W2148436597 @default.
- W2147918104 cites W2151578735 @default.
- W2147918104 cites W2152664025 @default.
- W2147918104 cites W2161414810 @default.
- W2147918104 cites W2161454698 @default.
- W2147918104 cites W2161633633 @default.
- W2147918104 cites W2162530578 @default.
- W2147918104 cites W2164259487 @default.
- W2147918104 cites W2168868948 @default.
- W2147918104 cites W2169664803 @default.
- W2147918104 cites W27779339 @default.
- W2147918104 doi "https://doi.org/10.1002/em.20567" @default.
- W2147918104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3003760" @default.
- W2147918104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20839225" @default.
- W2147918104 hasPublicationYear "2011" @default.
- W2147918104 type Work @default.
- W2147918104 sameAs 2147918104 @default.
- W2147918104 citedByCount "16" @default.
- W2147918104 countsByYear W21479181042012 @default.
- W2147918104 countsByYear W21479181042013 @default.
- W2147918104 countsByYear W21479181042014 @default.
- W2147918104 countsByYear W21479181042015 @default.
- W2147918104 countsByYear W21479181042016 @default.
- W2147918104 countsByYear W21479181042017 @default.
- W2147918104 countsByYear W21479181042018 @default.
- W2147918104 countsByYear W21479181042019 @default.
- W2147918104 countsByYear W21479181042020 @default.
- W2147918104 crossrefType "journal-article" @default.
- W2147918104 hasAuthorship W2147918104A5001870814 @default.
- W2147918104 hasAuthorship W2147918104A5030022605 @default.
- W2147918104 hasAuthorship W2147918104A5032298497 @default.
- W2147918104 hasAuthorship W2147918104A5043023935 @default.
- W2147918104 hasAuthorship W2147918104A5059093059 @default.
- W2147918104 hasAuthorship W2147918104A5081625019 @default.
- W2147918104 hasBestOaLocation W21479181042 @default.
- W2147918104 hasConcept C104317684 @default.
- W2147918104 hasConcept C134018914 @default.
- W2147918104 hasConcept C135763542 @default.
- W2147918104 hasConcept C153209595 @default.
- W2147918104 hasConcept C157410074 @default.
- W2147918104 hasConcept C180754005 @default.
- W2147918104 hasConcept C197754878 @default.
- W2147918104 hasConcept C2776151105 @default.
- W2147918104 hasConcept C2776509667 @default.
- W2147918104 hasConcept C35605836 @default.
- W2147918104 hasConcept C37501387 @default.
- W2147918104 hasConcept C54355233 @default.
- W2147918104 hasConcept C86803240 @default.
- W2147918104 hasConceptScore W2147918104C104317684 @default.
- W2147918104 hasConceptScore W2147918104C134018914 @default.
- W2147918104 hasConceptScore W2147918104C135763542 @default.
- W2147918104 hasConceptScore W2147918104C153209595 @default.
- W2147918104 hasConceptScore W2147918104C157410074 @default.
- W2147918104 hasConceptScore W2147918104C180754005 @default.