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• W2148045277 endingPage "202" @default.
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• W2148045277 abstract "Erythrocyte injury such as osmotic shock, oxidative stress or energy depletion stimulates the formation of prostaglandin E2 through activation of cyclooxygenase which in turn activates a Ca2+ permeable cation channel. Increasing cytosolic Ca2+ concentrations activate Ca2+ sensitive K+ channels leading to hyperpolarization, subsequent loss of KCl and (further) cell shrinkage. Ca2+ further stimulates a scramblase shifting phosphatidylserine from the inner to the outer cell membrane. The scramblase is sensitized for the effects of Ca2+ by ceramide which is formed by a sphingomyelinase following several stressors including osmotic shock. The sphingomyelinase is activated by platelet activating factor PAF which is released by activation of phospholipase A2. Phosphatidylserine at the erythrocyte surface is recognised by macrophages which engulf and degrade the affected cells. Moreover, phosphatidylserine exposing erythrocytes may adhere to the vascular wall and thus interfere with microcirculation. Erythrocyte shrinkage and phosphatidylserine exposure (‘eryptosis’) mimic features of apoptosis in nucleated cells which however, involves several mechanisms lacking in erythrocytes. In kidney medulla, exposure time is usually too short to induce eryptosis despite high osmolarity. Beyond that high Cl- concentrations inhibit the cation channel and high urea concentrations the sphingomyelinase. Eryptosis is inhibited by erythropoietin which thus extends the life span of circulating erythrocytes. Several conditions trigger premature eryptosis thus favouring the development of anemia. On the other hand, eryptosis may be a mechanism of defective erythrocytes to escape hemolysis. Beyond their significance for erythrocyte survival and death the mechanisms involved in ‘eryptosis’ may similarly contribute to apoptosis of nucleated cells." @default.
• W2148045277 created "2016-06-24" @default.
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• W2148045277 date "2005-01-01" @default.
• W2148045277 modified "2023-10-15" @default.
• W2148045277 title "Mechanisms of Suicidal Erythrocyte Death" @default.
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• W2148045277 cites W155057202 @default.
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• W2148045277 cites W1969886439 @default.
• W2148045277 cites W1972748726 @default.
• W2148045277 cites W1976018125 @default.
• W2148045277 cites W1976466808 @default.
• W2148045277 cites W1981541729 @default.
• W2148045277 cites W1983418648 @default.
• W2148045277 cites W1985040456 @default.
• W2148045277 cites W1985345682 @default.
• W2148045277 cites W1991382760 @default.
• W2148045277 cites W1991870376 @default.
• W2148045277 cites W1994224570 @default.
• W2148045277 cites W1995870256 @default.
• W2148045277 cites W1996179257 @default.
• W2148045277 cites W1997519809 @default.
• W2148045277 cites W2003505368 @default.
• W2148045277 cites W2003693275 @default.
• W2148045277 cites W2008479667 @default.
• W2148045277 cites W2010193398 @default.
• W2148045277 cites W2015717266 @default.
• W2148045277 cites W2015807826 @default.
• W2148045277 cites W2016558309 @default.
• W2148045277 cites W2019107970 @default.
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• W2148045277 cites W2022182129 @default.
• W2148045277 cites W2026875866 @default.
• W2148045277 cites W2027851046 @default.
• W2148045277 cites W2030570585 @default.
• W2148045277 cites W2033982017 @default.
• W2148045277 cites W2035320088 @default.
• W2148045277 cites W2035341414 @default.
• W2148045277 cites W2038819783 @default.
• W2148045277 cites W2039506763 @default.
• W2148045277 cites W2039659095 @default.
• W2148045277 cites W2042948104 @default.
• W2148045277 cites W2043994824 @default.
• W2148045277 cites W2050036363 @default.
• W2148045277 cites W2052726190 @default.
• W2148045277 cites W2054934343 @default.
• W2148045277 cites W2065641335 @default.
• W2148045277 cites W2071085094 @default.
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• W2148045277 cites W2139953109 @default.
• W2148045277 cites W2148394321 @default.
• W2148045277 cites W2153422264 @default.
• W2148045277 cites W2154766878 @default.
• W2148045277 cites W2155325845 @default.
• W2148045277 cites W2155556672 @default.
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• W2148045277 cites W2168379147 @default.
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• W2148045277 cites W2336116827 @default.
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• W2148045277 doi "https://doi.org/10.1159/000086406" @default.
• W2148045277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15956782" @default.
• W2148045277 hasPublicationYear "2005" @default.
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