FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148022015> ?p ?o ?g. }

• W2148022015 endingPage "238" @default.
• W2148022015 startingPage "225" @default.
• W2148022015 abstract "To investigate the therapeutic effect and potential mechanisms of the natural flavonoid quercetin-3-O-β-D-glucuronide (Q3GA) against lipid metabolism disorder in free fatty acid (FFA)-induced fatty liver in vivo and in vitro.Fat accumulation was documented by oil red O staining, and intracellular triglyceride levels were detected by triglyceride(TG) enzymatic assay. Flow cytometry and enzyme-linked immunoassay assay were performed to observe the effect of Q3GA on lipotoxicity and inflammation response of primary rat hepatocytes with FFA treatment. Administration with Q3GA at doses of 25 and 50 mg/kg from the fifth week during high fat diet (HFD) induced non-alcoholic fatty liver disease (NAFLD) model for 8 weeks. Expression of the genes involved in the lipogenesis and fatty acid β-oxidation were assayed by reverse transcription polymerase chain reaction.Q3GA reduced bodyweight gain, liver weight, liver index, dyslipidemia and hepatic TG level in a dose-dependant manner. In the FFA-overloaded primary rat hepatocytes, Q3GA decreased the fat overload and TG content, inhibited hepatocyte apoptosis and reduced inflammation cytokine expression. Importantly, the histopathological examination of liver showed that Q3GA could decrease hepatic lipid accumulation and liver injury. Besides, Q3GA decreased the expression of sterol regulatory element-binding protein-1c (SREBP-1c), fatty acid synthase and increased the expression of peroxisome proliferator-activated receptor-α (PPAR-α), carnitine palmitoyl-transferase 1 and medium-chain acyl-coenzyme A dehydrogenase in vivo and in vitro.The therapeutic effect of Q3GA on lipid metabolism disorder in FFA-induced fatty liver rats is partly due to downregulating SREBP-1c and upregulating PPAR-α-mediated metabolic pathways." @default.
• W2148022015 created "2016-06-24" @default.
• W2148022015 creator A5001348139 @default.
• W2148022015 creator A5018073672 @default.
• W2148022015 creator A5027835055 @default.
• W2148022015 creator A5044324691 @default.
• W2148022015 creator A5060491997 @default.
• W2148022015 creator A5066925708 @default.
• W2148022015 date "2015-09-02" @default.
• W2148022015 modified "2023-09-24" @default.
• W2148022015 title "Amelioration of free fatty acid‐induced fatty liver by quercetin‐3‐O‐β‐D‐glucuronide through modulation of peroxisome proliferator‐activated receptor‐alpha/sterol regulatory element‐binding protein‐1c signaling" @default.
• W2148022015 cites W1965014320 @default.
• W2148022015 cites W1967972402 @default.
• W2148022015 cites W1975610756 @default.
• W2148022015 cites W1981692260 @default.
• W2148022015 cites W1985046281 @default.
• W2148022015 cites W1985592156 @default.
• W2148022015 cites W1992269676 @default.
• W2148022015 cites W1997901667 @default.
• W2148022015 cites W1998143374 @default.
• W2148022015 cites W2007407160 @default.
• W2148022015 cites W2010340961 @default.
• W2148022015 cites W2013647172 @default.
• W2148022015 cites W2014052977 @default.
• W2148022015 cites W2014077252 @default.
• W2148022015 cites W2015643123 @default.
• W2148022015 cites W2017918116 @default.
• W2148022015 cites W2024851295 @default.
• W2148022015 cites W2025151193 @default.
• W2148022015 cites W2025321594 @default.
• W2148022015 cites W2027831465 @default.
• W2148022015 cites W2039472410 @default.
• W2148022015 cites W2039701037 @default.
• W2148022015 cites W2040552715 @default.
• W2148022015 cites W2045515542 @default.
• W2148022015 cites W2046127153 @default.
• W2148022015 cites W2057896729 @default.
• W2148022015 cites W2059388722 @default.
• W2148022015 cites W2065257841 @default.
• W2148022015 cites W2067740038 @default.
• W2148022015 cites W2072362233 @default.
• W2148022015 cites W2074203821 @default.
• W2148022015 cites W2081536949 @default.
• W2148022015 cites W2091330563 @default.
• W2148022015 cites W2096752988 @default.
• W2148022015 cites W2102106861 @default.
• W2148022015 cites W2102224211 @default.
• W2148022015 cites W2103577793 @default.
• W2148022015 cites W2108971238 @default.
• W2148022015 cites W2112317454 @default.
• W2148022015 cites W2115901158 @default.
• W2148022015 cites W2122728795 @default.
• W2148022015 cites W2127178720 @default.
• W2148022015 cites W2128730052 @default.
• W2148022015 cites W2134292324 @default.
• W2148022015 cites W2145297882 @default.
• W2148022015 cites W2150718942 @default.
• W2148022015 cites W2164898770 @default.
• W2148022015 cites W2168420558 @default.
• W2148022015 cites W2170728971 @default.
• W2148022015 cites W2183722547 @default.
• W2148022015 doi "https://doi.org/10.1111/hepr.12557" @default.
• W2148022015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26190035" @default.
• W2148022015 hasPublicationYear "2015" @default.
• W2148022015 type Work @default.
• W2148022015 sameAs 2148022015 @default.
• W2148022015 citedByCount "24" @default.
• W2148022015 countsByYear W21480220152016 @default.
• W2148022015 countsByYear W21480220152017 @default.
• W2148022015 countsByYear W21480220152018 @default.
• W2148022015 countsByYear W21480220152019 @default.
• W2148022015 countsByYear W21480220152020 @default.
• W2148022015 countsByYear W21480220152021 @default.
• W2148022015 countsByYear W21480220152022 @default.
• W2148022015 countsByYear W21480220152023 @default.
• W2148022015 crossrefType "journal-article" @default.
• W2148022015 hasAuthorship W2148022015A5001348139 @default.
• W2148022015 hasAuthorship W2148022015A5018073672 @default.
• W2148022015 hasAuthorship W2148022015A5027835055 @default.
• W2148022015 hasAuthorship W2148022015A5044324691 @default.
• W2148022015 hasAuthorship W2148022015A5060491997 @default.
• W2148022015 hasAuthorship W2148022015A5066925708 @default.
• W2148022015 hasConcept C126322002 @default.
• W2148022015 hasConcept C134018914 @default.
• W2148022015 hasConcept C141359234 @default.
• W2148022015 hasConcept C170493617 @default.
• W2148022015 hasConcept C185592680 @default.
• W2148022015 hasConcept C187345961 @default.
• W2148022015 hasConcept C2777391703 @default.
• W2148022015 hasConcept C2778163477 @default.
• W2148022015 hasConcept C2778435403 @default.
• W2148022015 hasConcept C2778772119 @default.
• W2148022015 hasConcept C2778913445 @default.
• W2148022015 hasConcept C2779134260 @default.
• W2148022015 hasConcept C2779306644 @default.
• W2148022015 hasConcept C44353895 @default.
• W2148022015 hasConcept C4733338 @default.
• W2148022015 hasConcept C48289651 @default.

• next