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• W2148045809 endingPage "1819" @default.
• W2148045809 startingPage "1811" @default.
• W2148045809 abstract "The neuropeptide GnRH is a central regulator of mammalian reproductive function produced by a dispersed population of hypothalamic neurosecretory neurons. The principal action of GnRH is to regulate release of the gonadotropins, LH and FSH, by the gonadotrope cells of the anterior pituitary. Using a cultured cell model of mouse pituitary gonadotrope cells, alphaT3-1 cells, we present evidence that GnRH stimulation of alphaT3-1 cells results in an increase in cap-dependent mRNA translation. GnRH receptor activation results in increased protein synthesis through a regulator of mRNA translation initiation, eukaryotic translation initiation factor 4E-binding protein, known as 4EBP or PHAS (protein, heat, and acid stable). Although the GnRH receptor is a member of the rhodopsin-like family of G protein-linked receptors, we show that activation of translation proceeds through a signaling pathway previously described for receptor tyrosine kinases. Stimulation of translation by GnRH is protein kinase C and Ras dependent and sensitive to rapamycin. Furthermore, GnRH may also regulate the cell cycle in alphaT3-1 cells. The activation of a signaling pathway that regulates both protein synthesis and cell cycle suggests that GnRH may have a significant role in the maintenance of the pituitary gonadotrope population in addition to directing the release of gonadotropins." @default.
• W2148045809 created "2016-06-24" @default.
• W2148045809 creator A5002236629 @default.
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• W2148045809 date "2000-11-01" @default.
• W2148045809 modified "2023-10-17" @default.
• W2148045809 title "Activation of Translation in Pituitary Gonadotrope Cells by Gonadotropin-Releasing Hormone" @default.
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• W2148045809 doi "https://doi.org/10.1210/mend.14.11.0550" @default.
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