FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148099555> ?p ?o ?g. }

• W2148099555 endingPage "3358" @default.
• W2148099555 startingPage "3350" @default.
• W2148099555 abstract "Staphylococcus aureus is a leading cause of human bacterial infection, causing a wide spectrum of disease ranging from skin and soft tissue infections to life-threatening pneumonia and sepsis. S. aureus toxins play an essential role in disease pathogenesis, contributing to both immunomodulation and host tissue injury. Prominent among these toxins are the membrane-active pore-forming cytolysin alpha-toxin (Hla) and the amphipathic α-helical phenol-soluble modulin (PSM) peptides. As deletion of either the hla or psm locus leads to a phenotypically similar virulence defect in skin and soft tissue infection, we sought to determine the relative contribution of each locus to disease pathogenesis. Here we show that production of Hla can be modulated by PSM expression. An S. aureus mutant lacking PSM expression exhibits a transcriptional delay in hla mRNA production and therefore fails to secrete normal levels of Hla at early phases of growth. This leads to attenuation of virulence in vitro and in murine skin and lung models of infection, correlating with reduced recovery of Hla from host tissues. Production of Hla and restoration of staphylococcal virulence can be achieved in the psm mutant by plasmid-driven overexpression of hla. Our study suggests the coordinated action of Hla and PSMs in host tissue during early pathogenesis, confirming a major role for Hla in epithelial injury during S. aureus infection. These findings highlight the possibility that therapeutics targeting PSM production may simultaneously prevent Hla-mediated tissue injury." @default.
• W2148099555 created "2016-06-24" @default.
• W2148099555 creator A5014602771 @default.
• W2148099555 creator A5056173398 @default.
• W2148099555 creator A5064843238 @default.
• W2148099555 creator A5088111187 @default.
• W2148099555 date "2014-08-01" @default.
• W2148099555 modified "2023-10-14" @default.
• W2148099555 title "The <i>psm</i> α Locus Regulates Production of Staphylococcus aureus Alpha-Toxin during Infection" @default.
• W2148099555 cites W1506145586 @default.
• W2148099555 cites W1511569985 @default.
• W2148099555 cites W1533663942 @default.
• W2148099555 cites W1538375169 @default.
• W2148099555 cites W1790927204 @default.
• W2148099555 cites W1908911159 @default.
• W2148099555 cites W1918935787 @default.
• W2148099555 cites W1948355459 @default.
• W2148099555 cites W1972269759 @default.
• W2148099555 cites W1974448472 @default.
• W2148099555 cites W198011542 @default.
• W2148099555 cites W1982285611 @default.
• W2148099555 cites W1984831953 @default.
• W2148099555 cites W2001203391 @default.
• W2148099555 cites W2003086561 @default.
• W2148099555 cites W2008508169 @default.
• W2148099555 cites W2013424910 @default.
• W2148099555 cites W2018545789 @default.
• W2148099555 cites W2020710866 @default.
• W2148099555 cites W2022401822 @default.
• W2148099555 cites W2037816205 @default.
• W2148099555 cites W2038446981 @default.
• W2148099555 cites W2044206614 @default.
• W2148099555 cites W2044750677 @default.
• W2148099555 cites W2044878310 @default.
• W2148099555 cites W2050161704 @default.
• W2148099555 cites W2065737889 @default.
• W2148099555 cites W2066580723 @default.
• W2148099555 cites W2072842693 @default.
• W2148099555 cites W2074295120 @default.
• W2148099555 cites W2075601288 @default.
• W2148099555 cites W2082297445 @default.
• W2148099555 cites W2105536061 @default.
• W2148099555 cites W2106248075 @default.
• W2148099555 cites W2107022818 @default.
• W2148099555 cites W2109977511 @default.
• W2148099555 cites W2110945179 @default.
• W2148099555 cites W2112652622 @default.
• W2148099555 cites W2116607488 @default.
• W2148099555 cites W2121973786 @default.
• W2148099555 cites W2122714192 @default.
• W2148099555 cites W2123720817 @default.
• W2148099555 cites W2123795230 @default.
• W2148099555 cites W2125066910 @default.
• W2148099555 cites W2126467473 @default.
• W2148099555 cites W2127416800 @default.
• W2148099555 cites W2129780251 @default.
• W2148099555 cites W2129965259 @default.
• W2148099555 cites W2134085403 @default.
• W2148099555 cites W2134137910 @default.
• W2148099555 cites W2138666908 @default.
• W2148099555 cites W2139293168 @default.
• W2148099555 cites W2139426406 @default.
• W2148099555 cites W2149548525 @default.
• W2148099555 cites W2150491739 @default.
• W2148099555 cites W2151954592 @default.
• W2148099555 cites W2152862371 @default.
• W2148099555 cites W2155831045 @default.
• W2148099555 cites W2159818846 @default.
• W2148099555 cites W2161672265 @default.
• W2148099555 cites W2163107191 @default.
• W2148099555 cites W2163305262 @default.
• W2148099555 cites W2165016327 @default.
• W2148099555 cites W2168482920 @default.
• W2148099555 cites W2168516112 @default.
• W2148099555 cites W2169029990 @default.
• W2148099555 cites W2171348023 @default.
• W2148099555 cites W2314649741 @default.
• W2148099555 cites W4236842068 @default.
• W2148099555 doi "https://doi.org/10.1128/iai.00089-14" @default.
• W2148099555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4136214" @default.
• W2148099555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24866799" @default.
• W2148099555 hasPublicationYear "2014" @default.
• W2148099555 type Work @default.
• W2148099555 sameAs 2148099555 @default.
• W2148099555 citedByCount "41" @default.
• W2148099555 countsByYear W21480995552015 @default.
• W2148099555 countsByYear W21480995552016 @default.
• W2148099555 countsByYear W21480995552017 @default.
• W2148099555 countsByYear W21480995552018 @default.
• W2148099555 countsByYear W21480995552019 @default.
• W2148099555 countsByYear W21480995552020 @default.
• W2148099555 countsByYear W21480995552021 @default.
• W2148099555 countsByYear W21480995552022 @default.
• W2148099555 countsByYear W21480995552023 @default.
• W2148099555 crossrefType "journal-article" @default.
• W2148099555 hasAuthorship W2148099555A5014602771 @default.
• W2148099555 hasAuthorship W2148099555A5056173398 @default.
• W2148099555 hasAuthorship W2148099555A5064843238 @default.

• next