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• W2147998319 abstract "To whom correspondence should be addressed at: NS-LIJ Research Institute, 350 Community Drive, Room 125, Manhasset, NewYork 11030 USA. E-mail: sbenoff@nshs.eduThe term ‘varicocele’, which was coined by Curling in 1843(Noske and Weidner, 1999), refers to an abnormal dilation of thetesticular veins within the pampiniform plexus. Varicocele occurmore frequently on the left side (Riba, 1947), most probably dueto asymmetry of the internal spermatic veins resulting inalterations in biochemical properties (e.g. increased extensibilityin comparison with the right spermatic vein) (Lund et al., 1998).Varicocele was recognized and treated as early as the 1st centuryAD and, over the centuries, the condition was an importantexclusion criterion for military service (Noske and Weidner,1999). However, it was not until 1952 that the possibleassociation between the presence of a varicocele and humanmale subfertility was formally recognized. Such recognition wasderived from a single case report, of a man diagnosed withmaturation arrest by testis biopsy, in which bilateral varicoce-lectomy resulted in improved sperm count and pregnancy bycoitus (Tulloch, 1952). A flurry of reports followed, suggestingthat the incidence of varicocele was increased in subfertile men(Russell, 1954; Scott, 1958) and that improvement in semenparameters occurred after surgical intervention (Davidson, 1954;Tulloch, 1955; Young, 1956; Scott, 1961; Charny, 1962;MacLeod, 1965; Dubin and Hotchkiss, 1969).In current medical practice, impairment of semen parameterssuggests that a varicocele may be present. In particular, a decreasein sperm number, motility and morphologically normal sperma-tozoa with an increase in head abnormalities is most often found(MacLeod, 1965; Brown, 1976; Belker, 1981; Naftulin et al.,1991). This finding alone should provide sufficient impetus forfurther evaluation of the male. Of particular clinical importance isthat a significant number of men presenting with subfertility havemedical issues that would not have been diagnosed if an impairedsemen analysis had not led to further evaluation (Honig et al.,1994; Jarow, 1994). Several investigators have also presentedcompelling data suggesting that a varicocele causes a progressivedecline in fertility with upwards of 80% of men presenting withsecondary subfertility having a varicocele (Gorelick andGoldstein, 1993; Witt and Lipshultz, 1993). This decline isthought to be due to progressive testicular damage, as testicularmass and sperm counts in patients with varicocele decline withage (Lipshultz and Corriere, 1977). The occurrence of testiculardamage with varicocele has alternatively been attributed to: (i)increased scrotal (intratesticular) temperature; (ii) venous stasis;(iii) reduced oxygen tension, and/or (iv) toxic metabolites fromthe adrenals or kidney (Brown et al., 1967). To date, heat stressremains the favoured mechanism (Comhaire, 1991; Mieusset andBujan, 1995; Wright et al., 1997).Despite such findings, it is apparent that >85% of men withvaricocele are fertile (Sylora and Pryor, 1994). The same semenabnormalities are observed in fertile and infertile men withvaricocele (Nagao et al., 1986). Although varicocele repair canreduce testicular temperature (Agger, 1971; Yamaguchi et al.,1989; Wright et al., 1997), only about one half of the studies onthe effects of varicocele repair report a significant improvement inpregnancy rates after treatment, when compared with a control(no treatment) group. In the absence of molecular markers, whichdiscriminate between fertile and infertile men with varicocele,whether or not patient selection contributes to these disparatefindings is an open question. As will be seen from the contents ofthis mini symposium, varicocele remains a controversial topic,which is often the subject of heated debates between andrologistsand urologists, both about appropriate clinical management andabout the mechanisms producing infertility with varicocele. Thismini symposium was organized to address these issues.This mini symposium is divided into two parts: both temporallyand with regard to content. The first part, in this issue of HumanReproduction Update (Cozzolino and Lipschultz, 2001; Jarrow,2001; Kamischke and Nieschlag, 2001; Silber, 2001; Turner,2001) covers two main questions: firstly, does varicocele producean infertile state? and, secondly, does varicocele repair increasepregnancy rates? The second part of this mini symposium (to bepublished in a later issue of Human Reproduction Update)isdirected at the identification of varicocele-associated defects insperm function and the underlying pathophysiology of theinfertile state, including the role of ancillary factors." @default.
• W2147998319 created "2016-06-24" @default.
• W2147998319 creator A5060303583 @default.
• W2147998319 creator A5079616893 @default.
• W2147998319 date "2001-01-01" @default.
