FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148102009> ?p ?o ?g. }

• W2148102009 endingPage "673" @default.
• W2148102009 startingPage "664" @default.
• W2148102009 abstract "We undertook a detailed cellular and ultrastructural examination of bronchial biopsies from seven allergic asthmatic patients and 10 nonasthmatic control subjects (five atopic and five nonatopic) to determine the nature of the inflammation that occurs during allergen-induced late-phase responses (LPRs). The asthmatic subjects had mild asthma (FEV1 = 94 +/- 9% predicted; mean +/- SEM) and required only intermittent use of beta 2-agonists. Airway mucosal biopsy specimens were obtained on a single occasion from the nonasthmatic controls and on two occasions from the asthmatic subjects, at 24 h after diluent challenge and 24 h after challenge with allergen 3 wk later. The mean maximal decrease in FEV1 during the late response after allergen challenge was 30%, and that after administration of diluent was 4%. In coded plastic sections, subepithelial cells were counted with both light and electron microscopy, and the numbers present were expressed per 0.1 mm2 of tissue. Light microscopy revealed statistically significant increases in the total number of inflammatory cells (P < 0.02) and in activated fibroblasts after allergen challenge (P < 0.05). Electron microscopy showed significant increases after allergen challenge in the total number of eosinophils (P < 0.05) and cells with the ultrastructural features of myofibroblasts. The latter cells constituted 1.5% of cells after administration of diluent, and this increased to 15.5% after allergen challenge (P < 0.05). Mast cells were significantly more abundant in the atopic nonasthmatic controls than in the asthmatic subjects after allergen challenge. The study demonstrates that the profile of inflammatory cells in asthma at 24 h after allergen challenge is distinct from that in stable asthma and in nonasthmatic controls, and that migratory cells with a contractile phenotype appear in greater numbers in the late response. We propose that subjects who repeatedly develop a late response have increased numbers of migrating, contractile cells that may contribute to formation of the increased bronchial smooth-muscle mass observed in fatal asthma." @default.
• W2148102009 created "2016-06-24" @default.
• W2148102009 creator A5007986401 @default.
• W2148102009 creator A5050940925 @default.
• W2148102009 creator A5080629446 @default.
• W2148102009 creator A5081195905 @default.
• W2148102009 creator A5090621880 @default.
• W2148102009 date "1997-06-01" @default.
• W2148102009 modified "2023-10-16" @default.
• W2148102009 title "Myofibroblast involvement in the allergen-induced late response in mild atopic asthma." @default.
• W2148102009 cites W1552424943 @default.
• W2148102009 cites W1981787465 @default.
• W2148102009 cites W1983380531 @default.
• W2148102009 cites W1990730266 @default.
• W2148102009 cites W1991246311 @default.
• W2148102009 cites W1998765849 @default.
• W2148102009 cites W2013105546 @default.
• W2148102009 cites W2018186263 @default.
• W2148102009 cites W2034050426 @default.
• W2148102009 cites W2056367384 @default.
• W2148102009 cites W2063203571 @default.
• W2148102009 cites W2110006329 @default.
• W2148102009 cites W2116313488 @default.
• W2148102009 cites W2143238483 @default.
• W2148102009 cites W2147936230 @default.
• W2148102009 cites W2165981929 @default.
• W2148102009 cites W2171731598 @default.
• W2148102009 cites W2413757075 @default.
• W2148102009 cites W2414730950 @default.
• W2148102009 doi "https://doi.org/10.1165/ajrcmb.16.6.9191468" @default.
• W2148102009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9191468" @default.
• W2148102009 hasPublicationYear "1997" @default.
• W2148102009 type Work @default.
• W2148102009 sameAs 2148102009 @default.
• W2148102009 citedByCount "266" @default.
• W2148102009 countsByYear W21481020092012 @default.
• W2148102009 countsByYear W21481020092013 @default.
• W2148102009 countsByYear W21481020092014 @default.
• W2148102009 countsByYear W21481020092015 @default.
• W2148102009 countsByYear W21481020092016 @default.
• W2148102009 countsByYear W21481020092017 @default.
• W2148102009 countsByYear W21481020092018 @default.
• W2148102009 countsByYear W21481020092019 @default.
• W2148102009 countsByYear W21481020092020 @default.
• W2148102009 countsByYear W21481020092021 @default.
• W2148102009 countsByYear W21481020092022 @default.
• W2148102009 countsByYear W21481020092023 @default.
• W2148102009 crossrefType "journal-article" @default.
• W2148102009 hasAuthorship W2148102009A5007986401 @default.
• W2148102009 hasAuthorship W2148102009A5050940925 @default.
• W2148102009 hasAuthorship W2148102009A5080629446 @default.
• W2148102009 hasAuthorship W2148102009A5081195905 @default.
• W2148102009 hasAuthorship W2148102009A5090621880 @default.
• W2148102009 hasConcept C141105273 @default.
• W2148102009 hasConcept C142724271 @default.
• W2148102009 hasConcept C159654299 @default.
• W2148102009 hasConcept C203014093 @default.
• W2148102009 hasConcept C207480886 @default.
• W2148102009 hasConcept C207865475 @default.
• W2148102009 hasConcept C2776042228 @default.
• W2148102009 hasConcept C2776914184 @default.
• W2148102009 hasConcept C2780510475 @default.
• W2148102009 hasConcept C2780559512 @default.
• W2148102009 hasConcept C71924100 @default.
• W2148102009 hasConceptScore W2148102009C141105273 @default.
• W2148102009 hasConceptScore W2148102009C142724271 @default.
• W2148102009 hasConceptScore W2148102009C159654299 @default.
• W2148102009 hasConceptScore W2148102009C203014093 @default.
• W2148102009 hasConceptScore W2148102009C207480886 @default.
• W2148102009 hasConceptScore W2148102009C207865475 @default.
• W2148102009 hasConceptScore W2148102009C2776042228 @default.
• W2148102009 hasConceptScore W2148102009C2776914184 @default.
• W2148102009 hasConceptScore W2148102009C2780510475 @default.
• W2148102009 hasConceptScore W2148102009C2780559512 @default.
• W2148102009 hasConceptScore W2148102009C71924100 @default.
• W2148102009 hasIssue "6" @default.
• W2148102009 hasLocation W21481020091 @default.
• W2148102009 hasLocation W21481020092 @default.
• W2148102009 hasOpenAccess W2148102009 @default.
• W2148102009 hasPrimaryLocation W21481020091 @default.
• W2148102009 hasRelatedWork W1986190391 @default.
• W2148102009 hasRelatedWork W2013794360 @default.
• W2148102009 hasRelatedWork W2014471812 @default.
• W2148102009 hasRelatedWork W2019808322 @default.
• W2148102009 hasRelatedWork W2037019085 @default.
• W2148102009 hasRelatedWork W2067605016 @default.
• W2148102009 hasRelatedWork W2129149137 @default.
• W2148102009 hasRelatedWork W2145013427 @default.
• W2148102009 hasRelatedWork W2266295269 @default.
• W2148102009 hasRelatedWork W4283364380 @default.
• W2148102009 hasVolume "16" @default.
• W2148102009 isParatext "false" @default.
• W2148102009 isRetracted "false" @default.
• W2148102009 magId "2148102009" @default.
• W2148102009 workType "article" @default.