FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148084889> ?p ?o ?g. }

• W2148084889 endingPage "1337" @default.
• W2148084889 startingPage "1321" @default.
• W2148084889 abstract "Histone modifications, such as methylation and demethylation, are crucial mechanisms altering chromatin structure and gene expression. Recent biochemical and molecular studies have uncovered a group of histone demethylases called Jumonji C (JmjC) domain proteins. However, their evolutionary history and patterns have not been examined systematically. Here, we report extensive analyses of eukaryotic JmjC genes and define 14 subfamilies, including the Lysine-Specific Demethylase3 (KDM3), KDM5, JMJD6, Putative-Lysine-Specific Demethylase11 (PKDM11), and PKDM13 subfamilies, shared by plants, animals, and fungi. Other subfamilies are detected in plants and animals but not in fungi (PKDM12) or in animals and fungi but not in plants (KDM2 and KDM4). PKDM7, PKDM8, and PKDM9 are plant-specific groups, whereas Jumonji, AT-Rich Interactive Domain2, KDM6, and PKDM10 are animal specific. In addition to known domains, most subfamilies have characteristic conserved amino acid motifs. Whole-genome duplication (WGD) was likely an important mechanism for JmjC duplications, with four pairs from an angiosperm-wide WGD and others from subsequent WGDs. Vertebrates also experienced JmjC duplications associated with the vertebrate ancestral WGDs, with additional mammalian paralogs from tandem duplication and possible transposition. The sequences of paralogs have diverged in both known functional domains and other regions, showing evidence of selection pressure. The increases of JmjC copy number and the divergences in sequence and expression might have contributed to the divergent functions of JmjC genes, allowing the angiosperms and vertebrates to adapt to a great number of ecological niches and contributing to their evolutionary successes." @default.
• W2148084889 created "2016-06-24" @default.
• W2148084889 creator A5015555447 @default.
• W2148084889 creator A5019887722 @default.
• W2148084889 creator A5029214336 @default.
• W2148084889 creator A5088959897 @default.
• W2148084889 date "2015-06-09" @default.
• W2148084889 modified "2023-10-06" @default.
• W2148084889 title "Expansion and Functional Divergence of Jumonji C-Containing Histone Demethylases: Significance of Duplications in Ancestral Angiosperms and Vertebrates" @default.
• W2148084889 cites W102891818 @default.
• W2148084889 cites W1592870802 @default.
• W2148084889 cites W1671731419 @default.
• W2148084889 cites W1857141584 @default.
• W2148084889 cites W1976702683 @default.
• W2148084889 cites W1979826254 @default.
• W2148084889 cites W1981259598 @default.
• W2148084889 cites W1981301360 @default.
• W2148084889 cites W1981452104 @default.
• W2148084889 cites W1982409009 @default.
• W2148084889 cites W1985180051 @default.
• W2148084889 cites W1993053938 @default.
• W2148084889 cites W1994145712 @default.
• W2148084889 cites W1996655258 @default.
• W2148084889 cites W1997796525 @default.
• W2148084889 cites W1998918762 @default.
• W2148084889 cites W2001374342 @default.
• W2148084889 cites W2002698073 @default.
• W2148084889 cites W2010006632 @default.
• W2148084889 cites W2011005775 @default.
• W2148084889 cites W2012829695 @default.
• W2148084889 cites W2015132841 @default.
• W2148084889 cites W2020495286 @default.
• W2148084889 cites W2030734038 @default.
• W2148084889 cites W2034882046 @default.
• W2148084889 cites W2037993016 @default.
• W2148084889 cites W2039995816 @default.
• W2148084889 cites W2041389660 @default.
• W2148084889 cites W2043856402 @default.
• W2148084889 cites W2046269809 @default.
• W2148084889 cites W2047405437 @default.
• W2148084889 cites W2049608531 @default.
• W2148084889 cites W2052002049 @default.
• W2148084889 cites W2052708113 @default.
• W2148084889 cites W2054643318 @default.
• W2148084889 cites W2055043387 @default.
• W2148084889 cites W2058378183 @default.
• W2148084889 cites W2062237303 @default.
• W2148084889 cites W2065064903 @default.
• W2148084889 cites W2067121492 @default.
• W2148084889 cites W2067958295 @default.
• W2148084889 cites W2068854670 @default.
• W2148084889 cites W2079294785 @default.
• W2148084889 cites W2080326437 @default.
• W2148084889 cites W2082694471 @default.
• W2148084889 cites W2085967823 @default.
• W2148084889 cites W2088998472 @default.
• W2148084889 cites W2092414509 @default.
• W2148084889 cites W2097842908 @default.
• W2148084889 cites W2099000855 @default.
• W2148084889 cites W2099035207 @default.
• W2148084889 cites W2099946731 @default.
• W2148084889 cites W2100506137 @default.
• W2148084889 cites W2100541589 @default.
• W2148084889 cites W2100849967 @default.
• W2148084889 cites W2102793650 @default.
• W2148084889 cites W2103546861 @default.
• W2148084889 cites W2105329815 @default.
• W2148084889 cites W2106208020 @default.
• W2148084889 cites W2109183032 @default.
• W2148084889 cites W2120772351 @default.
• W2148084889 cites W2123073741 @default.
• W2148084889 cites W2132632499 @default.
• W2148084889 cites W2132926880 @default.
• W2148084889 cites W2144654387 @default.
• W2148084889 cites W2144792857 @default.
• W2148084889 cites W2145561139 @default.
• W2148084889 cites W2146058063 @default.
• W2148084889 cites W2147526198 @default.
• W2148084889 cites W2149531995 @default.
• W2148084889 cites W2150413484 @default.
• W2148084889 cites W2151831732 @default.
• W2148084889 cites W2152876917 @default.
• W2148084889 cites W2154382308 @default.
• W2148084889 cites W2155854467 @default.
• W2148084889 cites W2157882076 @default.
• W2148084889 cites W2159664363 @default.
• W2148084889 cites W2167078504 @default.
• W2148084889 cites W2168696662 @default.
• W2148084889 cites W2169150541 @default.
• W2148084889 cites W2169830295 @default.
• W2148084889 cites W2170145663 @default.
• W2148084889 cites W2172085202 @default.
• W2148084889 cites W4212766227 @default.
• W2148084889 doi "https://doi.org/10.1104/pp.15.00520" @default.
• W2148084889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4528752" @default.
• W2148084889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26059336" @default.
• W2148084889 hasPublicationYear "2015" @default.
• W2148084889 type Work @default.

• next