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• W2147946013 abstract "The current study aims to investigate hematological and biochemical blood indices of albino rats administrated aluminum chloride (AlCl3) for eight weeks, and to study the therapeutic effects of vitamin E and C. AlCl 3 decreased the total red blood cell count (by 18%), hemoglobin (7%) and hematocrit (20%), and increased white blood cell count (67%), lymphocytes (29%), mean corpuscular volume (14%), mean corpuscular hemaglobin (6%) and platelets (33%). Administration of vitamin E with or without vitamin C failed to restore levels of red blood cell counts, hematocrit, mean corpuscular volume, mean corpuscular hemaglobin or platelets, but vitamin E on its own restored levels of white blood cells, hemaglobin and lymphocytes. AlCl 3 decreased serum glucose levels by 30%, and increased triglyceride (28%) and cholesterol (20%) levels; neither vitamin treatments restored the levels of these components. AlCl 3 increased levels of urea (12%), uric acid (77%) and creatinine (25%) compared to the controls, and vitamin E separately or together with vitamin C restored the levels of these nitrogen compounds. The activities of alanine aminotransferase, alkaline phosphatase, and aspartate aminotransferase were also increased by the AlCl 3 treatment; the first two but not aspartate aminotransferase were restored by vitamin E separately or together with vitamin C. We conclude that vitamin E separately or together with vitamin C suppressed cytogenetic injury and damage to some biochemical pathways of rat organs induced by AlCl 3 . Keywords: albino rats, aluminum chloride, blood indices, rat organs, vitamin E, vitamin C." @default.
• W2147946013 created "2016-06-24" @default.
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• W2147946013 date "2011-10-20" @default.
• W2147946013 modified "2023-09-27" @default.
• W2147946013 title "Determination of blood indices of albino rats treated with aluminum chloride and investigation of antioxidant effects of vitamin E and C" @default.
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• W2147946013 doi "https://doi.org/10.4314/ejb.v13i1.1" @default.
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