Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148057127> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2148057127 endingPage "566" @default.
- W2148057127 startingPage "555" @default.
- W2148057127 abstract "1. The intracellular sodium activity (alpha Na1), contraction and membrane current were recorded simultaneously in voltage-clamped guinea-pig ventricular myocytes. 2. Increasing the frequency (from 0.5 to 3 Hz) of voltage clamp pulses to 0 mV from a holding potential of -80 mV led to an increase in both alpha Na1 and contraction. The rate-dependent increase in contraction was reduced by 25 microM tetrodotoxin (TTX) and abolished with a holding potential of -40 mV. There was no rate-dependent rise in alpha Na1 with a holding potential of -40 mV. These results suggest an important role for alpha Na1 and in particular Na+ influx via Na+ channels during rate-dependent changes in contraction. 3. After an increase in frequency from 0.5 to 3 Hz, membrane current at the end of voltage clamp pulses became progressively more outward and the tail current upon at repolarization became progressively more inward compared with those recorded at 0.5 Hz. TTX reduced the magnitude of both the outward and inward rate-dependent shifts of current. 4. The addition of extracellular CsCl blocked the inward rectifier potassium current (IK.1) and the delayed rectifier (IK), but did not change the rate-dependent shift in current. 5. The difference between current-voltage relationships at 0.5 and 3 Hz showed that the rate-dependent outward shift of current at the end of voltage clamp pulses was small at potentials negative to -20 mV, was larger at more positive potentials and was reduced by TTX at most potentials. The TTX-sensitive component reversed at -47 mV. 6. These results are consistent with a net increase in outward Na(+)-Ca2+ exchange current during a voltage clamp pulse in response to the rise of alpha Na1. The increase in outward current (resulting from either enhanced Ca2+ influx or reduced Ca2+ efflux) will augment the Ca2+ load of the cell and contribute to the rate-dependent increase in contraction." @default.
- W2148057127 created "2016-06-24" @default.
- W2148057127 creator A5052719068 @default.
- W2148057127 creator A5089093335 @default.
- W2148057127 date "1995-02-01" @default.
- W2148057127 modified "2023-09-30" @default.
- W2148057127 title "The role of the Na(+)-Ca2+ exchanger in the rate-dependent increase in contraction in guinea-pig ventricular myocytes." @default.
- W2148057127 cites W1595593492 @default.
- W2148057127 cites W1964233954 @default.
- W2148057127 cites W1968652458 @default.
- W2148057127 cites W2011920501 @default.
- W2148057127 cites W2012788446 @default.
- W2148057127 cites W2013277826 @default.
- W2148057127 cites W2016295863 @default.
- W2148057127 cites W2020914291 @default.
- W2148057127 cites W2020927690 @default.
- W2148057127 cites W2029193464 @default.
- W2148057127 cites W2064948391 @default.
- W2148057127 cites W2069198907 @default.
- W2148057127 cites W2087696627 @default.
- W2148057127 cites W2092817569 @default.
- W2148057127 cites W2095063636 @default.
- W2148057127 cites W2099808541 @default.
- W2148057127 cites W2102878961 @default.
- W2148057127 cites W2116275634 @default.
- W2148057127 cites W2121270320 @default.
- W2148057127 cites W2156338544 @default.
- W2148057127 cites W2156847869 @default.
- W2148057127 cites W2430068122 @default.
- W2148057127 doi "https://doi.org/10.1113/jphysiol.1995.sp020539" @default.
- W2148057127 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1157781" @default.
- W2148057127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7738848" @default.
- W2148057127 hasPublicationYear "1995" @default.
- W2148057127 type Work @default.
- W2148057127 sameAs 2148057127 @default.
- W2148057127 citedByCount "35" @default.
- W2148057127 countsByYear W21480571272012 @default.
- W2148057127 countsByYear W21480571272013 @default.
- W2148057127 countsByYear W21480571272015 @default.
- W2148057127 countsByYear W21480571272016 @default.
- W2148057127 countsByYear W21480571272020 @default.
- W2148057127 countsByYear W21480571272021 @default.
- W2148057127 countsByYear W21480571272023 @default.
- W2148057127 crossrefType "journal-article" @default.
- W2148057127 hasAuthorship W2148057127A5052719068 @default.
- W2148057127 hasAuthorship W2148057127A5089093335 @default.
- W2148057127 hasBestOaLocation W21480571272 @default.
- W2148057127 hasConcept C100837961 @default.
- W2148057127 hasConcept C12554922 @default.
- W2148057127 hasConcept C126322002 @default.
- W2148057127 hasConcept C146403970 @default.
- W2148057127 hasConcept C147944092 @default.
- W2148057127 hasConcept C163415756 @default.
- W2148057127 hasConcept C181911157 @default.
- W2148057127 hasConcept C185263204 @default.
- W2148057127 hasConcept C185592680 @default.
- W2148057127 hasConcept C207200792 @default.
- W2148057127 hasConcept C2776741303 @default.
- W2148057127 hasConcept C2778815084 @default.
- W2148057127 hasConcept C71924100 @default.
- W2148057127 hasConcept C86803240 @default.
- W2148057127 hasConceptScore W2148057127C100837961 @default.
- W2148057127 hasConceptScore W2148057127C12554922 @default.
- W2148057127 hasConceptScore W2148057127C126322002 @default.
- W2148057127 hasConceptScore W2148057127C146403970 @default.
- W2148057127 hasConceptScore W2148057127C147944092 @default.
- W2148057127 hasConceptScore W2148057127C163415756 @default.
- W2148057127 hasConceptScore W2148057127C181911157 @default.
- W2148057127 hasConceptScore W2148057127C185263204 @default.
- W2148057127 hasConceptScore W2148057127C185592680 @default.
- W2148057127 hasConceptScore W2148057127C207200792 @default.
- W2148057127 hasConceptScore W2148057127C2776741303 @default.
- W2148057127 hasConceptScore W2148057127C2778815084 @default.
- W2148057127 hasConceptScore W2148057127C71924100 @default.
- W2148057127 hasConceptScore W2148057127C86803240 @default.
- W2148057127 hasIssue "3" @default.
- W2148057127 hasLocation W21480571271 @default.
- W2148057127 hasLocation W21480571272 @default.
- W2148057127 hasLocation W21480571273 @default.
- W2148057127 hasOpenAccess W2148057127 @default.
- W2148057127 hasPrimaryLocation W21480571271 @default.
- W2148057127 hasRelatedWork W1977151728 @default.
- W2148057127 hasRelatedWork W2055830121 @default.
- W2148057127 hasRelatedWork W2170957940 @default.
- W2148057127 hasRelatedWork W2206054962 @default.
- W2148057127 hasRelatedWork W2288331821 @default.
- W2148057127 hasRelatedWork W2324387369 @default.
- W2148057127 hasRelatedWork W2410720736 @default.
- W2148057127 hasRelatedWork W2417237198 @default.
- W2148057127 hasRelatedWork W4253911545 @default.
- W2148057127 hasRelatedWork W1975131962 @default.
- W2148057127 hasVolume "482" @default.
- W2148057127 isParatext "false" @default.
- W2148057127 isRetracted "false" @default.
- W2148057127 magId "2148057127" @default.
- W2148057127 workType "article" @default.