FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148049102> ?p ?o ?g. }

• W2148049102 endingPage "5114" @default.
• W2148049102 startingPage "5104" @default.
• W2148049102 abstract "Novel object recognition (NOR) in rodents is analogous in some ways to human declarative (episodic) memory, one of the seven cognitive domains which are abnormal in schizophrenia. Cognitive impairment in schizophrenia (CIS) accounts for the largest proportion of the poor functional outcomes in this complex syndrome, with psychosis and negative symptoms accounting for much of the rest. Current atypical antipsychotic drugs (APDs) e.g. amisulpride, aripiprazole, clozapine, lurasidone, olanzapine and risperidone, and typical APDs as well, significantly improve some, but not all aspects of CIS, including declarative memory, but not in all patients, and rarely restore normal function. Thus, finding new ways to prevent or treat CIS is a major goal of current schizophrenia research, with animal models as an essential tool. NOR in rodents is valuable in this regard because of its relationship to declarative memory, the extensive knowledge of its underlying circuitry, and the ease and reliability of assessment. Sub-chronic administration of an N-methyl-Daspartate receptor (NMDAR) non-competitive antagonist, e.g. phencyclidine (PCP), dizocilpine (MK-801) or ketamine, is a favored means to study NOR as a model of CIS, because it produces deficient glutamatergic and GABAergic function, both of which have been implicated in the development of CIS. Transgenic mice and anti-cholinergic-induced deficits in NOR have received less attention. We review here NOR studies in rodents that bear upon CIS, including the evidence that atypical, but not typical APDs, as well as specific ligands, e.g. 5-HT1A partial agonists, 5-HT7 antagonists, D1 agonists, among others, can restore NOR following sub-chronic NMDAR antagonist treatment, and can also prevent the impairment in NOR produced by sub-chronic NMDAR antagonists. We discuss how well these findings translate to the bedside. Keywords: NOR, PCP, schizophrenia, cognition, declarative memory, 5-HT1A, 5-HT7, lurasidone." @default.
• W2148049102 created "2016-06-24" @default.
• W2148049102 creator A5004211130 @default.
• W2148049102 creator A5044110984 @default.
• W2148049102 creator A5060651833 @default.
• W2148049102 creator A5060728653 @default.
• W2148049102 creator A5079864851 @default.
• W2148049102 date "2014-08-31" @default.
• W2148049102 modified "2023-10-08" @default.
• W2148049102 title "The Novel Object Recognition Test in Rodents in Relation to Cognitive Impairment in Schizophrenia" @default.
• W2148049102 cites W1497084816 @default.
• W2148049102 cites W1526674447 @default.
• W2148049102 cites W1534639541 @default.
• W2148049102 cites W1534720449 @default.
• W2148049102 cites W1582254691 @default.
• W2148049102 cites W1600050350 @default.
• W2148049102 cites W1616286551 @default.
• W2148049102 cites W162017141 @default.
• W2148049102 cites W1905429706 @default.
• W2148049102 cites W1964815610 @default.
• W2148049102 cites W1970331308 @default.
• W2148049102 cites W1971184880 @default.
• W2148049102 cites W1973854311 @default.
• W2148049102 cites W1977106703 @default.
• W2148049102 cites W1978598728 @default.
• W2148049102 cites W1979325779 @default.
• W2148049102 cites W1980628262 @default.
• W2148049102 cites W1980944036 @default.
• W2148049102 cites W1981368038 @default.
• W2148049102 cites W1982094365 @default.
• W2148049102 cites W1982487023 @default.
• W2148049102 cites W1983245960 @default.
• W2148049102 cites W1986336245 @default.
• W2148049102 cites W1986782185 @default.
• W2148049102 cites W1987086913 @default.
• W2148049102 cites W1989397869 @default.
• W2148049102 cites W1989893823 @default.
• W2148049102 cites W1992281684 @default.
• W2148049102 cites W1993234897 @default.
• W2148049102 cites W1993337719 @default.
• W2148049102 cites W1994153884 @default.
• W2148049102 cites W1994801355 @default.
• W2148049102 cites W1995519493 @default.
• W2148049102 cites W1997048564 @default.
• W2148049102 cites W1997074109 @default.
• W2148049102 cites W1999300768 @default.
• W2148049102 cites W2002178715 @default.
• W2148049102 cites W2008964179 @default.
• W2148049102 cites W2009011613 @default.
• W2148049102 cites W2009052798 @default.
• W2148049102 cites W2009309964 @default.
• W2148049102 cites W2010543372 @default.
• W2148049102 cites W2011182878 @default.
• W2148049102 cites W2012690921 @default.
• W2148049102 cites W2015472050 @default.
• W2148049102 cites W2017998586 @default.
• W2148049102 cites W2019167264 @default.
• W2148049102 cites W2020326582 @default.
• W2148049102 cites W2021224600 @default.
• W2148049102 cites W2021489201 @default.
• W2148049102 cites W2022765281 @default.
• W2148049102 cites W2025714319 @default.
• W2148049102 cites W2026198362 @default.
• W2148049102 cites W2028884770 @default.
• W2148049102 cites W2029616874 @default.
• W2148049102 cites W2031702230 @default.
• W2148049102 cites W2034823208 @default.
• W2148049102 cites W2034932119 @default.
• W2148049102 cites W2035601252 @default.
• W2148049102 cites W2036521491 @default.
• W2148049102 cites W2037746448 @default.
• W2148049102 cites W2041454408 @default.
• W2148049102 cites W2043564452 @default.
• W2148049102 cites W2043611111 @default.
• W2148049102 cites W2046411639 @default.
• W2148049102 cites W2049984249 @default.
• W2148049102 cites W2052262915 @default.
• W2148049102 cites W2053701494 @default.
• W2148049102 cites W2054002536 @default.
• W2148049102 cites W2055996490 @default.
• W2148049102 cites W2058889376 @default.
• W2148049102 cites W2062636920 @default.
• W2148049102 cites W2062949684 @default.
• W2148049102 cites W2064446575 @default.
• W2148049102 cites W2069974855 @default.
• W2148049102 cites W2073733294 @default.
• W2148049102 cites W2073935709 @default.
• W2148049102 cites W2075600753 @default.
• W2148049102 cites W2075955141 @default.
• W2148049102 cites W2076385557 @default.
• W2148049102 cites W2085360366 @default.
• W2148049102 cites W2088403966 @default.
• W2148049102 cites W2089412776 @default.
• W2148049102 cites W2090246683 @default.
• W2148049102 cites W2091973569 @default.
• W2148049102 cites W2095043290 @default.
• W2148049102 cites W2105848971 @default.
• W2148049102 cites W2106352416 @default.

• next