• W2147998319 modified "2023-10-16" @default.
• W2147998319 title "Varicocele and male infertility: Part I" @default.
• W2147998319 cites W105396583 @default.
• W2147998319 cites W136327257 @default.
• W2147998319 cites W140309301 @default.
• W2147998319 cites W144274639 @default.
• W2147998319 cites W1461300049 @default.
• W2147998319 cites W1508788792 @default.
• W2147998319 cites W1512522449 @default.
• W2147998319 cites W1522821981 @default.
• W2147998319 cites W1526060582 @default.
• W2147998319 cites W1570662951 @default.
• W2147998319 cites W169260193 @default.
• W2147998319 cites W1967477668 @default.
• W2147998319 cites W1969811094 @default.
• W2147998319 cites W1977907958 @default.
• W2147998319 cites W1984875801 @default.
• W2147998319 cites W1986354042 @default.
• W2147998319 cites W1991945474 @default.
• W2147998319 cites W1992099243 @default.
• W2147998319 cites W1994044319 @default.
• W2147998319 cites W1994744913 @default.
• W2147998319 cites W1995432948 @default.
• W2147998319 cites W1997656957 @default.
• W2147998319 cites W1999180950 @default.
• W2147998319 cites W2003069454 @default.
• W2147998319 cites W2005582298 @default.
• W2147998319 cites W2010096316 @default.
• W2147998319 cites W2018742933 @default.
• W2147998319 cites W2021235336 @default.
• W2147998319 cites W2021798302 @default.
• W2147998319 cites W2022276053 @default.
• W2147998319 cites W2028911727 @default.
• W2147998319 cites W2033409317 @default.
• W2147998319 cites W2035571868 @default.
• W2147998319 cites W203672653 @default.
• W2147998319 cites W2037009952 @default.
• W2147998319 cites W2038074463 @default.
• W2147998319 cites W2038584245 @default.
• W2147998319 cites W2042185966 @default.
• W2147998319 cites W2047920766 @default.
• W2147998319 cites W2048775430 @default.
• W2147998319 cites W204905818 @default.
• W2147998319 cites W2053145804 @default.
• W2147998319 cites W2065615172 @default.
• W2147998319 cites W2069307104 @default.
• W2147998319 cites W2071894619 @default.
• W2147998319 cites W2074557874 @default.
• W2147998319 cites W2077758009 @default.
• W2147998319 cites W2078837742 @default.
• W2147998319 cites W2080204825 @default.
• W2147998319 cites W2081193040 @default.
• W2147998319 cites W2082662940 @default.
• W2147998319 cites W2086004105 @default.
• W2147998319 cites W2086397190 @default.
• W2147998319 cites W2089806445 @default.
• W2147998319 cites W2090556046 @default.
• W2147998319 cites W2094051883 @default.
• W2147998319 cites W2096160039 @default.
• W2147998319 cites W2100237684 @default.
• W2147998319 cites W2109292794 @default.
• W2147998319 cites W2109896850 @default.
• W2147998319 cites W2110539375 @default.
• W2147998319 cites W2113423204 @default.
• W2147998319 cites W2116646023 @default.
• W2147998319 cites W2116649023 @default.
• W2147998319 cites W2118070093 @default.
• W2147998319 cites W2121290212 @default.
• W2147998319 cites W2123866259 @default.
• W2147998319 cites W2126742020 @default.
• W2147998319 cites W2128544336 @default.
• W2147998319 cites W2138101418 @default.
• W2147998319 cites W2140476020 @default.
• W2147998319 cites W2144073503 @default.
• W2147998319 cites W2145311718 @default.
• W2147998319 cites W2148065150 @default.
• W2147998319 cites W2155640221 @default.
• W2147998319 cites W2158046924 @default.
• W2147998319 cites W2161790107 @default.
• W2147998319 cites W2163662012 @default.
• W2147998319 cites W2166123311 @default.
• W2147998319 cites W2166479530 @default.
• W2147998319 cites W2178016243 @default.
• W2147998319 cites W2234171070 @default.
• W2147998319 cites W2240280269 @default.
• W2147998319 cites W2276698940 @default.
• W2147998319 cites W2276833138 @default.
• W2147998319 cites W2283531209 @default.
• W2147998319 cites W2291408201 @default.
• W2147998319 cites W2293320339 @default.
• W2147998319 cites W2296997329 @default.
• W2147998319 cites W2298426593 @default.
• W2147998319 cites W2395922985 @default.

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