Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148046607> ?p ?o ?g. }
- W2148046607 endingPage "7546" @default.
- W2148046607 startingPage "7540" @default.
- W2148046607 abstract "Abstract Purpose: Transforming growth factors (TGFs) have pleiotropic biological effects on tumor cells and their environment. In multiple myeloma (MM), we have reported that bone marrow stromal cells (BMSCs) from MM patients produce more TGF-β1 than BMSCs from healthy donors, which in turn induces interleukin (IL)-6 secretion. We show here that the TGF-β receptor I kinase inhibitor SD-208 significantly decreases secretion of both IL-6 and vascular endothelial growth factor (VEGF) from BMSCs, as well as tumor cell growth triggered by MM cell adhesion to BMSCs. Experimental Design: Cytokine production and MM cell proliferation triggered by TGF-β1 or adhesion to BMSCs were examined in the presence or absence of SD-208. Effects of SD-208 on TGF-β1–induced signaling pathways triggering IL-6 and VEGF transcription in BMSCs were also delineated. Results: SD-208 significantly inhibits not only transcription but also secretion of both IL-6 and VEGF from BMSCs triggered by either TGF-β1 or adhesion of MM cells to BMSCs. Moreover, SD-208 decreased tumor cell growth triggered by MM cell adhesion to BMSCs. SD-208 works, at least in part, by blocking TGF-β1–triggered nuclear accumulation of Smad2/3 and hypoxia-inducible factor 1α, as well as related production of IL-6 and VEGF, respectively. Conclusions: These studies indicate that SD-208 inhibits production of cytokines mediating MM cell growth, survival, drug resistance, and migration in the BM milieu, thereby providing the preclinical rationale for clinical evaluation of SD-208 to improve patient outcome in MM." @default.
- W2148046607 created "2016-06-24" @default.
- W2148046607 creator A5003058860 @default.
- W2148046607 creator A5006765393 @default.
- W2148046607 creator A5007023688 @default.
- W2148046607 creator A5010152323 @default.
- W2148046607 creator A5013437544 @default.
- W2148046607 creator A5032464400 @default.
- W2148046607 creator A5033718619 @default.
- W2148046607 creator A5043526996 @default.
- W2148046607 creator A5045095062 @default.
- W2148046607 creator A5059167270 @default.
- W2148046607 creator A5078030039 @default.
- W2148046607 creator A5078691986 @default.
- W2148046607 creator A5080902020 @default.
- W2148046607 creator A5091207345 @default.
- W2148046607 date "2004-11-15" @default.
- W2148046607 modified "2023-10-18" @default.
- W2148046607 title "Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment" @default.
- W2148046607 cites W1528751727 @default.
- W2148046607 cites W1549837901 @default.
- W2148046607 cites W1565561072 @default.
- W2148046607 cites W1568956696 @default.
- W2148046607 cites W1578283200 @default.
- W2148046607 cites W1580184585 @default.
- W2148046607 cites W1587849076 @default.
- W2148046607 cites W1798928306 @default.
- W2148046607 cites W1828227463 @default.
- W2148046607 cites W1977348505 @default.
- W2148046607 cites W1985147506 @default.
- W2148046607 cites W1995041534 @default.
- W2148046607 cites W1995194065 @default.
- W2148046607 cites W2001012146 @default.
- W2148046607 cites W2007998678 @default.
- W2148046607 cites W2023279835 @default.
- W2148046607 cites W2035653659 @default.
- W2148046607 cites W2040252279 @default.
- W2148046607 cites W2059873406 @default.
- W2148046607 cites W2069472458 @default.
- W2148046607 cites W2083426483 @default.
- W2148046607 cites W2108235071 @default.
- W2148046607 cites W2113101033 @default.
- W2148046607 cites W2133986577 @default.
- W2148046607 cites W2144531125 @default.
- W2148046607 cites W2154374454 @default.
- W2148046607 cites W2303045765 @default.
- W2148046607 cites W4232371648 @default.
- W2148046607 cites W4233115378 @default.
- W2148046607 doi "https://doi.org/10.1158/1078-0432.ccr-04-0632" @default.
- W2148046607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15569984" @default.
- W2148046607 hasPublicationYear "2004" @default.
- W2148046607 type Work @default.
- W2148046607 sameAs 2148046607 @default.
- W2148046607 citedByCount "104" @default.
- W2148046607 countsByYear W21480466072012 @default.
- W2148046607 countsByYear W21480466072013 @default.
- W2148046607 countsByYear W21480466072014 @default.
- W2148046607 countsByYear W21480466072016 @default.
- W2148046607 countsByYear W21480466072017 @default.
- W2148046607 countsByYear W21480466072018 @default.
- W2148046607 countsByYear W21480466072019 @default.
- W2148046607 countsByYear W21480466072020 @default.
- W2148046607 countsByYear W21480466072021 @default.
- W2148046607 countsByYear W21480466072022 @default.
- W2148046607 countsByYear W21480466072023 @default.
- W2148046607 crossrefType "journal-article" @default.
- W2148046607 hasAuthorship W2148046607A5003058860 @default.
- W2148046607 hasAuthorship W2148046607A5006765393 @default.
- W2148046607 hasAuthorship W2148046607A5007023688 @default.
- W2148046607 hasAuthorship W2148046607A5010152323 @default.
- W2148046607 hasAuthorship W2148046607A5013437544 @default.
- W2148046607 hasAuthorship W2148046607A5032464400 @default.
- W2148046607 hasAuthorship W2148046607A5033718619 @default.
- W2148046607 hasAuthorship W2148046607A5043526996 @default.
- W2148046607 hasAuthorship W2148046607A5045095062 @default.
- W2148046607 hasAuthorship W2148046607A5059167270 @default.
- W2148046607 hasAuthorship W2148046607A5078030039 @default.
- W2148046607 hasAuthorship W2148046607A5078691986 @default.
- W2148046607 hasAuthorship W2148046607A5080902020 @default.
- W2148046607 hasAuthorship W2148046607A5091207345 @default.
- W2148046607 hasBestOaLocation W21480466071 @default.
- W2148046607 hasConcept C118131993 @default.
- W2148046607 hasConcept C126322002 @default.
- W2148046607 hasConcept C167734588 @default.
- W2148046607 hasConcept C16930146 @default.
- W2148046607 hasConcept C170493617 @default.
- W2148046607 hasConcept C185592680 @default.
- W2148046607 hasConcept C203014093 @default.
- W2148046607 hasConcept C2775960820 @default.
- W2148046607 hasConcept C2777025900 @default.
- W2148046607 hasConcept C2778690821 @default.
- W2148046607 hasConcept C2780007613 @default.
- W2148046607 hasConcept C502942594 @default.
- W2148046607 hasConcept C55493867 @default.
- W2148046607 hasConcept C62112901 @default.
- W2148046607 hasConcept C71924100 @default.
- W2148046607 hasConcept C86803240 @default.
- W2148046607 hasConcept C95444343 @default.